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Effect of n-3 PUFA on left ventricular remodelling in chronic heart failure: a systematic review and meta-analysis

Published online by Cambridge University Press:  04 March 2022

Jing Liu Open the ORCID record for Jing Liu [Opens in a new window] ,
Qingshu Meng ,
Liang Zheng ,
Ping Yu ,
Hao Hu ,
Rulin Zhuang ,
Xinyu Ge ,
Zhongmin Liu ,
Xiaoting Liang  and
Xiaohui Zhou
Jing Liu
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Department of Burn & Plastic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, People’s Republic of China
Qingshu Meng
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Liang Zheng
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Ping Yu
Affiliation:
Department of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Hao Hu
Affiliation:
Department of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Rulin Zhuang
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Xinyu Ge
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Zhongmin Liu
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
Xiaoting Liang*
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, People’s Republic of China
Xiaohui Zhou*
Affiliation:
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
*
*Corresponding authors: Xiaoting Liang, email liangxt@tongji.edu.cn; Xiaohui Zhou, email zxh100@tongji.edu.cn
*Corresponding authors: Xiaoting Liang, email liangxt@tongji.edu.cn; Xiaohui Zhou, email zxh100@tongji.edu.cn
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Abstract

Accumulating evidence suggests that supplementation of n-3 PUFA was associated with reduction in risk of major cardiovascular events. This meta-analysis was to systematically evaluate whether daily supplementation and accumulated intake of n-3 PUFA are associated with improved left ventricular (LV) remodelling in patients with chronic heart failure (CHF). Articles were obtained from Pubmed, Clinical key and Web of Science from inception to January 1 in 2021, and a total of twelve trials involving 2162 participants were eligible for inclusion. The sources of study heterogeneity were explained by I2 statistic and subgroup analysis. Compared with placebo groups, n-3 PUFA supplementation improved LV ejection fraction (LVEF) (eleven trials, 2112 participants, weighted mean difference (WMD) = 2·52, 95 % CI 1·25, 3·80, I2 = 87·8 %) and decreased LV end systolic volume (five studies, 905 participants, WMD = –3·22, 95 % CI 3·67, −2·77, I2 = 0·0 %) using the continuous variables analysis. Notably, the high accumulated n-3 PUFA dosage groups (≥ 600 g) presented a prominent improvement in LVEF, while the low and middle accumulated dosage (≤ 300 and 300–600 g) showed no effects on LVEF. In addition, n-3 PUFA supplementation decreased the levels of pro-inflammatory mediators including TNF-α, IL-6 (IL-6) and hypersensitive c-reactive protein. Therefore, the present meta-analysis demonstrated that n-3 PUFA consumption was associated with a substantial improvement of LV function and remodelling in patients subjected to CHF. The accumulated dosage of n-3 PUFA intake is vital for its cardiac protective role.

Keywords

n-3 PUFAChronic heart failureLeft ventricular remodellingSystematic reviewmeta-analysis
Type
Systematic Review and Meta-Analysis
Information
British Journal of Nutrition , Volume 129 , Issue 9 , 14 May 2023 , pp. 1500 - 1509
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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