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Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

  • Neal R. Swerdlow (a1) and George F. Koob (a2)

Considerable evidence from preclinical and clinical investigations implicates disturbances of brain dopamine (DA) function in the pathophysiology of several psychiatric and neurologic disorders. We describe a neural model that may help organize theseindependent experimental observations. Cortical regions classically associated with the limbic system interact with infracortical structures, including the nucleus accumbens, ventral pallidum, and dorsomedial nucleus of the thalamus. In our model, overactivity in forebrain DA systems results in the loss of lateral inhibitory interactions in the nucleus accumbens, causing disinhibition of pallidothalamic efferents; this in turn causes rapid changes and a loss of focused corticothalamic activity in cortical regions controlling cognitive and emotional processes. These effects might be manifested clinically by some symptoms of psychoses. Underactivity of forebrain DA results in excess lateral inhibition in the nucleus accumbens, causing tonic inhibition of pallidothalamic efferents; this perpetuates tonic corticothalamic activity and prevents the initiation of new activity in other critical cortical regions. These effects might be manifested clinically by some symptoms of depression. This model parallels existing explanations for the etiology of several movement disorders, and may lead to testable inferences regarding the neural substrates of specific psychopathologies.

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L. E. Adler , G. Rose & R. Freedman (1986) Neurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine, and haloperidol. Biological Psychiatry 21:787–98. [rNRS]

R. Alarcon & M. De Carney (1969) Severe depressive mood changes following slow release intramuscular fluphenazine injection. British Medical Journal 3:564. [arNRS]

M. Albus , M. Ackenheil , U. Munch & D. Naber (1984) Ceruletide: A new drug for the treatment of schizophrenic patiens? Archives of General Psychiatry 41:528. [rNRS]

G. Alfredsson , C. Harnryd & F. A. Wiesel (1985) Effects of sulpiride and chlorpromazine on autistic and positive symptoms in schizophrenic patients: Relationship to drug concentrations. Psychopharmacology 85:813. [PS]

American Medical Association (1985) Consensus conference: Electroconvulsive therapy. Journal of the American Medical Association 254:2103–8. [aNRS]

A. Amsel (1962) Frustrative nonreward in partial reinforcement and discrimination learning: Some recent history and a theoretical extension. Psychological Review 69:306–28. [JAG]

J. D. Amsterdam , A. Winokur , I. Lucki , S. Caroff , P. Snyder & K. Rickels (1983) A neuroendocrine test battery in bipolar patients and healthy subjects. Archives ofCeneral Psychiatry 40:515–22. [aNRS]

N. C. Andreasen , H. A. Nasrallah , V. Dunn , S. C. Olson , W. M. Grove , J. A. Ehrhardt , J. A. Coffman & J. H. W. Crossett (1986) Structural abnormalities in the frontal system in schizophrenia. Archives of General Psychiatry 43:136–47. [AEK]

N. C. Andreasen & S. Olsen (1982) Negative and positive schizophrenia: Definition and validation. Archives of General Psychiatry 39: 789–94. [PS]

H. Anisman , J. Irwin & L. S. Sklar (1979) Deficits of escape performance following catecholamine depletion: Implications for behavioral deficits induced by uncontrollable stress: Psychopharmacology 64:163–70. [aNRS]

H. Anisman , G. Remington & L. S. Sklar (1979) Effects of inescapable shock on subsequent escape performance: Catecholaminergic and cholinergic mediation of response initiation and maintenance. Psychopharmacology 61:107–24. [aNRS]

H. Anisman , A. Suissa & L. S. Sklar (1980) Escape deficits induced by uncontrollable stress: Antagonism by dopamine and noradrenaline agonists. Behavioral and Neural Biology 28:3447. [aNRS]

M. Arluison , Y. Agid & F. Javoy (1978) Dopaminergic nerve endings in the neostriatum of the rat. I. Identification by intracerebral injections of 5 hydroxydopamine. Neurosdence 3:657–73. [JHF]

R. J. Baldessarini & D. Tarsy (1980) Dopamine and the pathophysiology of dyskinesias induced by antipsychotic drugs. Annual Review of Neurosdence 3:2341. [aNRS]

B. Bank , J. Gurd & D. L. Chute (1986) Decreased phosphorylation of synaptic glycoproteins following hippocampal kindling. Brain Research 399:390–94. [DLC]

L. R. Baxter , M. E. Phelps , J. C. Maziotta , J. C. Schwartz , R. H. Gerner , G. E. Selin & R. M. Sumida (1985) Cerebral metabolic rates for glucose in mood disorders. Archives ofCeneral Psychiatry 42:441–47. [arNRS]

R. M. Beckstead (1979) An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. Journal of Comparative Neurology 184:4362. [GEJ, AEK]

A. Beigel & D. L. Murphy (1971) Unipolar and bipolar affective illness: Differences in clinical characteristics accompanying depression. Archives of General Psychiatry 24:215–20. [AEK]

J. P. Bennett , S. J. Enna , D. B. Bylund , J. C. Gillin , R. J. Wyatt & S. H. Snyder (1979) Neurotransmitter receptors in frontal cortex of schizophrenics. Archives of General Psychiatry 36:927–34. [aNRS]

G. Bernardi , E. Cherubini , G. Marciani , N. Mercuri & P. Stanzione (1982) Responses of intracellularly recorded cortical neurons to the iontophoretic application of dopamine. Brain Research 245:267–74. [rNRS]

E. D. Bird , E. G. Spokes & L. L. Iversen (1979) Increased dopamine concentrations in limbic areas of brain from patients dying with schizophrenia. Brain 102:347–60. [aNRS, PMB]

B. Bogerts , E. Meertz & R. Schonfeldt-Bausch (1985) Basal ganglia and limbic system pathology in schizophrenia. Archives of General Psychiatry 42:784–91. [JRS]

F. Borsini , L. Pulvirenti & R. Saminin (1985) Evidence of dopamine involvement in the effect of repeated treatment with various antidepressants in the behavioural “despair” test in rats. European Journal of Pharmacology 110:253–56. [PS]

M. B. Bowers Jr, (1974) Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry 31:5054. [aNRS]

M. B. Bowers Jr, & F. J. Hoffman Jr, (1986) Homovanillic acid in caudate and prefrontal cortex following acute and chronic neuroleptic administration. Psychopharmacology 88:6365. [GEJ]

D. L. Braff , C. Stone , E. Callaway , M. Geyer , I. Click & L. Bali (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339–43. [arNRS]

S. Bridge , M. J. Christie , & P. M. Beart (1986) No change in neostriatal D-2 dopamine receptors after NMDA lesions of rat prefrontal cortex. Pharmacology, Biochemistry and Behaviour 24:1829–32. [PMB]

