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Antiretroviral therapy with or without protease inhibitors impairs postprandial TAG hydrolysis in HIV-infected men

Abstract

Mechanisms underlying the lipodystrophy syndrome associated with antiretroviral therapy (ART) for HIV infection are not completely understood. We investigated the effect of ART on blood lipid concentrations in the fasting state and after consumption of a meal containing [1-13C]palmitic acid in HIV-positive men receiving nucleoside reverse transcriptase inhibitors (NRTI, n 7), NRTI combined with protease inhibitors (PI; NRTIPI, n 6), in HIV-positive but therapy-naïve men (noART, n 5) and in HIV-seronegative men (controls, n 6). HIV-positive subjects had higher fasting TAG concentrations and resting energy expenditure than controls. Subjects receiving NRTIPI therapy had higher fasting NEFA concentrations than the other groups. There were no significant differences in postprandial lipid metabolism between noART subjects and controls. NRTI therapy impaired hydrolysis of meal-derived TAG, most evidently when combined with PI (the NRTIPI group). Accumulation of 13C-label in the NEFA fraction was not different between groups. In the NRTIPI group, fasting and postprandial NEFA concentrations were significantly higher than other groups. Postprandial glucose and insulin responses in HIV-positive subjects did not differ from controls. These findings suggest that ART dyslipidaemia is associated with impaired postprandial TAG clearance, which is exacerbated by NRTIPI therapy. If dyslipidaemia is to be minimised in ART, the specific adverse effects of particular combinations during the fed state should be considered.

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Corresponding author
*Corresponding author: Dr Stephen A. Wootton, fax +44 2380 794945, email saw@southampton.ac.uk
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1M Egger , B Hirschel , P Francioli , (1997) Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study. Swiss HIV Cohort Study. BMJ 315, 11941199.

2FJ Palella Jr, KM Delaney , AC Moorman , (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. N Engl J Med 338, 853860.

3PP Sendi , HC Bucher , T Harr , (1999) Cost effectiveness of highly active antiretroviral therapy in HIV-infected patients. Swiss HIV Cohort Study. Aids 13, 11151122.

4A Carr , K Samaras , S Burton , (1998) A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 12, F51F58.

5A Carr , K Samaras , DJ Chisholm , (1998) Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 351, 18811883.

6JH Stein , MA Klein , JL Bellehumeur , (2001) Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. Circulation 104, 257262.

7UH Iloeje , Y Yuan , G L'Italien , (2005) Protease inhibitor exposure and increased risk of cardiovascular disease in HIV-infected patients. HIV Med 6, 3744.

8I Sudano , LE Spieker , G Noll , (2006) Cardiovascular disease in HIV infection. Am Heart J 151, 11471155.

9E Bernasconi , K Boubaker , C Junghans , (2002) Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs: The Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 31, 5055.

10A Carr , S Emery , M Law , (2003) An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet 361, 726735.

11RM Blümer , MG van Vonderen , J Sutinen , (2008) Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. AIDS 22, 227236.

12GM Behrens , AR Boerner , K Weber , (2002) Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy. J Clin Invest 110, 13191327.

13SD Fisher , TL Miller & SE Lipshultz (2006) Impact of HIV and highly active antiretroviral therapy on leukocyte adhesion molecules, arterial inflammation, dyslipidemia, and atherosclerosis. Atherosclerosis 185, 111.

14C Hadigan , S Borgonha , J Rabe , (2002) Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy. Metabolism 51, 5.

15DN Reeds , B Mittendorfer , BW Patterson , (2003) Alterations in lipid kinetics in men with HIV-dyslipidemia. Am J Physiol Endocrinol Metab 285, E490E497.

16A Balasubramanyam , RV Sekhar , F Jahoor , (2004) Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: A model of ‘systemic steatosis’. Curr Opin Lipidol 15, 5967.

17KN Frayn , SW Coppack , BA Fielding , (1995) Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv Enzyme Regul 35, 163178.

18K Evans , GC Burdge , SA Wootton , (2002) Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 51, 26842690.

19K Evans , GC Burdge , SA Wootton , (2007) Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia. Atherosclerosis 197, 164170.

21JH Stein , MA Merwood , JB Bellehumeur , (2005) Postprandial lipoprotein changes in patients taking antiretroviral therapy for HIV infection. Arterioscler Thromb Vasc Biol 25, 399405.

22JP van Wijk , MC Cabezas , EJ de Koning , (2005) In vivo evidence of impaired peripheral fatty acid trapping in patients with human immunodeficiency virus-associated lipodystrophy. J Clin Endocrinol Metab 90, 35753582.

23JL Murphy , A Jones , S Brookes , (1995) The gastrointestinal handling and metabolism of [1-13C]palmitic acid in healthy women. Lipids 30, 291298.

27GC Burdge , AE Jones , SM Frye , (2003) Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men. Eur J Clin Nutr 57, 15361544.

28C Grunfeld , M Pang , W Doerrler , (1992) Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 74, 10451052.

30RV Sekhar , F Jahoor , AC White , (2002) Metabolic basis of HIV-lipodystrophy syndrome. Am J Physiol Endocrinol Metab 283, E332E337.

31DP Kotler , G Ionescu , JA Johnson , (2003) Studies of adipose tissue metabolism in human immunodeficiency virus-associated lipodystrophy. Clin Infect Dis 37, Suppl. 2, S47S51.

32L Baril , I Beucler , MA Valantin , (2001) Low lipolytic enzyme activity in patients with severe hypertriglyceridemia on highly active antiretroviral therapy. AIDS 15, 415417.

33W Khovidhunkit , MS Kim , RA Memon , (2004) Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 45, 11691196.

34MA den Boer , JF Berbée , P Reiss , (2006) Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue. Arterioscler Thromb Vasc Biol 26, 124129.

35PJ Randle (1998) Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14, 21.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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