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Carbohydrate intake improves cognitive performance of stress-prone individuals under controllable laboratory stress

  • C. R. Markus (a1), G. Panhuysen (a1), L. M. Jonkman (a1) and M. Bachman (a1)

Cognitive performance has been found to decline after exposure to stress, particularly in stress-prone subjects. The present study investigated whether a carbohydrate-rich, protein-poor (CR/PP) diet, which may enhance cerebral serotonin function in stress-prone subjects due to increases in the available tryptophan, improves the performance of stress-prone subjects after exposure to acute laboratory stress. Twenty-two high-stress-prone (HS) subjects and twenty-one low-stress-prone (LS) subjects aged between 19 and 26 years performed a memory scanning task after controllable and uncontrollable stress, following either a CR/PP diet or a protein-rich, carbohydrate-poor (PR/CP) isoenergetic diet. Uncontrollable stress reduced feelings of control (F(1,38) 9·30; P = 0·004), whereas pulse rate and skin conductance increased after both stress tasks (F(1,38) 78·34; P = 0·0005 and F(1,37) 83·16; P = 0·0004). Diet, stress-proneness and stress-controllability interacted (F(1,36) 9·46; P = 0·004) in such a way that performance in HS subjects was better with the CR/PP diet than with the PR/CP diet, but only after controllable stress. As the CR/PP diet has been found to increase the plasma tryptophan: large neutral amino acids ratio, indicating an increased availability of cerebral tryptophan and, thus, higher serotonin levels, it appears that there may be an increased availability of brain serotonin in HS subjects after controllable laboratory stress.

