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A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model

  • Paul A. Davis (a1), Vihas T. Vasu (a2), Kishorchandra Gohil (a2), Hyunsook Kim (a1), Imran H. Khan (a3), Carroll E. Cross (a2) and Wallace Yokoyama (a4)
  • DOI: http://dx.doi.org/10.1017/S0007114511007288
  • Published online: 16 January 2012
Abstract

Prostate cancer (PCa) has been linked to fat intake, but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of whole walnuts were compared to those of an elevated fat (20 % of energy as soyabean oil) diet with matched macronutrients, tocopherols as well as a low-fat (8 % of energy as soyabean oil) diet. Mice, starting at 8 weeks of age, consumed one of the three different diets ad libitum; and prostates, livers and blood were obtained after 9, 18 or 24 weeks of feeding. No differences were observed in whole animal growth rates in either high-fat (HF) diet group, but prostate tumour weight and growth rate were reduced in the walnut diet group. Walnut diet group prostate weight, plasma insulin-like growth factor 1, resistin and LDL were lower at 18 weeks, while no statistically significant prostate weight differences by diet were seen at 9 or 24 weeks. Multiple metabolites in the livers differed by diet at 9 and 18 weeks. The walnut diet's beneficial effects probably represent the effects of whole walnuts' multiple constituents and not via a specific fatty acid or tocopherols. Moreover, as the two HF diets had dissimilar effects on prostate tumour growth rate and size, and yet had the same total fat and tocopherol composition and content, this suggests that these are not strongly linked to PCa growth.

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*Corresponding author: Dr P. A. Davis, +1 530 752 8966, email padavis@ucdavis.edu
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2EL Escobar , MC Gomes-Marcondes & HF Carvalho (2009) Dietary fatty acid quality affects AR and PPARgamma levels and prostate growth. Prostate 69, 548558.

3MD Brown , C Hart , E Gazi , et al. (2010) Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer. Br J Cancer 102, 403413.

4IM Berquin , Y Min , R Wu , et al. (2007) Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest 117, 18661875.

5AC Reese , V Fradet & JS Witte (2009) Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer. J Nutrigenet Nutrigenomics 2, 149158.

6AR Kristal , KB Arnold , ML Neuhouser , et al. (2010) Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol 172, 566577.

7S Vissapragada , A Ghosh , L Ringer , et al. (2010) Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2x Pten(+/ − ) preclinical mouse model. Cell Cycle 9, 18241829.

8KM Szymanski , DC Wheeler & LA Mucci (2010) Fish consumption and prostate cancer risk: a review and meta-analysis. Am J Clin Nutr 92, 12231233.

10KJ Spaccarotella , PM Kris-Etherton , WL Stone , et al. (2008) The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J 7, 13.

11SJ Freedland & WJ Aronson (2009) Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol 19, 263267.

12JC Lloyd , JA Antonelli , TE Phillips , et al. (2010) Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model. J Urol 183, 16191624.

14WE Hardman , G Ion , JA Akinsete , et al. (2011) Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Nutr Cancer 63, 960970.

15PA Nguewa & A Calvo (2010) Use of transgenic mice as models for prostate cancer chemoprevention. Curr Mol Med 10, 705718.

18LS Maguire , SM O'Sullivan , K Galvin , et al. (2004) Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int J Food Sci Nutr 55, 171178.

21A Hsu , TM Bray , WG Helferich , et al. (2010) Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp Biol Med (Maywood) 235, 9097.

22DR Jacobs Jr, MD Gross & LC Tapsell (2009) Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr 89, 1543S1548S.

24S Gupta , VM Adhami , M Subbarayan , et al. (2004) Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 64, 33343343.

25J Qi , K Nakayama , RD Cardiff , et al. (2010) Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18, 2338.

26R Xu , WH Yokoyama , D Irving , et al. (1998) Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. Atherosclerosis 137, 2936.

27MB Brown & AB Forsythe (1974) Robust tests for equality of variances. J Amer Statist Assoc 69, 364367.

28NM Laird & JH Ware (1982) Random-effects models for longitudinal data. Biometrics 38, 963974.

30VM Adhami , IA Siddiqui , N Ahmad , et al. (2004) Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res 64, 87158722.

31L Wang , MJ Bonorden , GX Li , et al. (2009) Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. Cancer Prev Res (Phila Pa) 2, 484495.

32L Wang , J Zhang , Y Zhang , et al. (2011) Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium. Prostate 71, 14291440.

35TE Quiner , HL Nakken , BA Mason , et al. (2011) Soy content of basal diets determines the effects of supplemental selenium in male mice. J Nutr 141, 21592165.

36J Zhang , L Wang , G Li , et al. (2011) Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds. Nutr Cancer 63, 778789.

37TJ Key (2011) Diet, insulin-like growth factor-1 and cancer risk. Proc Nutr Soc (epublication ahead of print version 3 May 2011).

38AS Prasad , H Mukhtar , FW Beck , et al. (2010) Dietary zinc and prostate cancer in the TRAMP mouse model. J Med Food 13, 7076.

39M Pollak (2008) Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8, 915928.

40MJ Bonorden , OP Rogozina , CM Kluczny , et al. (2009) Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice. Nutr Cancer 61, 265275.

41JA Thomas 2nd, JA Antonelli , JC Lloyd , et al. (2010) Effect of intermittent fasting on prostate cancer tumor growth in a mouse model. Prostate Cancer Prostatic Dis 13, 350355.

43A Gualberto & M Pollak (2009) Clinical development of inhibitors of the insulin-like growth factor receptor in oncology. Curr Drug Targets 10, 923936.

44N Majeed , MJ Blouin , PJ Kaplan-Lefko , et al. (2005) A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model. Oncogene 24, 47364740.

45M Anzo , LJ Cobb , DL Hwang , et al. (2008) Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res 68, 33423349.

46BW Sutherland , SE Knoblaugh , PJ Kaplan-Lefko , et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res 68, 34953504.

47K Raina , MJ Blouin , RP Singh , et al. (2007) Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 67, 1108311091.

49WH Chung , TH Kim , IH Chang , et al. (2009) Relation of resistin to prostate cancer differentiation and aggressiveness. Korean J Urol 50, 540546.

50HJ Kim , YS Lee , EH Won , et al. (2010) Expression of resistin in the prostate and its stimulatory effect on prostate cancer cell proliferation. BJU Int 108, E77E83.

52H Grosman , B Fabre , V Mesch , et al. (2010) Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer. Aging Male 13, 8792.

54KR Solomon , K Pelton , K Boucher , et al. (2009) Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol 174, 10171026.

55G Llaverias , C Danilo , Y Wang , et al. (2010) A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol 177, 31803191.

56JR Krycer , I Kristiana & AJ Brown (2009) Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3. PLoS ONE 4, e8496.

57RM Krauss (2010) Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol 21, 305311.

58DE Kok , JG van Roermund , KK Aben , et al. (2011) Blood lipid levels and prostate cancer risk; a cohort study. Prostate Cancer Prostatic Dis 14, 340345.

59C Ohlsson , S Mohan , K Sjogren , et al. (2009) The role of liver-derived insulin-like growth factor-I. Endocr Rev 30, 494535.

60TM Brasky , C Till , E White , et al. (2011) Serum phospholipid fatty acids and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol 173, 14291439.

61GP Risbridger , ID Davis , SN Birrell , et al. (2010) Breast and prostate cancer: more similar than different. Nat Rev Cancer 10, 205212.

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