T. P. Bridge , J. E. Kleinman , B. J. Soldo & F. Karoum (1987) Central catecholamines, cognitive impairment and affective state in elderly schizophrenics and controls. Biological Psychiatry 22:139–47. [rNRS]

M. S. Buchsbaum & R. O. Rieder (1979) Biologic heterogeneity and psychiatric research. Archives of General Psychiatry 36:1163–69. [AW]

B. S. Bunney & A. A. Grace (1978) Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 23:1715–28. [AAG]

W. E. Bunney Jr, & M. Davis (1965) Norepinephrine in depressive reactions. Archives of General Psychiatry 13:483–94. [aNRS]

R. Cancro (1979) Genetic evidence for the existence of subgroups of the schizophrenic syndrome. Schizophrenic Bulletin 5:453–59. [AW]

P. Carnoy , S. Ravard , B. Wemerman , P. Soubrie & P. Simon (1986) Behavioral deficits induced by low doses of apomorphine in rats: Evidence for a motivational and cognitive dysfunction which discriminates among neuroleptic drugs. Pharmacology Biochemistry and Behavior 25:503–9. [PS]

G. D. Carr & N. M. White (1983) Conditioned place preference from intraaccumbens but not intra-caudate amphetamine injections. Life Sciences 33:2551–57. [AEK]

G. D. Carr & N. M. White (1986) Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study. Psychopharmacology 89:340–46. [AEK]

R. Cash , T. Dennis , R. L'Heureux , R. Raisman , F. Javoy-Agid & B. Scatton (1987) Parkinson's disease and dementia: Norepinephrine and dopamine in locus ceruleus. Neurology 37:4246. [rNRS]

D. S. Charney , D. B. Menkes & G. R. Heninger (1981) Receptor sensitivity and the mechanism of action of antidepressant treatment. Archives of General Psychiatry 38:1160–80. [AEK]

L. A. Chiodo & T. W. Berger (1986) Interactions between dopamine and amino acid induced excitation and inhibition in the striatum. Brain Research 375:198203. [AAG]

M. J. Christie , S. Bridge , L. B. James & P. M. Beart (1985) Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area. Brain Research 333:169–72. [PMB]

M. J. Christie , L. B. James & P. M. Beart (1985) An excitant amino acid projection from the medial prefrontal cortex to the anterior part of the nucleus accumbens in the rat. Journal of Neurochemistry 45:477–82. [PMB]

M. J. Christie , P. J. Rowe & P. M. Beart (1986) Effect of excitotoxin lesions in the medial prefrontal cortex on cortical and subcortical catecholamine turnover in the rat. Journal of Neurochemistry 47:1593–97. [PMB]

H. C. Chui , J. A. Mortimer , U. Slager , C. Zarow , W. Bondareff & D. D. Webster (1986) Pathological correlates of dementia in Parkinson's disease. Archives of Neurology 43:991–95. [AEK]

P. Clayton , F. N. Pitts Jr, & G. Winokur (1965) Affective disorder: IV. Mania. Comparative Psychiatry 6:313–22. [AEK]

D. H. Cohen (1986) Coming of age in neuroscience. Trends in Neurosciences 9:450–52. [MLM]

A. R. Cools (1985a) Morphine and specific changes in the sensitivity of noradrenergic receptors within the “limbic” part of the feline caudate nucleus: A behavioural study. Brain Research Bulletin 14:239–50. [PMB]

A. R. Cools (1985b) Brain and behavior: Hierarchy of feedback systems and control of input. In: Perspectives in Ethology 6 (Mechanisms), ed. P. P. G. Bateson & P. H. Klopfer . Plenum. [ARC]

A. R. Cools , R. Jaspers , M. Schwarz , K. H. Sontag , M. Vrijmoed-de Vries & J. van den Bercken (1984) Basal ganglia and switching motor programs. In: The basal ganglia, ed. J. S. McKenzie , R. E. Kemm & L. N. Wilcock . Plenum. [ARC]

A. R. Cools , J. van den Berken , M. Horstink , K. van Spaendonok & H. Berger (1984) Cognitive and motor shifting aptitude disorder in Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry 47:443–53. [aNRS]

A. Coppen (1967) The biochemistry of affective disorders. British Journal of Psychiatry 113:1237–64. [aNRS]

B. Costall , A. M. Domeney & R. J. Naylor (1982) Behavioral and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat. Neuropharmacology 21:327–35. [aNRS]

I. Creese , D. R. Burt & S. H. Snyder (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192:481–82. [aNRS, CEJ]

I. Creese & S. D. Iversen (1975) The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Research 83:419–36. [aNRS]

I. Creese & D. R. Sibley (1981) Receptor adaptations to centrally acting drugs. Annual Review of Pharmacology and Toxicology 21:357–89. [aNRS]

A. J. Cross , T. J. Crow , W. S. Killpack , A. Longden , F. Owen & G. J. Riley (1978) The activity of brain dopamine-beta-hydroxylase and catechol-O-methyl-transferase in schizophrenics and controls. Psychopharmacology(Berlin) 59:117–21. [aNRS]

A. J. Cross , T. J. Crow & F. Owen (1981) 3-H-flupenthixol binding in postmortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors. Psychopharmacology 74:122–24. [arNRS]

T. J. Crow (1980) Molecular pathology of schizophrenia: More than one disease process? British Medical Journal 280:6668. [aNRS]

T. J. Crow (1982) Two syndromes in schizophrenia? Trends in Neurosciences 5:351–54. [AP]

J. C. Csernancky , C. A. Csernansky , K. A. Bonnet & L. E. Hollister (1985) Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures. Biological Psychiatry 20:723–33. [aNRS]

W. Danielezyk (1983) Various mental behavioral disorders in Parkinson's disease, primary degenerative senile dementia and multiple infarction dementia. Journal of Neural Transmission 56:161–76. [rNRS]

M. Davis & G. K. Aghajanian (1976) Effects of apomorphine and haloperidol on the acoustic startle response in rats. Psychopharmacology 47:217223. [aNRS]

M. Davis & J. Kehne (1985) Cocaine-excitatory effects of sensorimotor reactivity measured with acoustic startle. Psychopharmacology 86:3136. [aNRS]

J. F. DeFrance , R. W. Sikes & Z. Gottesfeld (1983) Regional distribution of catecholamines in nucleus accumbens of the rabbit. Journal of Neuwchcmistry 40:291–93. [rNRS, PMB]

R. A. Depue & S. M. Monroe (1978) The unipolar-bipolar distinction in the depressive disorders. Psychological Bulletin 85:1001–29. [AEK]

T. Detre , J. Himmelhoch , M. Swartzburg , C. M. Anderson , R. Byck & D. J. Kupfer (1972) Hypersomnia and manic-depressive disease. American Journal of Psychiatry 128:1303–5. [AEK]

H. deWit & R. A. Wise (1978) Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine and phenoxybenzamine. Canadian Journal of Psychology 31:195203. [aNRS]

