Anila, L & Vijayalakshmi, NR (2002) Flavonoids from Emblica officinalis and Mangifera indica – effectiveness for dyslipidemia. J Ethnopharmacol 79, 81–87.
Anila, L & Vijayalakshmi, NR (2003) Antioxidant action of flavonoids from Mangifera indica and Emblica officinalis in hypercholesterolemic rats. Food Chemistry 83, 569–574.
Asmawi, MZ, Kankaanranta, H, Moilanen, E & Vapaatalo, H (1993) Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. J Pharm Pharmacol 45, 581–584.
Baldwin, AS (2001) The transcription factor NF-κB and human disease. J Clin Invest 107, 3–6.
Bandyopadhyay, SK, Pakrashi, SC & Pakrashi, A (2000) The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. J Ethnopharmacol 70, 171–176.
Barbier, O, Torra, P, Duguay, Y, Blanquart, C, Fruchart, JC, Glineur, C & Staels, B (2002) Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 22, 717–726.
Beckman, KB & Ames, BN (1998) The free radical theory of aging matures. Physiol Rev 78, 547–581.
Berger, JP, Akiyama, TE & Meinke, PT (2005) PPARs: therapeutic targets for metabolic disease. Trends Pharmacol Sci 26, 244–251.
Bhattacharya, A, Chatterjee, A, Ghosal, S & Bhattacharya, SK (1999) Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol 37, 676–680.
Blanquart, C, Barbier, O, Fruchart, JC, Staels, B & Glineur, C (2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol 85, 267–273.
Buege, JA & Aust, SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52, 302–306.
Chan, SL & Yu, VC (2004) Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities. Clin Exp Pharmacol Physiol 31, 119–128.
Choi, YH, Lee, SJ, Nguyen, P, Jang, JS, Lee, J, Wu, ML, Takano, E, Maki, M, Henkard, PA & Trepel, JB (1997) Regulation of cyclin D1 by calpain protease. J Biol Chem 272, 28479–28484.
De la Lastra, CA & Villegas, I (2005) Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 49, 405–430.
Deokar, AB (1998) Medicinal Plants Grown at Rajagaon, 1st ed., pp. 48–49, Pune: DS Manav Vikas Foundation.
El-Mekkawy, S, Meselhy, MR, Kusumoto, IT, Kadota, S, Hattori, M & Namba, T (1995) Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull 43, 641–648.
Ferrari, AU, Radaelli, A & Centola, M (2003) Aging and the cardiovascular system. J Appl Physiol 95, 2591–2597.
Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497–509.
Ghosal, S, Tripathi, VK & Chauhan, S (1996) Active constituents of Emblica officinalis: Part 1 – The chemistry and antioxidant effects of two new hydrolysable tannins, emblicanin A and B. Indian J Chem 35B, 941–948.
Green, DR & Reed, JC (1998) Mitochondria and apoptosis. Science 281, 1309–1312.
Halliwell, B & Chirico, S (1993) Lipid peroxidation: its mechanism measurement and significance. Am J Clin Nutr 57, 715–725.
Hockenbery, DM, Oltvai, ZN, Yin, XM, Milliman, CL & Korsmeyer, SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241–251.
Inoue, I, Noji, S, Shen, MZ, Takahashi, K & Katayama, S (1997) The peroxisome proliferator-activated receptor α (PPARα) regulates the plasma thiobarbituric acid-reactive substance (TBARS) level. Biochem Biophys Res Commun 237, 606–610.
Inoue, I, Itoh, F, Aoyagi, S, et al. (2002) Fibrate and statin synergistically increase the transcriptional activities of PPARα/RXRα and decrease the transactivation of NFκB. Biochem Biophys Res Commun 290, 131–139.
Itzhaki, RF & Gill, DM (1964) A micro-biuret method for estimating proteins. Anal Biochem 9, 401–410.
Johnson, D & Lardy, H (1967) Isolation of liver or kidney mitochondria. Methods Enzymol X, 94–96.
Jose, JK & Kuttan, R (1995) Antioxidant activity of E. officinalis. J Clin Biochem Nutr 19, 63–70.
Jose, JK, Kuttan, G & Kuttan, R (2001) Antitumour activity of Emblica officinalis. J Ethnopharmacol 75, 65–69.
Jung, K & Pergande, M (1985) Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria. FEBS Lett 183, 167–169.
Kim, CH, Park, DH, Chung, A, Zou, Y, Jung, KJ, Sung, BK, Yu, BP & Chung, HY (2004) Proteomic analysis of post-mitochondrial fractions of young and old rat kidney. Exp Geront 39, 1155–1168.
Kim, HJ, Yokozawa, T, Kim, HY, Tohda, C, Rao, TP & Juneja, LR (2005) Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats. J Nutr Sci Vitaminol 51, 413–418.
