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Antioxidative factors in milk

  • Helena Lindmark-Månsson (a1) (a2) and B. Åkesson (a2)
Abstract

Lipid auto-oxidation in milk is affected by a complex interplay of pro- and antioxidants. Several of these compounds are also important nutrients in the human diet and may have other physiological effects in the gastrointestinal tract and other tissues. Among antioxidative enzymes superoxide dismutase catalyses the dismutation of superoxide anion to hydrogen peroxide. The degradation of hydrogen peroxide can be catalysed by catalase and the selenoprotein glutathione peroxidase. The latter enzyme can also degrade lipid peroxides. Lactoferrin may have an important role by binding pro-oxidative iron ions. The occurrence of different forms of these antioxidative proteins in milk and available data on their functional role are reviewed. More remains to be learnt of individual compounds and as an example the potential role of seleno compounds in milk is virtually unknown. Antioxidative vitamins in milk can provide an important contribution to the daily dietary intake. Moreover vitamin E and carotenoids act as fat-soluble antioxidants, e.g. in the milk fat globule membrane, which is regarded as a major site of auto-oxidation. Vitamin C is an important water-soluble antioxidant and interacts in a complex manner with iron and fat-soluble antioxidants. The concentrations of these compounds in milk are affected by cow feeding rations and milk storage conditions. Since milk contains a number of antioxidants many reactions are possible and the specific function of each antioxidant cannot easily be defined. There are indications that other compounds may have antioxidative function and measurement of total antioxidative capacity should be a useful tool in evaluating their relative roles.

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Corresponding author
*Corresponding author: Helena Lindmark-Mansson, fax +46 46 137 040
References
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Alajos, MS & Romero, CD (1995) Selenium concentration in milks Food Chemistry 52, 118.
Andersson, I & Öste, R (1992) Loss of ascorbic acid, folacin and vitamin B12, and changes in oxygen content of UHT milk. I. Introduction and methods Milchwissenschaft 47, 223224.
Andersson, I & Öste, R (1992) Loss of ascorbic acid, folacin and vitamin B12, and changes in oxygen content of UHT milk. II. Results and discussion Milchwissenschaft 47, 299302.
Andersson, I, Öste, R (1994) Nutritional quality of pasteurized milk. Vitamin B12, folacin and ascorbic acid content during storage International Dairy Journal 4, 161172.
Asada, K (1976) Occurrence of superoxide dismutase in bovine milk Agricultural Biology and Chemistry 40, 16591660.
Avissar, N, Slemmon, JR, Palmer, IS & Cohen, HJ (1991) Partial sequence of human plasma glutathione peroxidase and immunological identification of milk glutathione peroxidase as the plasma enzyme Journal of Nutrition 121, 12431249.
Barrefors, P, Granelli, K, Appelqvist, L-Å, Björck, L (1995) Chemical characterization of raw milk samples with and without oxidative off-flavor Journal of Dairy Science 78, 26912699.
Bhattacharya, ID, Picciano, MF & Milner, JA (1988) Characteristics of human milk glutathione peroxidase Biological Trace Element Research 18, 5970.
Bihel, S, Birlouez-Aragon, I (1998) Inhibition of tryptophan oxidation in the presence of iron-vitamin C by bovine lactoferrin International Dairy Journal 8, 637641.
Bilic, N (1991) Assay of both ascorbic and dehydroascorbic acid in dairy foods by high-performance liquid chromatography using precolumn derivatization with methoxy- and ethoxy-1,2-phenylenediamine Journal of Chromatography 543, 357374.
Buettner, GR (1993) The pecking order of free radicals and antioxidants: lipid peroxidation, α-tocopherol, and ascorbate Archives of Biochemistry and Biophysics 300, 535543.
Champagne, ET, Hinojosa, O & Clemetson, CAB (1990) Production of ascorbate free radicals in infant formulas and other media Journal of Food Science 55, 11331136.
Charmley, E & Nicholson, JWG (1993) Injectable α-tocopherol for control of oxidized flavour in milk from dairy cows Canadian Journal of Animal Science 73, 381392.
Charmley, E, Nicholson, JWG & Zee, JA (1993) Effect of supplemental vitamin E and selenium in the diet on vitamin E and selenium levels and control of oxidized flavor in milk from Holstein cows Canadian Journal of Animal Science 73, 453457.
Debski, B, Piccano, MF & Milner, JA (1987) Selenium content and distribution of human, cow and goat milk Journal of Nutrition 117, 10911097.
Evans, HJ, Steinmann, HM & Hill, RL (1974) Bovine erythrocyte superoxide dismutase. Isolation and characterisation of tryptic, cyanogen bromide and maleyated tryptic peptides Journal of Biological Chemistry 249, 73157325.
Flachowsky, G, Schaarmann, G, Jahreis, G, Schöne, F, Richter, GH, Böhme, H & Schneider, A (1997) Einfluss der Vefütterung von Ölsaaten und Nebenprodukten aus Ölsaaten auf die Vitamin E-Konzentration in Tierprodukten Fett/Lipid 99, 5560.