I. Divac , A. Bjorklund , O. Lindvall & R. E. Passingham (1978) Converging projections from the medio-dorsal nucleus and mesencephalic dopaminergic neurons to the neocortex in three species. Journal of Comparative Neurology 180:5972. [GE], JPT]

N. S. Downs , K. T. Britton , D. M. Gibbs , G. F. Koob & N. R. Swerdlow (1986) Supersensitive endocrine response to physostigmine in dopamine depleted rats: A model of depression. Biological Psychiatry 21:773. [arNRS]

A. Dray & N. R. Oakley (1978) Projections from nucleus accumbens to globus pallidus and substantia nigra in the rat. Experientia 34:6870 [rNRS]

C. L. Ehlers , J. H. Indik , G. F. Koob & F. E. Bloom (1983) The effect of a single and repeated electroconvulsive shock (ECS) on locomotor activity in rats. Progress in Neuropsychopharmacology and Biological Psychiatry 7:217–22. [aNRS]

C. L. Ehlers & G. F. Koob (1985) Locomotor behavior following kindling in three different brain sites. Brain Research 326:7179. [aNRs]

P. C. Emson & G. F. Koob (1978) The origin and distribution of dopamine containing afferents to the rat frontal cortex. Brain Research 142:249–67. [aNRS]

K. Endo , T. Araki & N. Yagi (1973) The distribution and pattern of axon branching of pyramidal tract cells. Brain Research 57:484–91. [aNRS]

J. H. Fallon , R. Hicks & S. E. Loughlin (1983) The origin of cholecystokinin terminals in the basal forebrain of the rat: Evidence from immunofluorescence and retrograde tracing. Neuroscience Letters 37:2935. [JHF]

T. Farkas A. P. Wolf , J. Jaeger , J. D. Brodie , D. R. Christman & J. S. Fowler (1984) Regional brain glucose metabolism in chronic schizophrenia. Archives of General Psychiatry 41:293300. [AW]

I. J. Farley , K. S. Price , E. McCullough , J. H. N. Deck , W. Hordynski & O. Hornykiewicz (1978) Norepinephrine in chronic paranoid schizophrenia: Above-normal levels in limbic forebrain. Science 200:456–58. [PMB]

P. Feltz & D. Albe-Fessard (1972) A study of an ascending nigrocaudate pathway. Electroencephalography and Clinical Neurophysiology-EEG Journal 33:179–93. [JHF]

H. C. Fibiger , D. A. Carter & A. G. Phillips (1976) Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: Evidence for mediation by motor deficits rather than by reduced reward. Psychopharmacology 47:2127. [aNRW]

H. C. Fibiger & K. G. Lloyd (1984) The neurobiological substrates of tardive dyskinesia: The GABA hypothesis. Trends in Neuroscience 7:462–64. [HCF]

K. A. Flowers & C. Robertson (1985) The effect of Parkinson's disease on the ability to maintain a mental set. Journal of Neurology, Neurosurgery and Psychiatry 48:517–29. [aNRS]

F. Fonnum , J. Storm-Mathisen & I. Divac (1981) Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain. Neuroscience 6:863–73. [aNRS]

G. Franzen & D. H. Ingvar (1975) Abnormal distribution of cerebral activity in chronic schizophrenia. Journal of Psychiatric Research 12:199214. [aNRS]

A. J. Friedhoff (1986) A dopamine dependent restitutive system for the maintenance of mental normalcy. Annals of the New York Academy of Sciences 463:4752. [rNRS]

A. J. Friedhoff & E. Van Winkle (1962) Isolation and characterization of a compound from the urine of schizophrenics. Nature 194:897–99. [aNRS]

D. Galey , T. Durkin , G. Sitakis , E. Kempf & R. Jaffard (1985) Facilitation of spontaneous and learned spatial behaviours following 6- hydroxydopamine lesions of the lateral septum: A cholinergic hypothesis. Brain Research 340:171–74. [JAG]

D. W. Gallagher , A. Pert & W. E. Bunney (1978) Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium. Nature 273:309–12. [aNRS]

M. Gelissen & A. Cools (1986) The interrelationship between superior colliculus and substantia nigra pars reticulata in programming movements of cats. Behavioural Brain Research 21:8593. [ARC]

C. R. Gerfen (1984) The neostriatal mosaic: Cornpartmentalization of corticostriatal input and striatonigral output systems. Nature 311:461–64. [aNRS]

A. Ginton , G. Urea & R. E. Lubow (1975) The effects of preexposure to a non-attended stimulus on subsequent learning: Latent inhibition in adults. Bulletin of the Psychonomic Society 5:58. [JAG]

J. Glowinski , J. P. Tassin & A. M. Thierry (1984) The mesocorticoprefrontal dopaminergic neurons. Trends in Neuroscience 7:415–18. [GEJ, JPT]

C. J. Golden , B. Graber , J. Coffman , R. A. Berg , D. B. Newlin & S. Bloch (1981) Structural brain deficits in schizophrenia. Archives of General Psychiatry. 38:1014–17. [AEK]

P. S. Goldman & W. J. H. Nauta (1977) An intricately patterned prefrontalcaudate projection in the rhesus monkey. Journal of Comparative Neurology 171:369–86. [AEK]

A. A. Grace & B. S. Bunney (1985) Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 333:271–84. [AAG]

A. R. Green , D. J. Heal & D. G. Grahame-Smith (1977) Further observations on the effect of repeated electroconvulsive shock on the behavioral responses of rats produced by increase in the functional activity of brain 5-hydroxytryptamine and dopamine. Psychopharmacology 52:195200. [aNRS]

F. Gregoire , H. Brauman , R. Debuck & J. Corvilain (1977) Hormone release in depressed patients, before and after recovery. Psychoneuroendocrinology 2:303–11. [aNRS]

H. J. Groenewegen & F. T. Russchen (1984) Organization of the efferent projections of the immunohistochemical study in the cat. Journal of Comparative Neurology 223:347–67. [GFA]

E. Grof , G. M. Brown & P. Grof (1983) Neuroendocrine strategies in affective disorders. Progress in Seuropsychopharmacology and Biological Psychology 7:557–82. [aNRS]

P. M. Groves (1983) A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement. Brain Research Reviews 5:109–32. [aNRS, JHF, ELG, AAG]

J. H. Gruzelier & P. H. Venables (1972) Skin conductance orienting activity in a heterogeneous sample of schizophrenics. Journal of Nervous and Mental Disease 155:277–87. [rNRS]

S. N. Haber & S. J. Watson (1985) The comparative distribution of enkephalin, dynorphin and substance P in the human globus pallidus and basal forebrain Neurosdence 14:1011–24. [aNRS]

A. Halaris , K. Belendiuk & D. Freedom (1975) Antidepressant drugs affect brain dopamine. Biochemical Pharmacology 24:1896–98. [arNRS]

