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    Giudice, Marco Del and Ellis, Bruce J. 2016. Developmental Psychopathology.

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    Nesse, Randolph M. 2015. The Handbook of Evolutionary Psychology.

    Del Giudice, Marco 2014. An Evolutionary Life History Framework for Psychopathology. Psychological Inquiry, Vol. 25, Issue. 3-4, p. 261.

    Thomas Gualtieri, C. 2014. Autism and Schizophrenia Are Disorders of Evolvability. Open Journal of Medical Psychology, Vol. 03, Issue. 02, p. 161.

    van Dongen, Jenny and Boomsma, Dorret I. 2013. The evolutionary paradox and the missing heritability of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 162, Issue. 2, p. 122.

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    Crespi, Bernard J. 2011. The emergence of human-evolutionary medical genomics. Evolutionary Applications, Vol. 4, Issue. 2, p. 292.

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    Nesse, Randolph M. 2006. Darwinian medicine and mental disorders. International Congress Series, Vol. 1296, p. 83.


Cliff-edged fitness functions and the persistence of schizophrenia

  • Randolph M. Nesse (a1)
  • DOI:
  • Published online: 01 December 2004

Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a “fitness cliff” where the system fails catastrophically in some individuals.

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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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