Flohé, L, Günzler, WA & Schock, HH (1973) Glutathione peroxidase: a selenoenzyme FEBS Letters 32, 132134.
Focant, M, Mignolet, E, Marique, M, Clabots, F, Breyne, T, Dalemans, D & Larondelle, Y (1998) The effect of vitamin E supplementation of cow diets containing rapeseed and linseed on the prevention of milk fat oxidation Journal of Dairy Science 81, 10951101.
Fridovich, I (1974) Superoxide dismutases Advances in Enzymology 41, 3597.
Fridovich, I (1986) Superoxide dismutases Advances in Enzymology 58, 6197.
Gagnon, M, Hunting, WM & Esselen, WB (1959) New method for catalase determination Analytical Chemistry 31, 144146.
Granelli, K, Björck, L, Appelqvist, L-Åring; (1994) The variation of superoxide dismutase (SOD) and xanthine oxidase (XO) activities in milk using an improved method to quantitate SOD activity Journal of the Science of Food and Agriculture 67, 8591.
Griffiths, MW (1986) Use of milk enzymes as indices of heat treatment Journal of Food Protection 49, 696705.
Gutteridge, JMC & Halliwell, B (1994) Antioxidants in Nutrition, Health and Disease. Oxford: Oxford University Press.
Gutteridge, JMC, Paterson, SK, Segal, AW & Halliwell, B (1981) Inhibition of lipid peroxidation by the iron-binding protein lactoferrin Biochemical Journal 56, 20792080.
Hambraeus, L, Lönnerdal, B (1994) The physiological role of lactoferrin Proceedings of the IDF Seminar, Indigenous Antimicrobial Agent of Milk. 97107.
Hicks, CL (1980) Occurrence and consequence of superoxide dismutase in milk products: a review Journal of Dairy Science 63, 11991204.
Hicks, CL, Bucy, J & Stofer, W (1979) Heat inactivation of superoxide dismutase in bovine milk Journal of Dairy Science 62, 529532.
Hill, RD (1975) Superoxide dismutase activity in bovine milk Australian Journal of Dairy Technology 30, 2628.
Hidiroglou, M (1989) Mammary transfer of vitamin E in dairy cows Journal of Dairy Science 72, 10671071.
Hirvi, Y & Griffiths, MW (1998) Milk catalase activity as an indicator of thermization treatments used in the manufacture of cheddar cheese Journal of Dairy Science 81, 338345.
Hirvi, Y, Griffiths, MW, McKellar, RC & Modler, HW (1996) Linear-transform and non-linear modelling of bovine milk catalase inactivation in a high-temperature short-time pasteurizer Food Research International 29, 8993.
Hoolbrook, JJ & Hicks, CL (1978) Variation of superoxide dismutase in bovine milk Journal of Dairy Science 61, 10721077.
Hojo, Y (1982) Selenium concentration and glutathione peroxidase activity in cows milk Biological Trace Element Research 4, 233239.
Hojo, Y (1986) Sequential study on glutathione peroxidase and selenium contents of human milk Science of the Total Environment 52, 8391.
Ito, O & Akuzawa, R (1983) Purification, crystallisation and properties of bovine milk catalase Journal of Dairy Science 66, 967973.
Ito, O & Akuzawa, R (1983) Isozymes of bovine milk catalase Journal of Dairy Science 66, 24682473.
Ito, O, Akuzawa, R & Kamata, S (1984) Immunochemical differences between two types catalase from cows milk cream Japanese Journal of Zootechnical Science 55, 722727.
Jensen, RG (1995) Fat-soluble vitamins in bovine milk. In Handbook of Milk Composition, pp. 718725 [Jensen, RG, editors]. San Diego: Academic Press.
Jensen, SK & Nielsen, KN (1996) Tocopherols, retinol, β-carotene and fatty acids in fat globule membrane and fat globule core in cow's milk Journal of Dairy Research 63, 565574.
Kankare, V & Antila, V (1982) The effect of xanthine oxidase and superoxide dismutase as well as cell counts on the oxidation of fat in bovine milk Finnish Journal of Dairy Science 2, 3240.
Khachik, F, Spangler, CJ, Smith, JC, Canfield, LM, Steck, A & Pfander, H (1997) Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum Analytical Chemistry 69, 18731881.
Kitchen, BJ, Taylor, GC & White, IC (1970) Milk enzymes – their distribution and activity Journal of Dairy Research 37, 279288.
Kiyosawa, I, Matuyama, J, Nyui, S & Yoshida, K (1993) Cu, Zn- and Mn- superoxide dismutase concentration in human colostrum and mature milk Bioscience, Biotechnology and Biochemistry 57, 676677.
Korhonen, H & Korpela, R (1994) The effects of dairy processes on the components and nutritional value of milk Scandinavian Journal of Nutrition 38, 166172.
