Skip to main content Accessibility help
×
Home

Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails

  • Kazim Sahin (a1), Cemal Orhan (a1), Mehmet Tuzcu (a2), Maria H. Borawska (a3), Jakub Jabłonski (a4), Osman Guler (a5), Nurhan Sahin (a1) and Armagan Hayirli (a6)...

Abstract

To evaluate the action mode of Berberis vulgaris root extract in the alleviation of oxidative stress, female Japanese quails (n 180, aged 5 weeks) were reared, either at 22°C for 24 h/d (thermoneutral, TN) or 34°C for 8 h/d (heat stress, HS), and fed one of three diets: diets containing 0, 100 or 200 mg of B. vulgaris root extract per kg for 12 weeks. Exposure to HS depressed feed intake by 8·5 % and egg production by 12·1 %, increased hepatic malondialdehyde (MDA) level by 98·0 % and decreased hepatic superoxide dismutase, catalase and glutathione peroxidase activities by 23·5, 35·4 and 55·7 %, respectively (P< 0·001 for all). There were also aggravations in expressions of hepatic NF-κB and heat-shock protein 70 (HSP70) by 42 and 43 %, respectively and suppressions in expressions of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and haeme-oxygenase 1 (HO-1) by 57 and 61 %, respectively, in heat-stressed quails (P< 0·001 for all). As supplemental B. vulgaris extract increased, there were linear increases in performance parameters, activities of antioxidant enzymes and hepatic Nrf2 and HO-1 expressions (P< 0·001 for all) and linear decreases in hepatic MDA level and NF-κB and HSP70 expressions at a greater extent in quails reared under TN condition and those reared under HS condition. In conclusion, dietary supplementation of B. vulgaris root extract to quails reduces the detrimental effects of oxidative stress and lipid peroxidation resulting from HS via activating the host defence system at the cellular level.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Professor K. Sahin, fax +90 424 238 8173, email nsahinkm@yahoo.com