M. D. Hall , P. Jenner , E. Kelly & C. D. Marsden (1983) Differential anatomical location of [3H]-N,n-propylnorapomorphine and [3H] spiperone binding sites in the striatum and substantia nigra of the rat. British Journal of Pharmacology 79:599610. [PMB]

R. G. Heath (1962) Common characteristics of epilepsy and schizophrenia: Clinical observation and depth electrode studies. American Journal of Psychiatry 118:1013–26. [aNRS]

L. Heimer , R. D. Switzer & G. W. Van Hoesen (1982) Ventral striatum and ventral pallidum: Components of the motor system?. Trends in Neurosdence 5:8387. [aNRS]

J. P. Herman , D. Guilloneau , R. Dantzer , B. Scatton , L. Semerdjian-Rouquier & M. Le Moal (1982) Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshock on dopamine turnover in cortical and limbic areas of the rat. Life Sdences 30:2207–14. [GEJ]

P. L. Herrling & C. D. Hull (1984) Iontophoretically applied dopamine depolarizes and hyperpolarizes the membrane of cat caudate neurons Brain Research 192:441–62. [rNRS]

S. M. Hersh & E. L. White (1981) Thalamocortical synapses with corticothalamic projection neurons in mouse sml cortex: Electron microscopic demonstration of a monosynaptic feedback loop. Neurosdence Letters 24:207–10. [aNRS]

D. Herve , J. M. Studler , G. Blanc , J. Glowinski , & J. Tassin (1986) Partial protection by desmethylimipramine of the mesocortical dopamine neurones from the neurotoxic effect of 6-hydroxydopamine injected in ventral mesencephalic tegmentum. The role of noradrenergic innervation. Brain Research 383:4753. [rNRS]

B. G. Hoebel , A. P. Monaco , L. Hernandez , E. F. Aulisi , B. G. Stanley & L. Lenard (1983) Self-injection of amphetamine directly into the brain. Psychopharmacology 81:158–63. [AEK]

T. Hokfelt , B. J. Eferitt , E. Theodorsson-Norheim & M. Goldstein (1984) Occurrence of neurotensin-like immunoreactivity in subpopulations of hypothalamic, mesencephalic, and medullary catecholamine neurons. Journal of Comparative Neurology 222:543–59. [PWK]

T. Hokfelt , L. Skirboll , J. Rehfeld , M. Goldstein , M. Markey & O. Dann (1980) A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunocytochemistry combined with retrograde tracing. Neurosdence 5:20932124. [JHF]

D. W. Hommer , D. Pickar , A. Roy , P. Ninan , J. Boronow & S. Paul (1984) The effects of ceruletide in schizophrenia. Archives of General Psychiatry 41:617–19. [rNRS]

O. Hornykiewicz (1982) Brain catecholamines in schizophrenia - a good case for noradrenaline. Nature 299:484–86. [PMB]

B. L. Jacobs , M. E. Trulson & W. C. Stem (1977) Behavioral effects of LSD in the cat: Proposal of an animal behavior model for studying the actions of hallucinogenic drugs. Brain Research 132:301–14. [aNRS]

R. S. Jaeckle & H. A. Nasrallah (1985) Major depression and carbon monoxide-induced parkinsonism: Diagnosis, computerized axial tomography, and response to L-dopa. Journal of Nervous and Mental Disorders 173:503–8. [aNRS]

R. Jaspers , M. Schwarz , K.-H. Sontag & A. Cools (1984) Caudate nucleus and programming behaviour in cats: Role of dopamine in switching motor patterns. Behavioural Brain Research 14:1728. [ARC]

F. Javoy-Agid & Y. Agid (1980) Is the mesocortical dopaminergic system involved in Parkinson's disease? Neurology 30:1326–30. [aNRS]

D. L. Jones & G. J. Mogenson (1980a) Nucleus accumbens to globus pallidus GABA projection: Electrophysiological and iontophoretic investigations. Brain Research 188:93105. [arNRS]

E. G. Jones & T. P. S. Powell (1970) An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 93:793820. [aNRS][

E. M. Joyce , G. F. Koob , R. Strecker , S. D. Iversen & F. E. Bloom (1981) The behavioral effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. Brain Research 221:359–70. [PWK]

P. W. Kalivas (1985) Interactions between neuropeptides and dopamine neurons in the ventromedial mesencephalon. Neuroscience and Biobehavioral Reviews 9:573–87. [PWK]

J. H. Kehne & C. A. Sorenson (1978) The effects of pimozide and phenoxybenzamine pretreatment on amphetamine and apomorphine potentiation of the acoustic startle response in rats. Psychopharmacology 58:137–44. [aNRS]

A. E. Kelley & V. B. Domesick (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde- and retrograde-horseradish peroxidase study. Neuroscience 7:2321–35. [aNRS, JAG]

A. E. Kelley , V. B. Domesick & W. J. H. Nauta (1982) The amygdalostriatal projection in the rat – an anatomical study by anterograde and retrograde tracing methods. Neuroscience 7:615–30. [aNRS, AEK]

A. E. Kelley & L. Stinus (1985) Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-dopa. Behavioral Neuroscience 99:531–45. [arNRS, AEK]

A. E. Kelley , L. Stinus & S. D. Iversen (1980) Interactions between D-alamet-enkephalin, A10 dopaminergic neurones, and spontaneous behavior in the rat. Behavioral Brain Research 1:324. [aNRS]

P. H. Kelly & S. D. Iversen (1976) Selective 6-OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats. European Journal of Pharmacology 40:4556. [aNRS]

P. H. Kelly P. W. Seviour , & S. P. Iversen (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens, septi, and corpus striatum. Brain Research 94:507–22. [aNRS, AEK]

I.C. Kilpatrick , C. Collingridge & M. Starr (1982) Evidence for the participation of nigrotectal gammaaminobutyrate containing neurons in striatal and nigral-derived circling in the rat. Neuroscience 7:207–22. [AAC]

J. S. Kim , R. Hassler , P. Haug & K. S. Paik (1977) Effect of frontal cortex ablation on striatal glutamic acid level in rat. Brain Research 132:370–74. [aNRS]

H. Kita , T. Kita & S. T. Kitai (1985) Regenerative potentials in rat neostriatal neurons in an in vitro slice preparation. Experimental Brain Research 60:6370. [AAG]

S. T. Kitai , M. Iuginiori & J. D. Kocsis (1976) Excitatory nature of dopamine in the nigro-caudate pathway. Experimental Brain Research 24:351–63. [JHF]

B. Kolb & I. Q. Whishaw (1983) Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurologic patients. Journal of Nervous and Mental Disease 171:435–43. [BK]