Korpela, R, Ahotupa, M, Korhonen, H &, Syväoja, E-L (1995) Antioxidant properties of cow's milk. In Proceedings of the NJF/NMR Seminar no. 252, pp. 157159, Turku, Finland.
Korycka-Dahl, M, Richardson, T & Hicks, CL (1979) Superoxide dismutase activity in bovine milk serum Journal of Food Protection 42, 867871.
Ladenstein, R, Epp, O, Bartels, K, Jones, A, Huber, R & Wendel, A (1979) Structural analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 Å resolution Journal of Molecular Biology 134, 199218.
Martín-Alonso, J-M, Ghosh, S, Coca-Prados, M (1993) Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye Journal of Biochemistry 114, 284291.
Mills, GC (1957) Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown Journal of Biological Chemistry 229, 189197.
Nicholson, JWG, St-Laurent, A-M (1991) Effect of forage type and supplemental dietary vitamin E on milk oxidative stability Canadian Journal of Animal Science 71, 135143.
Nicholson, JW, St-Laurent, A-M, McQueen, RE & Charmley, E (1991) The effect feeding organically bound selenium and α-tocopherol to dairy cows on susceptibility of milk to oxidation Canadian Journal of Animal Science 71, 11811186.
Ollilainen, V, Heinonen, M, Linkola, E, Varo, P & Koivistoinen, P (1989) Carotenoids and retinoids in Finnish foods: dairy products and eggs Journal of Dairy Science 72, 22572265.
Paglia, DE & Valentine, WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase Journal of Laboratory and Clinical Medicine 70, 158169.
Pizzoferrato, L (1992) Examples of direct and indirect effects of technological treatments on ascorbic acid, folate and thiamine Food Chemistry 44, 4952.
Read, RB, Reyes, AL, Bradshaw, JG & Peeler, JT (1969) Evaluation of seven procedures for detection of abnormal milk due to mastitis Journal of Dairy Science 52, 13591367.
Ren, B, Huang, W, Åkesson, B & Ladenstein, R (1997) The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 Å resolution Journal of Molecular Biology 268, 869885.
Renner, E, Schaafsma, G, Scott, KJ (1989) Micronutrients in milk. In Micronutrients in Milk and Milk-based Food Products, pp. 170 [Renner, E, editors]. London: Elsevier Science Publishers.
Robinson, DS (1991) Peroxidases and catalases in foods. In Oxidative Enzymes in Foods [Robinson, DS and Eskin, NAM, editors]. London: Elsevier Science Publishers Ltd.
Rosenthal, I, Rosen, B & Bernstein, S (1993) Effect of milk fortification with ascorbic acid and iron Milchwissenschaft 48, 676679.
Rotilio, G, Calabrese, L, Bossa, F, Barra, D, Finazzi, Agró, A, and & Mondovi, B (1972) Properties of the apoprotein and role for copper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase Biochemistry 11, 21822192.
Ruas-Madiedo, P, Bascarán, V, Braña, AF, Bada-Gancedo, JC, de los Reyes-Gavilán, CG (1998) Influence of carbon dioxide addition to raw milk on microbial levels and some fat-soluble vitamin contents of raw and pasteurized milk Journal of Agricultural and Food Chemistry 46, 15521555.
Schweigert, FJ & Eisele, W (1990) Parenteral beta-carotene administration to cows: effect on plasma levels, lipoprotein distribution and secretion in the milk Zeitschrift für Ernährungswissenschaft 29, 184191.
Shinmoto, H, Dosako, S & Nakajima, I (1992) Anti-oxidant activity of bovine lactoferrin on iron/ascorbate induced lipid peroxidation Bioscience, Biotechnology and Biochemistry 56, 20792080.
Shonbaum, GR, Chance, B & and, PDBoyer (1976) Catalase The Enzymes vol. XIII, 363408.
Sies, H, Sharov, V, Klotz, L-O & Briviba, K (1997) Glutathione peroxidase protects against peroxynitrite-mediated oxidations Journal of Biological Chemistry 272, 2781227817.
St-Laurent, A-M, Hidiroglou, M, Snoddon, M & Nicholson, JWG (1990) Effect of α-tocopherol supplementation to dairy cows on milk and plasma α-tocopherol concentrations and on spontaneous oxidized flavor in milk Canadian Journal of Animal Science 70, 561570.
Takahashi, K, Avissar, N, Whitin, J & Cohen, HJ (1987) Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from known cellular enzyme Archives of Biochemistry and Biophysics 256, 677686.
Vahcic, N, Palic, A & Ritz, M (1992) Mathematical evaluation of relationships between copper, iron, ascorbic acid and redox potential of milk Milchwissenschaft 47, 228230.
Vidal-Valverde, C, Ruiz, R & Medrano, A (1993) Effects of frozen and other storage conditions on α-tocopherol content of cow milk Journal of Dairy Science 76, 15201525.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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