Skip to main content
×
Home
    • Aa
    • Aa

Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects

  • Ditte A. Hobbs (a1) (a2), Nedi Kaffa (a1) (a2), Trevor W. George (a3), Lisa Methven (a1) and Julie A. Lovegrove (a1) (a2)...
Abstract

A number of vegetables have a high nitrate content which after ingestion can be reduced to nitrite by oral bacteria, and further to vasoprotective NO endogenously. In the present study, two separate randomly controlled, single-blind, cross-over, postprandial studies were performed in normotensive volunteers. Ambulatory blood pressure (BP) was measured over a 24 h period following consumption of either four doses of beetroot juice (BJ), 0, 100, 250 and 500 g (n 18), or three bread products, control bread (0 g beetroot), red beetroot- and white beetroot-enriched breads (n 14). Total urinary nitrate/nitrite (NOx) was measured at baseline, and at 2, 4 and 24 h post-ingestion. BJ consumption significantly, and in a near dose-dependent manner, lowered systolic BP (SBP, P < 0·01) and diastolic BP (DBP, P < 0·001) over a period of 24 h, compared with water control. Furthermore, bread products enriched with 100 g red or white beetroot lowered SBP and DBP over a period of 24 h (red beetroot-enriched bread, P <0·05), with no statistical differences between the varieties. Total urinary NOx significantly increased following the consumption of 100 g (P < 0·01), 250 g (P <0·001) and 500 g BJ (P <0·001) and after red beetroot-enriched bread ingestion (P <0·05), but did not reach significance for white beetroot-enriched bread compared with the no-beetroot condition. These studies demonstrated significant hypotensive effects of a low dose (100 g) of beetroot which was unaffected by processing or the presence of betacyanins. These data strengthen the evidence for cardioprotective BP-lowering effects of dietary nitrate-rich vegetables.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor J. A. Lovegrove, email j.a.lovegrove@reading.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 CMM Lawes , SV Hoorn & A Rodgers (2008) Global burden of blood-pressure-related disease, 2001. Lancet 371, 15131518.

3 S MacMahon , R Peto , R Collins , et al. (1990) Blood pressure, stroke, and coronary heart disease: part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335, 765774.

4 RS Vasan , MG Larson , EP Leip , et al. (2001) Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 345, 12911297.

5 W Wang , ET Lee , RR Fabsitz , et al. (2006) A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: the strong heart study. Hypertension 47, 403409.

6 R Collins , R Peto , S MacMahon , et al. (1990) Blood pressure, stroke, and coronary heart disease: part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335, 827838.

7 S Julius , SD Nesbitt , BM Egan , et al. (2006) Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med 354, 16851697.

8 LJ Appel , TJ Moore , E Obarzanek , et al. (1997) A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 336, 11171124.

9 X Zhang , X-O Shu , Y-B Xiang , et al. (2011) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality. Am J Clin Nutr 94, 240246.

10 DP Vivekananthan , MS Penn , SK Sapp , et al. (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361, 20172023.

12 KJ Joshipura , A Ascherio , JE Manson , et al. (1999) Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282, 12331239.

13 KJ Joshipura , FB Hu , JE Manson , et al. (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 11061114.

15 FJ Larsen , B Ekblom , K Sahlin , et al. (2006) Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med 355, 27922793.

16 AJ Webb , N Patel , S Loukogeorgakis , et al. (2008) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 51, 784790.

17 H Li , H Cui , TK Kundu , et al. (2008) Nitric oxide production from nitrite occurs primarily in tissues not in the blood. J Biol Chem 283, 1785517863.

18 AJ Webb , AB Milsom , KS Rathod , et al. (2008) Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res 103, 957964.

19 JO Lundberg , E Weitzberg & MT Gladwin (2008) The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7, 156167.

20 V Kapil , AB Milsom , M Okorie , et al. (2010) Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56, 274281.

22 M Wettasinghe , B Bolling , L Plhak , et al. (2002) Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. J Agric Food Chem 50, 67046709.

23 J Kanner , S Harel & R Granit (2001) Betalains a new class of dietary cationized antioxidants. J Agric Food Chem 49, 51785185.

25 JO Lundberg & E Weitzberg (2005) NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol 25, 915922.

26 B Bartholomew & MJ Hill (1984) The pharmacology of dietary nitrate and the origin of urinary nitrate. Food Chem Toxicol 22, 789795.

27 NK Cortas & NW Wakid (1991) Pharmacokinetic aspects of inorganic nitrate ingestion in man. Pharmacol Toxicol 68, 192195.

28 AS Pannala , AR Mani , JPE Spencer , et al. (2003) The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Bio Med 34, 576584.

29 JO Lundberg , E Weitzberg , JM Lundberg , et al. (1994) Intragastric nitric oxide production in humans: measurements in expelled air. Gut 35, 15431546.

30 T Sobko , CI Reinders , EA Jansson , et al. (2005) Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite. Nitric Oxide 13, 272278.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 108
Total number of PDF views: 570 *
Loading metrics...

Abstract views

Total abstract views: 1576 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st September 2017. This data will be updated every 24 hours.