Kim, HJ, Yu, BP & Chung, HY (2002) Molecular exploration of age-related NF-κB/IKK downregulation by calorie restriction in rat kidney. Free Radic Biol Med 32, 991–1005.
Knight, JA (2001) The biochemistry of aging. Adv Clin Chem 35, 1–62.
Lacko, AG & Davis, JL (1979) Age-related changes in rat and primate plasma cholesterol metabolism. J Am Geriatr Soc 5, 212–217.
Lavrovsky, Y, Chatterjee, B, Clark, RA & Roy, AK (2000) Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 35, 521–532.
Li, Q & Verma, IM (2002) NF-κB regulation in the immune system. Nat Immunol 2, 725–734.
Lin, MT & Beal, MF (2003) The oxidative damage theory of aging. Clin Neurosci Res 2, 305–315.
Naito, C & Yamanaka, T (1978) Atherosclerotic disorder and lipid peroxidation. Jpn J Geriatr 15, 187–191.
Pahan, K, Jana, M, Liu, X, Taylor, BS, Wood, C & Fischer, SM (2002) Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric oxide synthase in human astrocytes. J Biol Chem 277, 45984–45991.
Parini, P, Angelin, B & Rudling, M (1999) Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats. Arterioscler Thromb Vasc Biol 19, 832–839.
Perry, LM (1980) Medicinal Plants of East and South East Asia: Attributed Properties and Uses. Cambridge, MA: MIT Press.
Peters, JM, Hennuyer, N, Staels, B, Fruchart, JC, Fievet, C, Gonzalez, FJ & Auwerx, J (1997) Alteration in lipoprotein metabolism in peroxisome proliferator-activated receptor-α deficient mice. J Biol Chem 272, 28307–28312.
Poon, HF, Calabrese, V, Scapagnini, G & Butterfield, DA (2004) Free radicals and brain aging. Clin Geriatr Med 20, 329–359.
Poynter, ME & Daynes, RA (1998) Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273, 32833–32841.
Ricote, M & Glass, CK (2001) New roles for PPARs in cholesterol homeostasis. Trends Pharmacol Sci 22, 441–443.
Sabu, MC & Kuttan, R (2002) Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol 81, 155–160.
Sakurai, H, Hisada, Y, Ueno, M, Sugiura, M, Kawashima, K & Sugita, T (1996) Activation of transcription factor NF-κB in experimental glomerulonephritis in rats. Biochim Biophys Acta 1316, 132–138.
Samhan-Arias, AK, Martín-Romero, FJ & Gutiérrez-Merino, C (2004) Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Free Radic Biol Med 37, 48–61.
Sanguino, E, Ramón, M, Michalik, L, Wahli, W, Alegret, M, Sánchez, RM, Vázquez-Carrera, M & Laguna, JC (2004 a) Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARα. Biochem Pharmacol 67, 157–166.
Sanguino, E, Roglans, N, Alegret, M, Sánchez, RM, Vázquez-Carrera, M & Laguna, JC (2004b) Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs. Biochem Pharmacol 68, 1411–1421.
Sanguino, E, Roglans, N, Alegret, M, Sánchez, RM, Vázquez-Carrera, M & Laguna, JC (2005) Atorvastatin reverses age-related reduction in rat hepatic PPARα and HNF-4. Br J Pharmacol 145, 853–861.
Spencer, NF, Poynter, ME, Im, SY & Daynes, RA (1997) Constitutive activation of NF-κB in an animal model of aging. Int Immunol 9, 1581–1588.
Thakur, CP (1985) Emblica officinalis reduces serum, aortic and hepatic cholesterol in rabbits. Experientia 41, 423–424.
Toth, MJ & Tehernof, A (2000) Lipid metabolism in the elderly. Eur J Clin Nutr 54, S121–S125.
Wickens, AP (2001) Ageing and the free radical theory. Respir Physiol 128, 379–391.
Williams, RJ, Spencer, JPE & Rice-Evans, C (2004) Flavonoids: antioxidants or signaling molecule? Free Radic Biol Med 36, 838–849.
Yoon, SO, Yun, CH & Chung, AS (2002) Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Dev 123, 1597–1604.
Yu, BP & Chung, HY (2001) Oxidative stress and vascular aging. Diabetes Res Clin Pract 54, S73–S80.
Yu, BP & Chung, HY (2006) Adaptive mechanisms to oxidative stress during aging. Mech Ageing Dev 127, 436–443.
Zhang, YJ, Tanaka, T, Yang, CR & Kouno, I (2001) New phenolic constituents from the fruit juice Phyllanthus emblica. Chem Pharm Bull 49, 537–540.