G. F. Koob , G. J. Balcom & J. L. Meyerhoff (1976) Increases in intracranial self-stimulation in the posterior hypothalamus following unilateral lesions in the locus coeruleus. Brain Research 101:554–60. [rNRS]

G. F. Koob , S. J. Riley , S. C. Smith & T. W. Robbins (1978) Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity and amphetamine anorexia in the rat. Journal of Comparative and Physiological Psychology 92:917–27. [AEK]

C. Kornetsky (1976) Hyporesponsivity of chronic schizophrenic patients to dextroamphetamine. Archives of General Psychiatry 33:1425–28. [aNRS]

M. R. Kozlowski , K. A. Neve , J. E. Grishman & J. F. Marshall (1983) Chronic lithium administration alters behavioral recovery from nigrostriatal injury: Effects on neostriatal (3H) spiroperidol binding sites. Brain Research 267:301–11. [aNRS]

S. Lavielle , J. P. Tassin , A. M. Thierry , G. Blanc , D. Hervé , C. Barthélémy & J. Glowinski (1979) Blockade by benzodiazepines of the selective high increase in DA turnover induced by stress in mesocortical DA neurons of the rat. Brain Research 168:585–94. [JPT]

C. Le Dourarin , A. Oblin , D. Fage & B. Scatton (1983) Influence of lithium on biochemical manifestations of striatal dopamine target cell supersensitivity induced by prolonged haloperidol treatment. European Journal of Pharmacology 93:5562. [aNRS]

T. Lee , P. Seeman , W. W. Tourellotte , I. J. Farley & O. Hornykeiwicz (1978) Binding of 3-H-neuroleptics and 3-H-apomorphine in schizophrenic brains. Nature 274:897900. [arNRS]

N. J. Leith & R. J. Barrett (1980) Effects of chronic amphetamine or reserpine on self-stimulation responding: Animal model of depression? Psychopharmacology 72:915. [aNRS]

M. Le Moal , B. Cardo & L. Stinus (1969) Influence of ventral mesencephalic lesions on various spontaneous and conditional behaviours in the rat. Physiology b Behaviour 4:567–74. [JPT]

C. M. Leonard (1969) The prefrontal cortex of the rat. Brain Research 12:321–43. [GEJ]

S. Levin (1984b) Frontal lobe dysfunction in schizophrenia II: Impairments of psychological brain functions. Journal of Psychiatric Research 18:5772. [AEK]

R. Llinas & Y. Yarom (1981) Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro. Journal of Physiology (London) 315:569–84. [AAG]

A. W. Loranger (1981) Genetic independence of manic-depression and schizophrenia. Acta Psychiatrica Scandinavica 63:444–52. [AEK]

A. Louilot , H. Simon , K. Taghzouti & M. Le Moal (1985) Modulation of dopaminergic activity in the nucleus accumbens following facilitation or blockade of the dopaminergic transmission in the amygdala: A study by in vivo differential pulse voltammetry. Brain Research 346:141–45. [JPT]

R. E. Lubow (1973) Latent inhibition. Psychological Bulletin 79:398407. [JAG]

A. V. P. Mackay (1982) Increased brain dopamine and dopamine receptors in schizophrenia. Archives of General Psychiatry 39:991–97. [arNRS]

S. F. Maier & M. E. P. Seligman (1976) Learned helplessness: Theory and evidence. Journal of Experimental Psychology: General 105:346. [aNRS]

L. Major , D. L. Murphy & S. Lipper (1979) Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine and serotonin in human cerebrospinal fluid. Journal of Neurochemistry 32:229–31. [aNRS]

C. D. Marsden (1980) The enigma of the basal ganglia and movement. Trends in Neurosciences 3:284–87. [GFA]

M. T. Martin-Iverson , J. F. Leclere & H. C. Fibiger (1983) Cholinergicdopaminergic interactions and the mechanisms of action of antidepressants. European Journal of Pharmacology 94:193201. [aNRS]

J. A. Mattes , W. Horn , J. M. Rochford & M. Orlosky (1985) Ceruletide for schizophrenia: A double-blind study. Biological Psychiatry 20:533–38. [rNRS]

R. Mayeux , Y. Stern , J. Rosen & J. Leventhal (1981) Depression, intellectual impairment, and Parkinson's disease. Neurology 31:645–50. [aNRS]

M. S. McCabe , R. C. Fowler , R. J. Cadoret & G. Winokur (1972) Symptom differences in schizophrenia with good and poor prognosis. American Journal of Psychiatry 128:1239–43. [AEK]

P. L. McGeer & E. G. McGeer (1980) Chemistry of mood and emotion. Annual Review of Psychology 31:273307 [GFA]

D. C. Mclntyre & R. J. Racine (1986) Kindling mechanisms: Current progress on an experimental epilepsy model. Progress in Neurobiology 27:112. [ELG]

I. M. Mclntyre , C. Kuhn , S. Demitriou , F. R. Fucek & M. Stanley (1983) Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine. Psychopharmacology 81:150–54. [aNRS]

H. McLennan & D. H. York (1967) The action of dopamine on neurons of the caudate nucleus. Journal of Physiology-London 189:393402. [rNRS]

H. Y. Meltzer (1979) Biology of schizophrenia subtypes: A review and proposal for method of study. Schizophrenia Bulletin 5:460–78. [AW]

M. M. Mesulam , E. J. Mufson , A. I. Levey & B. H. Wainer (1983) Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basatis (substantia innominata), and hypothalamus in the rhesus monkey. Journal of Comparative Neurology 214:170–97. [aNRS]

R. H. S. Mindham (1970) Psychiatric symptoms in parkinsonism. Journal of Neurological Psychiatry 33:188–91. [rNRS]

G. J. Mogenson , D. L. Jones & C. Y. Yim (1980) From motivation to action: Functional interface between the limbic system and the motor system. Progress in Neurobiology 14:6997. [PMB]

G. J. Mogenson & M. A. Nielson (1982) Evidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity. Brai Research Bulletin 11:309–14. [rNRS]

J. M. Morihisa & G. B. McAnulty (1985) Structure and function: Brain electrical activity mapping and computerized tomography of schizophrenia. Biological Psychiatry 20:319. [GEJ]

J. H. Morrison & P. J. Magistretti (1983) Monoamines and peptides in cerebral cortex: Contrasting principles of cortical organization. Trends in Neuroscience 6:146–51. [aNRS]

O. H. Mowrer (1960) Learning theory and behavior. Wiley. [JAG]

K. T. Mueser & M. W. Dysken (1983) Narcotic antagonists in schizophrenia: A methodological review. Schizophrenia Bulletin 9:213–25. [PWK]

H. F. Müller (1985) Prefrontal cortex dysfunction as a common factor in psychosis. Acta Psychiatrica Scandinavica 71:431–40. [aNRS]

W. J. H. Nauta (1971) The problem of the frontal lobe: A reinterpretation. Journal of Psychiatric Research 8:167–87. [arNRS]

W. J. H. Nauta , G. P. Smith , V. B. Domesick & R. L. M. Faull (1978) Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience 3:385401. [aNRS]

C. B. Nemeroff , E. Widerlov , G. Bissette , H. Walleus , I. Karlsson , K. Eklund , C. D. Kilts , P. T. Loosen & W. Vale (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:1342–43. [aNRS]

B. Nurse , V. A. Russell & J. J. F. Taljaard (1985) Effect of chronic desipramine treatment on adrenoceptor modulation of [3H] dopamine release from rat nucleus aecumbens slices. Brain Research 334:235–42. [arNRS, PMB]

R. G. E. Oberg & I. Divac (1981) The basal ganglia and the control of movement. Trends in Neurosciences 4:122–24. [GFA]

D. N. Pandya & H. G. J. M. Kuypers (1969) Cortico-cortical connections in the rhesus monkey. Brain Research 13:1336. [aNRS]

M. R. Park , J. W. Lighthall & S. T. Kitai (1980) Recurrent inhibition in the rat neostriatum. Brain Research 194:359–69. [AAG]

H. I. Patrick & D. M. Levy (1922) Parkinson's disease: A clinical study of 146 cases. Archives of Neurological Psychiatry (Chicago) 7:711–20. [rNRS]

J. B. Penney & A. B. Young (1981) GABA as the pallidothalamic neurotransmitter: Implications for basal ganglia function. Brain Research 207:195–99. [aNRS]

J. B. Penney & A. B. Young (1983) Speculations on the functional anatomy of basal ganglia disorders. Annual Review of Neuroscience 6:7394. [arNRS, PmB]

J. B. Penney & A. B. Young (1986) Striatal inhomogeneities and basal ganglia function. Movement Disorders 1:315. [ARC]

T. L. Perry , S. Hansen & M. Kloster (1973) Huntington's chorea: Deficiency of aminobutyric acid in brain. New England Journal of Medicine 288:337–42. [JRS]

A. Pert , J. E. Rosenblatt , C. Sivit , C. B. Pert & W. E. Bunney (1978) Long term treatment with lithium prevents the development of dopamine receptor supersensitivity. Science 201:171–73. [aNRS]

A. Pert & C. Sivit (1977) Neuroanatomical focus for morphine and enkephalin-induced hypermotility. Nature 265:645–47. [PWK]

E. Peselow , B. Angrist , A. Sudilovsky , J. Corwin , J. Siekierski , F. Trent & J. Rotrosen (1987) Double blind controlled trials of cholecystokinin octapeptide in neuroleptic-refractory schizophrenia. Psychopharmacology 91:8084. [rNRS]

H. O. Petit , A. Ettenberg , F. E. Bloom & G. F. Koob (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology 84:167–73. [AEK]

A. G. Phillips (1984) Brain reward circuitry: A case for separate systems. Brain Research Bulletin 12:195201. [AP]

K. J. Pittman , A. Jakubovic & H. C. Ribiger (1984) The effects of chronic lithium on behavioral and biochemical indices of dopamine receptor supersensitivity in the rat. Psychopharmacology 82:371–77. [aNRS]

H. G. Pope Jr, & J. F. Lipinski (1978) Diagnosis in schizophrenia and manic-depressive illness. Archives of General Psychiatry 35:811–28. [aNRS, AEK]

R. D. Porsolt , G. Anton , N. Blavet & M. Jalfre (1978) Behavioural despair in rats: A new model sensitive to antidepressant treatments. European Journal of Pharmacology 47:379–91. [aNRS]

R. D. Porsolt , A. Bertin , N. Blavet , M. Deniel & M. Jalfre (1979) Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity. European Journal of Pharmacology 57:201–10. [aNRS]

R. D. Porsolt , M. Le Pichon & M. Jalfre (1977) Depression: A new animal model sensitive to antidepressant treatments. Nature 266:730–32. [aNRS]

R. M. Post , J. C. Ballenger & F. K. Goodwin (1980) Cerebrospinal fluid studies of neurotransmitter function in manic and depressive illness. In: Neurobiology of cerebrospinal fluid, ed. J. H. Wood . Plenum. [arNRS]

R. M. Post , R. H. Gerner , J. S. Carman , J. C. Gillin , D. C. Jimerson , F. K. Goodwin & W. E. Bunney Jr, (1978) Effects of a dopamine agonist piribedil in depressed patients. Archives of General Psychiatry 35(5):609–15. [aNRS]

R. M. Post , D. C. Jimerson , W. E. Bunney Jr, & F. K. Goodwin (1980) Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide. Psychopharmacology 67:297. [aNRS]

L. H. Price , D. S. Charney , Rubin, & G. R. Heninger (1986) Alpha-2 adrenergic receptor function in depression. Archives of General Psychiatry 43:849–58. [AW]

C. J. Pycock , R. W. Kerwin & C. J. Carter (1980a) Effect of 6-hydroxydopamine lesions of the medial prefrontal cortex on neurotransmitter systems in subcortical sites in the rat. Journal of Neurochemistry 34:9199. [PMB, PS, JPT]

C. J. Pycock , R. W. Kerwin & C. J. Carter (1980b) Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats. Nature 286:7477. [GEJ]

F. Quitkin , A. Rifkin & D. F. Klein (1979) Monoamine oxidase inhibitors: A review of antidepressant effectiveness. Archives of General Psychiatry 36:749–60. [aNRS]

A. Reches , V. Jackson-Lewis & S. Fahn (1984) Lithium does not interact with haloperidol in the dopaminergic pathways of the brain. Psychopharmacology 82:330–34. [aNRS]

M. Reibaud , G. Blanc , J-M. Studler , J. Glowinski , J-P. Tassin (1984) Nondopaminergic prefronto-cortical efferents modulate Dl receptors in the nucleus accumbens. Brain Research 305:4350. [PMB, GEJ, JPT]

G. P. Reynolds (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305:827–30. [MLM]

E. Richelson & M. Pfenning (1984) Blockade by anti-depressant and related compounds of biogenic amine uptake into rat brain synaptosomes: Most anti-depressants selectively block norepinephrine uptake. European Journal of Pharmacology 104:227–86. [aNRS]

S. C. Risch , N. H. Kalin , R. M. Cohen , J. Wecker , T. R. Insel , M. L. Cohen & D. L. Murphy (1981) Muscarinic cholinergic influences on ACTH and B-endorphin release mechanisms in human subjects. Peptides 2:9597. [arNRS]

S. C. Risch , N. H. Kalin & D. S. Janowsky (1981) Cholinergic challenges in affective illness: Behavioral and neuroendocrine correlates. Journal of Clinical Psychopharmacology 1:186–92. [aNRS]

