Hostname: page-component-5d84bcc8dc-wjd8b Total loading time: 0 Render date: 2026-08-15T21:36:24.151Z Has data issue: false hasContentIssue false
  • English
  • Français
Accepted manuscript

Cetoleic acid rich fish oil increases plasma levels of eicosapentaenoic and docosapentaenoic acids in healthy volunteers: a double-blinded, randomised, controlled trial

Published online by Cambridge University Press:  30 July 2026

Kirsten B. Holven Open the ORCID record for Kirsten B. Holven [Opens in a new window] ,
Tuva B. Dahl ,
Pia Bålsrud ,
Jacob J. Christensen Open the ORCID record for Jacob J. Christensen [Opens in a new window] ,
Inger Ottestad ,
Amanda Rundblad ,
Bente Ruyter ,
Sverre Holm ,
Pål Aukrust  and
Ylva Schanke
...Show all authors
Kirsten B. Holven*
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway. National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Tuva B. Dahl
Affiliation:
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Pia Bålsrud
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
Jacob J. Christensen
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
Inger Ottestad
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway. Clinical Nutrition Outpatient Clinic, Section of Clinical Nutrition, Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway
Amanda Rundblad
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
Bente Ruyter
Affiliation:
Nofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, 1432 Ås, Norway
Sverre Holm
Affiliation:
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Pål Aukrust
Affiliation:
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ylva Schanke
Affiliation:
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Iselin Schjelle Holen
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway. National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Vibeke H. Telle-Hansen
Affiliation:
Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Norway.
Kjetil Retterstøl
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
Stine M. Ulven
Affiliation:
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046 Blindern, 0317, Oslo, Norway.
Bente Halvorsen
Affiliation:
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
*
Corresponding author: Kirsten Holven, Email: k.b.holven@medisin.uio.no
Rights & Permissions [Opens in a new window]

Accessibility of Accepted Manuscripts

Accepted Manuscripts are early, peer-reviewed versions that have not yet been copyedited, typeset, or formally published and may not meet all accessibility standards. A fully formatted accessible version will follow.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

Intake of fish and supplementation with n-3 polyunsaturated fatty acids (PUFA) are associated with reduced incidence of cardiovascular disease (CVD). Cetoleic acid promotes n-3 PUFA generation in salmon and human HepG2 cells, but data in humans are scarce. To explore the effect of cetoleic acid on n-3 PUFA levels, we performed a double-blinded randomised controlled trial in healthy adults (37 females and 12 males) for four weeks. The participants were randomised to consume either capsules with mackerel oil, naturally rich in cetoleic acid, or a control oil, both with a similar concentration of n-3 PUFA. Clinicaltrials.gov (NCT04841044). Supplements with mackerel oil resulted in higher plasma levels of the n-3 PUFAs 20:4n-3 (Eicosatetraenoic acid) and 20:5n-3 (Eicosapentaenoic acid) as compared with those receiving control oil. In addition, those who received the cetoleic-rich capsules had higher levels of 20:4n-3 in the RBC membrane and a decrease in expression of elongation of very long chain fatty acids protein 5 in peripheral blood mononuclear cells. We found no differences in lipid, glucose or C-reactive protein between the two treatment groups, consisting of healthy subjects. Our data suggests that supplementation with cetoleic-rich mackerel oil may result in increased levels of certain n-3 PUFAs. Further studies should include patients with or at risk for metabolic and CVD.

Keywords

Cetoleic acidpolyunsaturated fatty acidsEicosatetraenoic acideicosapentaenoic acid

Information

Type
Research Article
Information
British Journal of Nutrition , Accepted manuscript , pp. 1 - 28
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society