References

Hide All
1Bogin, E, Avidar, Y, Pech-Waffenschmidt, V, et al. (1996) The relationship between heat stress, survivability and blood composition of the domestic chicken. Eur J Clin Chem Biochem 34, 463469.
2Yalcin, S, Ozkan, S, Turkmut, L, et al. (2001) Responses to heat stress in commercial and local broiler stocks. 1. Performance traits. Br Poult Sci 42, 149152.
3Sandercock, DA, Hunter, RR, Nute, GR, et al. (2001) Acute heat stress-induced alterations in blood acid–base status and skeletal muscle membrane integrity in broiler chickens at two ages: implications for meat quality. Poult Sci 80, 418425.
4Halliwell, BE & Gutteridge, JMC (1989) Lipid peroxidation: a radical chain reaction. In Free Radicals in Biology and Medicine, 2nd ed., pp. 188218. New York, NY: Oxford University Press.
5Sahin, K & Kucuk, O (2003) Heat stress and dietary vitamin supplementation of poultry diets. Nutr Abstr Rev Ser B Livest Feeds Feed 73, 4150.
6Sahin, K, Sahin, N, Kucuk, O, et al. (2009) Role of dietary zinc in heat-stressed poultry: a review. Poult Sci 88, 21762183.
7Meng, Q, Velalar, CN & Ruan, R (2008) Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast. Free Radic Biol Med 44, 10321041.
8Puthpongsiriporn, U, Scheideler, SE, Sell, JL, et al. (2001) Effects of vitamin E and C supplementation on performance, in vitro lymphocyte proliferation, and antioxidant status of laying hens during heat stress. Poult Sci 80, 11901200.
9Franchini, A, Sirri, F, Tallarico, N, et al. (2002) Oxidative stability and sensory and functional properties of eggs from laying hens fed supranutritional doses of vitamins E and C. Poult Sci 81, 17441750.
10Sahin, N, Orhan, C, Tuzcu, M, et al. (2008) The effects of tomato powder supplementation on performance and lipid peroxidation in quail. Poult Sci 87, 276283.
11Tuzcu, M, Sahin, N, Karatepe, M, et al. (2008) Epigallocatechin-3-gallate supplementation can improve antioxidant status in stressed quail. Br Poult Sci 49, 643648.
12Imanshahidi, M & Hosseinzadeh, H (2008) Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 22, 9991012.
13Zovko-Koncić, M, Kremer, D, Karlović, K, et al. (2010) Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. Food Chem Toxicol 48, 21762180.
14Ivanovska, N & Philipov, S (1996) Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 18, 553561.
15Souto, AL, Tavares, JF, da Silva, MS, et al. (2011) Anti-inflammatory activity of alkaloids: an update from 2000 to 2010. Molecules 16, 85158534.
16Kosalec, I, Gregurek, B, Kremer, D, et al. (2009) Croatian barberry (Berberis croatica Horvat): a new source of berberine—analysis and antimicrobial activity. World J Microbiol Biotechnol 25, 145150.
17Bashir, S, Gilani, AH, Siddiqui, AA, et al. (2010) Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats. Phytother Res 24, 12501255.
18Bhutada, P, Mundhada, Y, Bansod, K, et al. (2010) Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav 18, 207210.
19Fatehi, M, Saleh, TM, Fatehi-Hassanabad, Z, et al. (2005) A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol 102, 4652.
20Blumenthal, M, editor. (1998) The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston: Integrative Medicine Communications.
21Arayne, MS, Sultana, N, Bahadur, SS, et al. (2007) The berberis story: Berberis vulgaris in therapeutics. Pak J Pharm Sci 20, 8392.
22Vaquerizas, JM, Kummerfeld, SK, Teichmann, SA, et al. (2009) A census of human transcription factors: function, expression and evolution. Nat Rev Genet 10, 252263.
23Gilmore, TD (2006) Introduction to NF-κB: players, pathways, perspectives. Oncogene 25, 66806684.
24Nelson, DE, Ihekwaba, AE, Elliott, M, et al. (2004) Oscillations in NF-κB signaling control the dynamics of gene expression. Science 306, 704708.
25Mahmoud, KZ, Edens, FW, Eisen, EJ, et al. (2003) Effect of ascorbic acid and acute heat exposure on heat shock protein 70 expression by young white Leghorn chickens. Comp Biochem Physiol C Toxicol Pharmacol 136, 329335.
26Figueiredo, D, Gertler, A, Cabello, G, et al. (2007) Leptin downregulates heat shock protein-70 (HSP-70) gene expression in chicken liver and hypothalamus. Cell Tissue Res 329, 91101.
27Murakami, H, Pain, D & Blobel, G (1988) 70-kD Heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria. J Cell Biol 107, 20512057.
28Wang, S & Edens, FW (1998) Heat conditioning induces heat shock proteins in broiler chickens and Turkey poults. Poult Sci 77, 16361645.
29Itoh, K, Wakabayashi, N, Katoh, Y, et al. (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13, 7686.
30Yamamoto, T, Suzuki, T, Kobayashi, A, et al. (2008) Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol 28, 27582770.