A. H. Robbins (1976) Depression in patients with parkinsonism. British Journal of Psychiatry 128:141–45. [rNRS]

T. W. Robbins , J. L. Evenden , C. Ksir , P. Reading , S. Wood & M. Carli (1986) The effects of d-amphetamine, alpha-flupenthixol, and mesolimbic dopamine depletion on a test of attentional switching in the rat. Psychopharmacology 90:7278. [ARC]

T. W. Robbins & B. J. Everitt (1982) Functional studies of the central catecholamines. International Review of Neurobiology 23:303–65. [AEK]

T. W. Robbins & G. F. Koob (1980) Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature 285:409–12. [arNRS]

D. C. S. Roberts , M. E. Corcoran & H. C. Fibiger (1977) On the role of ascending catecholamine systems in intravenous self-administration of cocaine. Pharmacology, Biochemistry and Behavior 6:615–20. [arNRS]

D. C. S. Roberts , G. F. Koob , P. Klonoff & H. C. Fibiger (1980) Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacology, Biochemistry and Behavior 12:781–87. [aNRS]

D. C. S. Roberts , A. P. Zis & H. C. Fibiger (1975) Ascending catecholamine pathways and amphetamine induced locomotor activity: Importance of dopamine and apparent non-involvement of norepinephrine. Brain Research 93:441–54. [rNRS]

E. T. Rolls (1984) Responses of neurons in different regions of the striatum of the behaving monkey. In: The basal ganglia: Structure and function, ed. S. S. McKenzie , R. E. Kenn & L. N. Wilcock . Plenum. [arNRS]

E. T. Rolls , S. J. Thorpe , M. Boytim , I. Szabo & D. I. Perrett (1984) Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness. Neuroscience 12:1201–12. [rNRS]

F. T. Russchen , I. Bakst , D. G. Amaral & J. L. Price (1985) The amygdalostriatal projections in the monkey: An anterograde tracing study. Brain Research 329:241–57. [AEK]

J. Santamaria , E. Tolosa & A. Valles (1986) Parkinson's disease with depression: A possible subgroup of idiopathic parkinsonism Neurology 36:1130–33. [rNRS]

J. Schildkraut (1965) Catecholamine hypothesis of affective disorders. American Journal of Psychiatry 122:509–22. [aNRS]

R. A. Schutz , M. T. B. Schutz , O. A. Orsingher & I. Izquierdo (1979) Brain dopamine and noradrenaline levels in rats submitted to four different aversive tasks. Psychopharmacology 63:289–92. [aNRS]

R. S. Schwab & A. C. England (1958) Parkinson's disease. Journal of Chronic Diseases 8:488509. [rNRS]

P. Seeman , C. Ulpian , G. Bergeron , P. Riederer , K. Jellinger , E. Gabriel , G. P. Reynolds & W. W. Tourtellotte (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science 225:728–31. [arNRS]

A. D. Sherman & F. Petty (1982) Specificity of the learned helplessness animal model of depression. Pharmacology, Biochemistry and Behavior 16:449–54. [JAG]

C. Siegel , M. Waldo , G. Mizner , L. E. Adler & R. Freedman (1984) Deficits in sensory gating in schizophrenic patients and their relatives. Archives of General Psychiatry 41:607–13. [rNRS]

G. R. Siggins , B. J. Hoffer & O. Ungerstedt (1974) Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons. Life Sciences 15:779–92. [rNRS]

N. Sitaram & S. Gershon (1983) From animal models to clinical testing – promises and pitfalls. Progress in Neuro-Psychopharmacology and Biological Psychiatry 7:227–28. [PS]

S. H. Snyder (1972) Catecholamines in the brain as mediators of amphetamine psychosis. Archives of General Psychiatry 27:169–79. [aNRS]

C. Spyraki , H. C. Fibiger & A. G. Phillips (1982) Dopaminergic substrates of amphetamine-induced place preference conditioning. Brain Research 253:185–93. [aNRS]

D. A. Staunton , P. J. Magistretti , W. J. Shoemaker , S. N. Deyo & F. E. Bloom (1982) Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum: II. No effect on denervation or neurolepticinduced supersensitivity. Brain Research 232:401–12. [aNRS]

L. Stein & C. D. Wise (1971) Possible aetiology of schizophrenia: Progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science 171:1032–36. [aNRS]

Y. Stern & J. W. Langston (1985) Intellectual changes in patients with MPTP-induced parkinsonism. Neurology 35:1506–9.[aNRS]

D. E. Sternberg , M. B. Bowers Jr, G. R. Heninger & D. S. Charney (1983) Lithium prevents adaptation of brain dopamine systems to haloperidol in schizophrenic patients. Psychiatry Research 10:7986. [aNRS]

J. R. Stevens (1966) Psychiatric implications of psychomotor epilepsy. Archives ofCeneral Psychiatry 14:461–71. [aNRS]

J. R. Stevens (1973) An anatomy of schizophrenia? Archives of General Psychiatry 29:177–89. [aNRS, GFA, JRS]

J. R. Stevens (1984) Schizophrenia and the brain. Archives of General Psychiatry 41:816–17. [aNRS]

J. R. Stevens & A. Livermore (1978) Kindling of the mesolimbic dopamine system: Animal model of psychosis. Neurology 28:3646. [aNRS]

J. Stewart , H. de Wit & R. Eikelboom (1984) Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychological Review 91:251–68. [JAG]

L. Stinus , G. F. Koob , N. Ling , F. E. Bloom & M. Le Moal (1980) Locomotor activation induced by infusion of endorphins into the ventral tegmental area: Evidence for opiate interactions. Proceedings of the National Academy of Sciences of the United States of America 77:2323–27. [aNRS]

L. W. Swanson (1976) An autoradiographic study of the efferent connections of the preoptic regions in the rat. Journal of Comparative Neurology 167:227–56. [aNRS]

L. W. Swanson & W. M. Cowan (1975) A note on the connections and development of the nucleus accumbens. Brain Research 92:324–30. [aNRS]

L. W. Swanson & B. K. Hartman (1975) The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine βhydroxylase as a marker. Journal of Comparative Neurology 163:467506. [rNRS]

L. W. Swanson , G. J. Mogenson , C. R. Gerfen & P. Robinson (1984) Evidence for a projection from the lateral preoptic area and substantia innominata to the “mesencephalic locomotor region” in the rat Brain Research 295:161–78. [aNRS]

L. W. Swanson , P. E. Sawchenko , J. Rivier & W. Vale (1983) The organization of ovine corticotropin releasing factor (CRF) immunoreactive cells and fibres in the rat brain: Immunohistochemical study. Neuroendocrinology 36:165–86. [aNRS]

N. R. Swerdlow , D. L. Braff , M. A. Geyer & G. F. Koob (1986) Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biological Psychiatry 21:2333. [arNRS, JAG]

