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Pharmacotherapy of School Refusal

  • Bruce J. Tonge (a1)
Extract

This paper reviews the role and indications for pharmacotherapy of children with school refusal. The psychopharmacological treatment of school refusal is based mainly on evidence of the effectiveness of certain drugs in the treatment of adult disorders. There is some evidence that tricyclic antidepressants and benzobiazepines may be specifically useful in the treatment of school refusal, but further research is warranted. Potentially serious side effects mean that drugs are best confined to cases where psychological treatments have not been effective or where drugs are used briefly as an adjunct to a broader psychological treatment plan. Drugs may also have a role in the specific treatment of comorbid conditions associated with school refusal. Any use of drugs should involve regular reviews to monitor response, compliance, and side effects.

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Centre for Developmental Psychiatry, Monash Medical Centre, 246 Clayton Road, Clayton VIC 3168, Australia
References
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Alessi, N., Naylo, M.W., Ghaziuddin, M., & Zubieta, J.K. (1994). Update on lithium carbonate therapy in children and adolescents. Journal of American Academy of Child and Adolescents Psychiatry, 33, 291304.
Aman, M.G., & Werry, J.S. (1982). Methylphenidate and diazepam in severe reading retardation. Journal of the American Academy of Child Psychiatry, 21, 3137.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
Ballenger, J.C. (1986). Pharmacotherapy of panic disorders. Journal of Clinical Psychiatry, 47, 2733.
Bangs, M.E., Petti, T.A., & Janus, M.D. (1994). Fluoxetine induced memory impairment in an adolescent. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 13031306.
Bartels, M.G., Varley, C.K., Mitchell, M.D., & Slam, S.J. (1991). Paediatric cardiovascular effects of Imipramine and desipramine. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 100103.
Berg, I., Nichols, K., & Pritchard, C. (1969). School phobia: Its classification and relationship to dependency. Journal of Child Psychology and Psychiatry, 10, 123141.
Berney, T., Kolvin, I., Bhate, S.R., Garside, R.F., Jeans, J., Kaye, B., & Scarth, L. (1981). School phobia: A therapeutic trial with clomipramine and short term outcomes. British Journal of Psychiatry, 138, 110118.
Bernstein, G. (1990). Anxiety disorders. In Garkfinkel, B.D., Carlson, G.A., & Weller, E.B. (Eds.), Psychiatric disorders in children and adolescents (pp. 6483). Philadelphia: Saunders.
Bernstein, G.A., Garfinkel, B.D., & Borchardt, C.M. (1990). Comparative studies of pharmacotherapy for school refusal. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 773784.
Boulos, C., Cutcher, S., Gardner, D., & Young, E. (1992). An open naturalistic trial of fluoxetine in adolescents and young adults with treatment resistant major depression. Journal of Child and Adolescent Psychopharmacology, 2, 103111.
Carr, R. (1983). The role of medication in the treatment of the disturbed child. In Steinhauer, P.D. & Rae-Grant, Q. (Eds.), Psychological problems of the child and the family (pp. 635663). New York: Basic Books.
D'Amato, G. (1962). Chlordiazepoxide in the treatment of school phobia. Diseases of the Nervous System, 23, 292295.
DeLong, R.G., & Aldershof, A.L. (1987). Long term experiences with lithium treatment in childhood: Correlation with clinical diagnosis. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 389394.
Depression Guideline Panel. (1993). Depression in primary care: Treatment of major depression (Vols. 1 and 2) Clinical Practice Guideline, No. 5 (AHCPR publication No. 93–0551). Rockville, MD: US Department of Health & Human Services, Public Health Service, Agency for Health Care Policy & Research.
Desai, N., Taylor-Davies, A., & Barnett, D. (1983). The effects of Diazepam and Oxpranolol on short term memory in individuals of high and low state anxiety. British Journal of Clinical Pharmacology, 15, 197201.
Emslie, G.J., Rush, A.J., Weinberg, W.A., Kowatch, R.A., Hughes, C.W., Carmody, T., & Rintelmann, J. (1997). A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Archives of General Psychiatry, 54, 10311037.
Famularo, R., Kinscheroff, R., & Fenton, T. (1988). Propranolol treatment for childhood post traumatic stress disorder, acute type. American Journal of the Diseases of Childhood, 142, 12441247.
Frommer, E.A. (1967). Treatment of childhood depression with antidepressant drugs. British Medical Journal, 1, 729732.
Gammon, G.D., & Brown, T.E. (1993). Fluoxetine and methylphenidate in combination for treatment of attention deficit disorder and comorbid depressive disorder. Journal of Child and Adolescent Psychopharmacology, 3, 110.
