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Vitamin B6 and immunity

In a nutshell

Vitamin B6 levels are lower in inflammatory conditions and levels are linked with immune response, for example in the critically ill, in autoimmune disorders (such as rheumatoid arthritis) and possibly in HIV infection.

As yet there have been too few clinical trials to tell whether there are specific indications to give B6 supplements in these conditions.

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References
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2. Grimble, RF. Modification of inflammatory aspects of immune function by nutrients. Nutrition Research 1998 Jul;18(7): 12971317.
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5. Kwak, HK. et al. Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet. J Nutr. 2002 Nov;132(11):3308–13.
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14. Chiang, EP. et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med. 2003 Mar;114(4):283–7.
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17. Salhany, JM. et al. Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy. J Biol Chem. 1993 Apr 15;268(11):7643–5.
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24. Ebadi, M. et al. Drug-pyridoxal phosphate interactions. Q Rev Drug Metab Drug Interact. 1982;4(4):289331. Review.
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Arbor Clinical Nutrition Updates
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  • EISSN: 1446-5450
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