31Itoh, K, Chiba, T, Takahashi, S, et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236, 313322.
32Sahin, K, Orhan, C, Tuzcu, M, et al. (2010) Epigallocatechin-3-gallate prevents lipid peroxidation and enhances antioxidant defense system via modulating hepatic nuclear transcription factors in heat-stressed quails. Poult Sci 89, 22512258.
33Kermanshahi, H & Riasi, A (2006) Effect of dietary dried Berberis vulgaris fruit and enzyme on some blood parameters of laying hens fed wheat–soybean based diets. Int J Poult Sci 5, 8992.
34Farombi, EO, Shrotriya, S, Na, HK, et al. (2008) Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol 46, 12791287.
35Jung, KH, Hong, SW, Zheng, HM, et al. (2009) Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J Pineal Res 47, 173183.
36Velázquez, E, Tournier, HA & Mordujovich de Buschiazzo, P (2003) Antioxidant activity of Paraguayan plants extracts. Fitoterapia 74, 9197.
37Motalleb, G, Hanachi, P, Kua, SH, et al. (2005) Evaluation of phenolic content and total antioxidant activity in Berberis vulgaris fruit extract. J Biol Sci 5, 648653.
38Djeridane, A, Yousfi, M, Nadjemi, B, et al. (2006) Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem 97, 654660.
39Barim, O & Karatepe, M (2010) The effects of pollution on the vitamins A, E, C, beta carotene contents and oxidative stress of the freshwater crayfish, Astacus leptodactylus. Ecotoxicol Environ Saf 73, 138142.
40Spitz, DR & Oberley, LW (1989) An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 179, 818.
41Cohen, G, Dembiec, D & Marcus, J (1970) Measurement of catalase activity in tissue extracts. Anal Biochem 34, 3038.
42Lawrence, RA & Burk, RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71, 952958.
43AOAC (1990) Official Methods of Analysis, 15th ed.Washington, DC: Association of Official Analytical Chemists.
44Jurgens, MH (1996) Animal Feeding and Nutrition, 8th ed.Dubuque, IA: Kendall/Hunt Publishing Company.
45SAS (2002) SAS User's Guide: Statistics (version 9). Cary, NC: Statistical Analysis System Institute, Inc.
46Rajaian, H, Jalaee, J & Aghajani, A (2006) Berberis vulgaris as growth promoter in broiler chickens. Int J Poult Sci 5, 395397.
47Mujahid, A, Pumford, NR, Bottje, W, et al. (2007) Mitochondrial oxidative damage in chicken skeletal muscle induced by acute heat stress. Jpn Poult Sci 44, 439445.
48Tan, GY, Yang, L & Fu, YQ (2010) Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens. Poult Sci 89, 115122.
49Tomosaka, H, Chin, YW, Salim, AA, et al. (2008) Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry). Phytother Res 22, 979981.
50Hanachi, P & Golkho, SH (2009) Using HPLC to determination the composition and antioxidant activity of Berberis vulgaris. Eur J Sci Res 29, 4754.
51Hanachi, P, Kua, SH, Asmah, R, et al. (2006) Cytotoxic effect of Berberis vulgaris fruit extract on the proliferation of human liver cancer cell line (HepG2) and its antioxidant properties. Int J Cancer Res 2, 19.
52Domitrović, R, Jakovac, H & Blagojević, G (2011) Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. Toxicology 280, 3343.
53Nair, S, Li, W & Kong, AN (2007) Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells. Acta Pharmacol Sin 28, 459472.
54Na, HK & Surh, YJ (2008) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol 46, 12711278.
55Surh, YJ, Kundu, JK, Na, HK, et al. (2005) Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J Nutr 135, 29933001.
56Rahman, I, Biswas, SK & Kirkham, PA (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72, 14391452.
57Nguyen, T, Nioi, P & Pickett, CB (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284, 13291–12295.
58Hsiang, CY, Wu, SL, Cheng, SE, et al. (2005) Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-α production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 12, 791801.
59Liu, W, Zhang, X, Liu, P, et al. (2010) Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury. Eur J Pharmacol 638, 150155.
60Chen, JH, Huang, SM, Tan, TW, et al. (2012) Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes. Int Immunopharmacol 12, 94100.
61Sahin, N, Tuzcu, M, Orhan, C, et al. (2009) The effects of vitamin C and E supplementation on heat shock protein 70 response of ovary and brain in heat-stressed quail. Br Poult Sci 50, 259265.
62Mahmoud, KZ & Edens, FW (2003) Influence of selenium sources on age-related and mild heat stress-related changes of blood and liver glutathione redox cycle in broiler chickens (Gallus domesticus). Comp Biochem Physiol B Biochem Mol Biol 136, 921934.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed