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Prescribing clozapine and rifampicin: clinical impact of their interaction

  • Caroline Parker (a1)
Summary

The predictable pharmacokinetic drug interaction between clozapine and rifampicin is listed in most standard reference texts but little detail is given or emphasis on its clinical significance. The interaction is based on theoretical knowledge of both drugs; to date just two case reports have been published. This article describes a third case demonstrating the significance of this interaction. This was potentially devastating for the patient who required an extended psychiatric admission. The enzyme induction was so potent that the dose of clozapine had to be increased approximately sixfold. Careful management of this significant interaction is essential for effective patient care.

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Copyright
This is an open-access article published by the Royal College of Psychiatrists and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Correspondence to Caroline Parker (caroline.parker@nhs.net)
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Declaration of interest

None.

Footnotes
References
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BJPsych Bulletin
  • ISSN: 2056-4694
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Prescribing clozapine and rifampicin: clinical impact of their interaction

  • Caroline Parker (a1)
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