N. R. Swerdlow & G. F. Koob (1984) The neural substrates of apomorphinestimulated locomotor activity following denervation of the nucleus accumbens. Life Sciences 35:2537–44. [rNRS]

N. R. Swerdlow & G. F. Koob (1985) Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and corticotropin releasing factor (CRF) in the rat. Pharmacology Biochemistry & Behavior 23:303–7. [rNRS]

N. R. Swerdlow , L. W. Swanson & G. F. Koob (1984) Substantia innominata: Critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat. Neuroscience Letters 50:1924. [aNRS]

N. R. Swerdlow , F. J. Vaccarino , M. Amalric & G. F. Koob (1986) The neural substrates for the motor-activating properties of psychostimulants: A review of recent findings. In: Pharmacology Biochemistry and Behavior 25:233–48. [rNRS]

K. Taghzouti , H. Simon , A. Tazi , R. Dantzer & M. Le Moal (1985) The effect of 6-OHDA lesions of the lateral septum on schedule-induced polydipsia. Behavioral Brain Research 15:18. [rNRS]

C. A. Tamminga , G. Lucignani , L. F. Porrino , B. Littman , K. Thaker & L. Alphs (1984) Cholecystokinin: Potential peptidergic antipsychotic. Clinical Neuropharmacology 7 (Suppl. l):556557. [rNRS]

J. P. Tassin , L. Stinus , H. Simon , G. Blanc , A. M. Thierry , M. Le Moal , B. Cardo & J. Glowinski (1978) Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of fronto-cortical DA innervation in the rat. Brain Research 141:267–81. [JPT]

M. A. Taylor & R. Abrams (1973) The phenomenology of mania: A new look at some old patients. Archives of General Psychiatry 29:520–22. [AEK]

M. A. Taylor & R. Abrams (1975) Acute mania: Clinical and genetic study of responders and nonresponders to treatments. Archives of General Psychiatry 32:863–65. [AEK]

J. R. Taylor & T. W. Robbins (1984) Enhanced behavioral control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology 84:405–12. [AEK]

P. Tyrer & A. Mackay (1986) Schizophrenia: No longer a functional psychosis. Trends in Neurosciences 9:537–38. [MLM]

G. R. Uhl , J. C. Hedreen & D. L. Price (1985) Parkinson's disease: Loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions. Neurology 35:1215–18. [aNRS]

F. J. Vaccarino & G. F. Koob (1984) Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward. Neuroscience Letters 52:6166. [rNRS]

G. W. Van Hoesen & D. N. Pandya (1975) Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey: I. Frontal lobe afferents. Brain Research 95:2538. [aNRS]

T. Verimer , D. B. Goodale & J. P. Long (1980) Lithium effects on halopcridol-induced pre- and post-synaptic dopamine receptor supersensitivity. Journal of Pharmacy and Pharmacology 32:665–66. [aNRS]

N. D. Volkow , J. D. Brodie , A. P. Wolf , F. Gomez-Mont , R. Cancro , P. Van Celder , J. A. G. Russell & J. Overall (1986) Brain organization of schizophrenia. Journal of Cerebral Blood Flow and Metabolism 6:441–46. [AW]

M. C. Vrijmoed-de Vries & A. R. Cools (1986) Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats. Brain Research 364:7790. [ARC]

M. C. Waldo & R. Freedman (1986) Gating of auditory evoked responses in normal college students. Psychiatry Research 19:233–39. [rNRS]

J. W. Warburton (1967) Depressive symptoms in Parkinson patients referred for thalamotomy. Journal of Neurology, Neurosurgery and Psychiatry 30:368–70. [rNRS]

D. R. Weinberger , K. F. Berman & R. F. Zee (1986) Physiologic dysfunction of dorsolateral prefrontal cortex of schizophrenia I: Regional cerebral blood flow evidence. Archives of General Psychiatry 43:114–24. [GEJ, AEK]

I. Weiner , R. E. Lubow & J. Feldon (1984) Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats. Psychopharmacology 83:194–99. [JAC]

P. M. Whitaker , T. J. Crow & I. N. Ferrier (1981) Tritiated LSD binding in frontal cortex in schizophrenia. Archives of General Psychiatry 38:278–80. [aNRS]

E. Widerlov , P. W. Kalivas , M. H. Lewis , A. J. Prange Jr, & G. R. Breese (1983) Influence of cholecystokinin on central monoaminergie pathways Regulatory Peptides 6:99109. [rNRS]

P. Willner (1983a) Dopamine and depression: A review of recent evidence. I. Empirical studies. Brain Research Reviews 6:211–24. [aNRS, AEK]

P. Willner (1984) The validity of animal models of depression. Psychopharmacology 83:116. [aNRS]

R. A. Wise (1978) Catecholamine theories of reward: A critical review. Brain Research 152:180–83. [JAG]

E. A. Wolff , F. W. Putnam & R. M. Post (1985) Motor activity and affective illness. Archives of General Psychiatry 42:288–94. [aNRS]

D. F. Wong , H. N. Wagner Jr, L. E. Tune , R. F. Dannals , G. D. Pearlson , J. M. Links , C. A. Tamminga , E. P. Broussqlle , H. T. Ravert , A. A. Wilson , J. K. T. Toung , J. Malat , J. A. Williams , L. A. OTuama , S. H. Snyder M. J. Kuhar & A. Gjedde (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234:1558–62. [rNRS]

G. N. Woodruff , P. S. McCarthy & R. J. Walker (1976) Studies on the pharmacology of neurones in the nucleus accumbens of the rat. Brain Research 115:233–42. [rNRS]

R. J. Wyatt , M. A. Schwartz , E. Erdelyi & J. P. Barchas (1975) Dopamine-beta-hydroxylase activity in brains of chronic schizophrenic patients. Science 187:368–69. [aNRS]

K. I. Vamamoto & H. Kaneko (1986) Sequential changes of skin conductance activity in rats after intraventricular administration of 6-hydroxydopamine. Progress in Neuropsychopharmacology, and Biological Psychiatry 10:723–28. [rNRS]

E. H. Yeterian & G. W. van Hoesen (1978) Cortico-striate projections in the rhesus monkey: The organization of certain cortico-caudate connections. Brain Research 139:4363. [AEK]

R. A. Yokel & R. A. Wise (1976) Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology 48:311–18. [aNRS]

D. H. York (1967) The inhibitory actions of dopamine on neurons of the caudate nucleus. Brain Research 5:263–66. [rNRS]

L. Zaborszky , G. F. Alheid , M. C. Beinfield , L. E. Eiden , L. Heimer M. Palkovits (1985) Cholecystokinin innervation of the ventral striatum: A morphological and biochemical study. Neuroscience 14:427–53. [GFA]

M. J. Zigmond & E. M. Strieker (1984) Parkinson's disease: Studies with an animal model. Life Sciences 35:518. [AAG]

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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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