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Application of NMR-based metabonomics suggests a relationship between betaine absorption and elevated creatine plasma concentrations in catheterised sows

  • Christian Clement Yde (a1) (a2), Johan A. Westerhuis (a3), Hanne Christine Bertram (a2) and Knud Erik Bach Knudsen (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114511004909
  • Published online: 28 September 2011
Abstract

The objective of the present explorative study was to determine the absorption dynamics when feeding diets varying in types and levels of dietary fibre in a catheterised animal model. A total of six sows were fed a diet low in fibre (LF), a diet high in soluble fibre and a diet high in insoluble fibre in a repeated 3 × 3 cross-over design. Plasma samples were collected from the mesenteric artery and the portal vein to determine different absorption phases by 1H NMR spectroscopy-based metabonomics. Time profiles were determined for plasma levels of specific metabolites and for the absorption of these metabolites from the small intestine. The LF diet resulted in a higher betaine concentration in the blood than the two high-fibre diets (P = 0·008). This leads to higher plasma concentrations of methionine (P = 0·0028) and creatine (P = 0·020) of endogenous origin. In conclusion, the use of NMR spectroscopy for measuring nutrient uptake in the present study elucidated the relationship between betaine uptake and elevated creatine plasma concentrations.

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Corresponding author
*Corresponding author: Dr C. C. Yde, email christianc.yde@agrsci.dk
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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