Garfield, S.L., Helper, M.M., Wilcott, R.C., & Muffly, R. (1962). Effects of chlorpromazine on behaviour in emotionally disturbed children. Journal of Nervous and Mental Disease, 135, 147154.
Gittelman-Klein, R., & Klein, D.F. (1971). Controlled Imipramine treatment of school phobia. Archives of General Psychiatry, 25, 204207.
Iancu, I., Ratzoni, G., Weitzman, A., & Apeter, A. (1992). More fluoxetine experience. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 755756.
Janicak, P.G., David, J.M., Preskorn, S.H., & Ayd, F.J. (1993). Treatment with antidepressants. In Janicak, P.G. (Ed.), Principles and practice of psychopharmacotherapy (pp. 209292). Baltimore: Williams & Wilkins.
King, N.J., Ollendick, T.H., & Tonge, B.J. (1995). School refusal: Assessment and treatment. Boston: Allyn & Bacon.
King, R.A., Riddle, M.A., Chappell, P.B., Hardin, M.T., Anderson, G.M., Lerubroso, P., & Scahill, L. (1991). Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 179186.
Klein, R.G., Koplewicz, H.S., & Kanner, A. (1992). Imipramine treatment of children with separation anxiety disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 2128.
Kraft, I.A., Ardali, C., Duffy, J.H., Hart, J.T., & Pearce, P. (1965). A clinical study of chlordiazepoxide used in psychiatric disorders in children. International Journal of Neuropsychiatry, 1, 433437.
Lucas, A.R., & Pasley, F.C. (1969). Psychoactive drugs in the treatment of emotionally disturbed children: Haloperidol and diazepam. Comprehensive Psychiatry, 10, 376386.
Mant, A., Lansbury, G., & Bridges-Webb, C. (1987). Trends in psychotropic drug prescribing in Australia. Medical Journal of Australia, 146, 208210.
Montgomery, S.A., Henry, J., McDonald, G., Dinnan, T., Lader, M., Hinmarch, I., Clare, A., & Nutt, D. (1994). Selective serotonin reuptake inhibitors: Meta-analysis of discontinuation rates. International Journal of Clinical Psychopharmacology, 9, 4753.
National Health and Medical Research Council. (1997). Depression in young people: Clinical practice guidelines. Canberra: Australian Government Publishing Service.
Papatheodorou, G., & Kutcher, S.P. (1993). Divalproex sodium treatment in late adolescent and young adult acute mania. Psychopharmacological Bulletin, 29, 213219.
Riddle, M.A., Nelson, J.C., Kleinman, C.S., Rasmusson, A., Leckman, J.F., King, R.A., & Cohen, D.J. (1991). Sudden death in children receiving Norpramin: A review of three reported cases and commentary. Journal of the American Academy of Child and Adolescent Psychiatry, 20, 104108.
Ryan, N.D. (1992). The pharmacologic treatment of child and adolescent depression. Paediatric Psychopharmacology, 15, 2940.
Simeon, J.G., Ferguson, H.B., Knott, V., Roberts, N., Gauthier, B., Dubois, B.A., & Wiggins, D. (1992). Clinical cognitive and neurophysiological effects of alprazolam in children and adolescents with over-anxious and avoidant disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 2933.
Sleator, E.K. (1985). Measurement of compliance. Psychomarphacological Bulletin, 21, 10891093.
Strober, M., Freeman, R., & Rigali, J. (1990). The pharmacotherapy of depressive illness in adolescents: I. An open label trial of Imipramine. Psychopharmacological Bulletin, 26, 84.
Strober, M., Morrell, W., Lampert, C., & Burroughs, J. (1990). Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar 1 illness. American Journal of Psychiatry, 147, 457461.
Tiller, J., Maguire, K., & Davies, B. (1990). A sequential double blind controlled study of moclobemide and mianserin in elderly depressed patients. International Journal of Geriatric Psychiatry, 5, 199204.
Venkataraman, S., Naylor, M.W., & King, C.A. (1992). Mania associated with fluoxetine treatment in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 276281.
Viesselman, J.O., Yaylayan, S., Weller, E.B., & Weller, R.A. (1993). Antidysthymic drugs. In Werry, J.S. & Aman, M.G. (Eds.), Practitioner's guide to psychoactive drugs for children and adolescents (pp. 239268). New York: Plenum.
Waters, B. (1990). Pharmacological and other physical treatments. In Tonge, B.J.Burrows, G., & Werry, J. (Eds.), Handbook of studies on child psychiatry (pp. 388402). Amsterdam: Elsevier.
Werry, J.S. (1993). A guide for practitioners, professionals and public. In Werry, J.S. & Aman, M.G. (Eds.), Practitioner's guide to psychoactive drugs for children and adolescents (pp. 320). New York: Plenum.
World Health Organization. (1992). The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines. Geneva: Author.
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Behaviour Change
  • ISSN: 0813-4839
  • EISSN: 2049-7768
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