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British Journal of Nutrition British Journal of Nutrition

Article contents

Acute effects of ingesting glucose solutions on blood and plasma volume

Published online by Cambridge University Press:  08 October 2008

Gethin H. Evans ,
Susan M. Shirreffs  and
Ronald J. Maughan
Gethin H. Evans
Affiliation:
School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
Susan M. Shirreffs*
Affiliation:
School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
Ronald J. Maughan
Affiliation:
School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
*
*Corresponding author: Dr Susan M. Shirreffs, fax +44 1509 226301, email s.shirreffs@lboro.ac.uk
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Abstract

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The change in blood and plasma volume following ingestion of glucose solutions of varying concentrations was estimated in twelve healthy male volunteers. Subjects consumed, within a 5 min period, 600 ml of a solution containing 0, 2, 5 or 10 % glucose with osmolalities of 0 (sd 0), 111 (sd 1), 266 (sd 7) and 565 (sd 5) mOsm/kg, respectively. Blood samples were collected over the course of 1 h after ingestion at intervals of 10 min. After ingestion of the 2 % glucose solution, plasma volume increased from baseline levels at 20 min. Plasma volume decreased from baseline levels at 10 and 60 min after ingestion of the 10 % glucose solution. Heart rate was elevated at 10 and 60 min after ingestion of the 10 % glucose solution and decreased at 30 and 40 min after ingestion of the 2 % glucose solution relative to the average heart rate recorded before drinking. It is concluded that ingestion of hypertonic, energy-dense glucose solutions results in a decrease in plasma and extracellular fluid volume, most likely due to the net secretion of water into the intestinal lumen.

Keywords

Plasma volumeExtracellular fluid volumeSolution osmolalityIntestinal absorption
Type
Full Papers
Information
British Journal of Nutrition , Volume 101 , Issue 10 , 28 May 2009 , pp. 1503 - 1508
Copyright
Copyright © The Authors 2008

References

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