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Corresponding author
*Corresponding author: Dr Rob Markus, present address TNO Nutrition and Food Research Institute, Division of Target Organ Toxicology, Utrechtseweg 48, PO Box 360, 3700 AJ Zeist, The Netherlands, fax +31 30 6960264, email
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Adell A, Garcia-Marquez C, Armario A & Gelpi E (1988) Chronic stress increases serotonin and noradrenaline in rat brain and sensitizes their responses to a further acute stress. Journal of Neurochemistry 50, 16781681.
Altman HJ & Normile HJ (1988) What is the nature of the role of serotonergic nervous system in learning and memory: prospects for development of an effective treatment strategy for senile dementia. Neurobiology of Aging 9, 627638.
Anisman H & Zacharko RM (1991) Multiple neurochemical and behavioral consequences of stressors: implications for depression. In Psychopharmacology of Anxiolytics and Antidepressants, pp. 5782 [File SE, editor]. New York, NY: Pergamon.
Bellisle F, Blundell JE, Dye L, Fantino M, Fletcher RJ, Lambert J, Roberfroid M, Specter S, Westenhöver J & Westerterp-Plantenga MS (1998) Functional food science and behaviour and psychological functions. British Journal of Nutrition 80, Suppl. 1, S173S193.
Bolger N & Schilling EA (1991) Personality and the problems of everyday life: the role of neuroticism in exposure and reactivity to daily stressors. Journal of Personality 59, 355386.
Brand N & Houx PJ (1992) MINDS: Towards a computerized test battery for health psychological and neuropsychological assessment. Behavioural Research Methods, Instrumentation and Computers 24, 385389.
Bremner JD, Southwick SM, Brett E, Fontana A, Rosenheck R & Charney DS (1992) Dissociation and posttraumatic stress disorder in Vietnam combat veterans. American Journal of Psychiatry 149, 328332.
Cancela LM & Molina VA (1990) Reduced apomorphine-induced sedation following chronic stress. European Journal of Pharmacology 134, 117119.
Christensen L & Redig C (1993) Effect of meal composition on mood. Behavioral Neuroscience 107, 346353.
Christensen L, White B & Krietsch K (1985) Failure to identify an expectancy effect in nutritional research. Nutrition and Behavior 2, 149159.
Cohen S, Evans G, Krantz G & Stokals D (1980) Physiological, motivational, and cognitive effects of noise in children. American Psychologist 35, 231245.
Curzon G (1985) Effects of food intake on brain transmitter amine precursors and amine synthesis. In Psychopharmacology and Food, pp. 5970 [Sandler M and Silverstone T, editors]. Oxford: Oxford University Press.
Deakin JWF (1991) Depression and 5-HT. International Clinical Psychopharmacology 3, 2328.
Deakin JWF & Graeff FG (1991) 5-HT and mechanisms of defence. Journal of Psychopharmacology 5, 305315.
Deary L & Matthews G (1993) Personality traits are alive and well. Psychologist 6, 299311.
Delbende C, Delarue C, Lefebvre H, Tranchand-Bunel D, Szafarczyk A, Mocaer E, Kamoun A, Jegou S & Vaudry H (1992) Glucocorticoids, transmitters and stress. British Journal of Psychiatry 160, Suppl. 15, 2434.
Eysenck MW (1982) Attention and Arousal. Berlin: Springer-Verlag.
Fernstrom JD, Larin F & Wurtman RJ (1973) Correlations between brain tryptophan and plasma neutral amino acids levels following food consumption in rats. Life Sciences 13, 517.
Fernstrom JD & Wurtman RJ (1971 a) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173, 149152.
Fernstrom JD & Wurtman RJ (1971 b) Brain serotonin content: increase following ingestion of carbohydrate diet. Science 174, 10231025.
Fernstrom JD & Wurtman RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178, 414416.
Gallagher DJ (1990) Extraversion, neuroticism and appraisal of stressful academic events. Personality and Individual Differences 11, 10531058.
Hockey GR & Hamilton P (1983) The cognitive patterning of stress states. In Stress and Fatigue in Human Performance, pp. 331363 [Hockey GRJ, editor]. New York, NY: John Wiley & Sons.
Joseph MH & Kennett GA (1983) Stress-induced release of 5-HT in the hippocampus and its dependence on increased tryptophan availability: an in vivo electrochemical study. Brain Research 270, 251257.
Kanarek RB & Swinney D (1990) Effects of food snacks on cognitive performance in male college students. Appetite 14, 1527.
Kennett GA, Dickinson SL & Curzon G (1985) Enhancement of some 5-HT-dependent behavioral responses following repeated immobilisation in rats. Brain Research 330, 253263.
Kramer TH, Buckhout R, Fox P, Widman E & Tusche B (1991) Effects of stress on recall. Applied Cognitive Psychology 5, 483488.
Lieberman HR, Caballero B & Finer N (1986) The composition of lunch determines afternoon plasma tryptophan ratios in humans. Journal of Neural Transmission 65, 211217.
Lloyd HM, Rogers PJ & Hedderley DI (1996) Acute effects on mood and cognitive performance of breakfast differing in fat and carbohydrate content. Appetite 27, 151164.
Loeb M (1986) Noise and Human Efficiency. Chichester: John Wiley & Sons.
Luteijn F & Bouman TK (1988) The concepts of depression, anxiety and neuroticism in questionnaires. European Journal of Personality 2, 113120.
Luteijn F, Starren J & van Dijk H (1975) Nederlandse Persoonlijkheids Vragenlijst (Dutch Personality Inventory). The Netherlands: Swets & Zeitlinger.
Mandler G (1984) Mind and Body; Psychology of Emotion and Stress. New York, NY: Norton.
Markus CR, Panhuysen G, Tuiten A, Koppeschaar H, Fekkes D & Peters M (1998) Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task?. Appetite 31, 4965.
Marmar CR, Weiss DS, Schlenger WE, Fairbank JA, Jordan BK, Kulka RA & Hough RL (1994) Peritraumatic dissociation and posttraumatic stress in male Vietnam theater veterans. American Journal of Psychiatry 151, 902908.
Peters ML, Godaert GLR, Ballieux RE, van Vliet M, Willemsen JJ, Sweep CGJ & Heijnen CJ (1998) Cardiovascular and catecholamine response to experimental stress: effects of mental effort and controllability. Psychoneuroendocrinology 23, 117.
Pijl H, Koppeschaar HPF, Cohen AF, Iestra JA, Schoenmaker HC, Frölich M, Onkenhout W & Meinders AE (1993) Evidence for brain serotonin-mediated control of carbohydrate consumption in normal weight and obese humans. International Journal of Obesity 17, 513520.
Rosenthal NE, Genhart MJ, Caballero B, Jacobsen FM, Skwerer RG, Coursey RD, Rogers S & Spring B (1989) Psychobiological effects of carbohydrate- and protein-rich meals in patients with seasonal affective disorder and normal controls. Biological Psychiatry 25, 10291040.
Smith A (1990) Stress and information processing. In Stress and Medical Procedures, pp. 5879 [Johnston M and Wallace L, editors]. Oxford: Oxford University Press.
Sorg BA & Whitney P (1992) The effect of trait anxiety and situational stress on working memory capacity. Journal of Research in Personality 26, 235241.
Spoont MR (1992) Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychological Bulletin 112, 330350.
Spring B, Chiodo J & Bowen DJ (1987) Carbohydrates, tryptophan and behavior: a methodological review. Psychological Bulletin 102, 234256.
Spring B, Maller O, Wurtman J, Digman L & Gozolino L (1982/1983) Effects of protein and carbohydrate meals on mood and performance: interactions with sex and age. Journal of Psychiatric Research 17, 155167.
Stanford SC (1993) Monoamines in response and adaptation to stress. In Stress, From Synapse to Syndrome, pp. 2430 [Stanford SC and Salmon P, editors]. London: Academic Press.
Stelmack RM, Wieland LD, Wall MU & Plouffe L (1984) Personality and the effects of stress on recognition memory. Journal of Research in Personality 18, 164178.
Sternberg S (1969) Memory-scanning: mental processes revealed by reaction-time experiments. American Scientist 57, 421457.
Sternberg S (1975) Memory scanning: new findings and current controversies. Quarterly Journal of Experimental Psychology 27, 132.
Tuiten A, Panhuysen G, Koppeschaar H, Fekkes D, Pijl H, Frolich M, Krabbe P & Everaerd W (1995) Stress, serotonergic functioning, and mood in users of oral contraceptives. Psychoneuroendocrinology 20, 111.
Watson D & Clark LA (1984) Negative affectivity: the disposition to experience aversive emotional states. Psychological Bulletin 96, 465490.
Wells A & Matthews G (1994) Attention and Emotion: A Clinical Perspective. London: Lawrence Erlbaum Associates Publishers.
Wurtman RJ (1987) Nutrients affecting brain composition and behavior. Integrative Psychiatry 5, 226257.
Yokogoshi H & Wurtman RJ (1986) Meal composition and plasma amino acid ratios: effects of various proteins or carbohydrates, and of various protein concentrations. Metabolism 35, 837842.
Young SN (1991) Some effects of dietary components (amino acids, carbohydrate, folic acid) on brain serotonin synthesis, mood, and behaviour. Canadian Journal of Physiology and Pharmacology 69, 893903.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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