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Coconut fat and serum lipoproteins: effects of partial replacement with unsaturated fats

  • Shanthi Mendis (a1) (a2), U. Samarajeewa (a3) and R. O. Thattil (a3)
Abstract

The aim of the present study was to examine the effect of reducing saturated fat in the diet, or partly replacing it with unsaturated fat, on the serum lipoprotein profile of human subjects. The study had two intervention periods, 8 weeks (phase 1) and 52 weeks (phase 2). In phase 1, total fat was reduced from 31 to 25 % energy (polyunsaturated fatty acids (PUFA):saturated fatty acids (SFA) ratio increased from 0.2 to 0.4) by reducing the quantity of coconut fat (CF) in the diet from 17.8 to 9.3 % energy intake. In phase 2, subjects were randomised to groups A and B. In group A total fat was reduced from 25 to 20 % energy (PUFA:SFA ratio increased from 0.4 to 0.7) by reducing the quantity of CF in the diet from 9.3 to 4.7 % total energy intake. In group B, the saturated fat content in the diet was similar to group A. In addition a test fat (a mixture of soyabean oil and sesame oil, PUFA:monosaturated fatty acids ratio 2) contributed 3.3 % total energy intake and total fat contributed 24 % energy intake (PUFA:SFA ratio increased from 0.7 to 1.1). At the end of phase 1, there was a 7.7 % reduction in cholesterol (95 % CI -3.6, -12.2) and 10.8 % reduction in LDL (95 % CI -4.9, -16.5) and no significant change in HDL and triacylglycerol. At the end of phase 2, the reduction in cholesterol in both groups was only about 4 % (95 % CI -12, 3.2) partly due the concomitant rise in HDL. The reduction in LDL at 52 weeks was significantly higher in group B (group A mean reduction 11 %, 95 % CI -20.1, -2.0 and group B mean reduction 16.2 % 95 % CI -23.5, -8.9). In phase 2, triacylglycerol levels showed a mean reduction of 6.5 % in group 2A and a mean increase of 8.2 % in group 2B. The reduction of saturated fat in the diet is associated with a lipoprotein profile that would be expected to reduce cardiovascular risk. The reduction of dietary saturated fat with partial replacement of unsaturated fat brings about changes in total cholesterol, HDL- and LDL-cholesterol that are associated with a lower cardiovascular risk.

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Corresponding author
*Corresponding author: Professor Shanthi Mendis, fax +41 22 791 4259, email mendiss@who.ch
References
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Athukorala TMS & Jayawardane MIFP (1991) Lipid patterns and dietary habits of healthy subjects living in urban, suburban and rural areas. Ceylon Medical Journal 36, 916.
Cater NB, Heller HJ & Denke MA (1997) Comparison of the effects of medium-chain triacylglycerols, palm oil and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentration in humans. American Journal of Clinical Nutrition 65, 4145.
Chait AO, Akintunde Nicholl A, Rabaya E, Jeffrey D & Lewis B (1974) Reduction of serum triglyceride level by polyunsaturated fat. Atherosclerosis 20, 347364.
Connor WE & Connor SL (1997) Should low fat high carbohydrate diets be recommended for everyone?. New England Journal of Medicine 337, 562563.
Cullumbine H (1951) A nutritional survey in Ceylon. Ceylon Journal of Medical Science 8, 17.
Cullumbine H, Bibile SW & Wickramanayake TW (1946) A study of the diets of various communities in Ceylon. Ceylon Journal of Medical Science 6, 254.
Food and Agriculture Organization/World Health Organization (1998) Preparation and Use of Food-based Dietary Guidelines. Report of a Joint FAO/WHO Consultation. World Health Organization Technical Report Series no. 880.Geneva: WHO.
Glanz SA (1992) Primer of Biostatistics. New York, NY: McGraw-Hill.
Grundy SM (1997) Management of high serum cholesterol and related disorders in patients at risk for coronary heart disease. American Journal of Medicine 102, 1522.
Hegsted DM, Ausman LM, Johnson JA & Dallal GE (1993) Dietary fat and serum lipids; and evaluation of the experimental data. American Journal of Nutrition 57, 875883.
Hegsted DM, McGrandy RB & Myers ML (1965) Quantitative effects of dietary fat on serum cholesterol in man. American Journal of Clinical Nutrition 27, 281295.
Katan MB, Grundy SM & Willett WC (1997) Beyond low fat diets. New England Journal of Medicine 337, 563566.
Katan MB, Zock PL & Mensink RP (1995) Dietary oils, serum lipoproteins and coronary heart disease. American Journal of Clinical Nutrition 61 (Suppl. 6), 1368S1373S.
Kato H, Tillotson J, Nichamen MZ, Rhoads GG & Hamilton HB (1973) Epidemiological studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: serum lipids and diet. American Journal of Epidemiology 97, 372385.
Keys A (1980) Seven countries: a multivariate analysis of death and coronary heart disease. Cambridge, MA: Harvard University Press.
Keys A, Anderson JT & Grande F (1965) Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism 14, 776787.
Keys A, Grande F & Anderson JT (1974) Bias and misrepresentation revisited: perspective on saturated fat. American Journal of Clinical Nutrition 27, 188212.
Kinsella JE, Lokesh B & Stone RA (1990) Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms. Review. American Journal of Clinical Nutrition 52, 128.
Law MR, Wald NJ & Thompson SG (1994) By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. British Medical Journal 308, 367372.
Mattson FH & Grundy SM (1985) Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. Journal of Lipid Research 26, 194202.
Mendis S & Kumarasunderam R (1990) The effect of daily consumption of coconut fat and soyabean fat on plasma lipids and lipoproteins of young normolipidaemic men. British Journal of Nutrition 63, 547552.
Mendis S, Weissler RW & Bridenstein RT (1989) The effects of replacing coconut oil with corn oil on human serum lipid profiles and platelet derived factors active in atherogenesis. Nutrition Reports International 40, 773782.
Mensink RP & Katan MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arteriosclerosis and Thrombosis 12, 911919.
Miller GJ (1998) Effects of diet composition on coagulation pathways. American Journal of Nutrition 67 (Suppl. 3), 542S545S.
Nicholle L & Nimalasoouriya A (1949) Rural dietary surveys in Ceylon. Ceylon Journal of Medical Science 5, 59.
Parks EJ, Krauss RM, Christiansen MP, Neese RA & Hellerstein MK (1999) Effect of a low fat high carbohydrate diet on VLDL triglyceride assembly, production and clearance. Journal of Clinical Investigation 104, 10871205.
Perera WDA, Jayasekera PM & Thaha SZ (1979) Tables of Food Composition for use in Sri Lanka. Colombo, Sri Lanka: World Health Foundation of Sri Lanka.
Prior IA, Davidson F, Salmond CE & Czochanska Z (1981) Cholesterol coconut and diet in Polynesian atolls, a natural experiment: the Pukapuka and Toklau island studies. American Journal of Clinical Nutrition 32, 15521561.
Reiser R (1973) Saturated fat in the diet and serum cholesterol concentration: a critical examination of the literature. American Journal of Clinical Nutrition 26, 524555.
Riccardi G, Rivellese AA & Mancini M (1987) The use of diet to lower plasma cholesterol levels. European Heart Journal 8, (Suppl. E), 7985.
Robertson TL, Kato H, Rhoads GG, Kagan A, Marmot M, Syme SL, Gordon T, Worth RM, Belsky JL, Dock DS, Miyanishi M & Kawamoto S (1977) Epidemiological studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Incidence of myocardial infarction and death from coronary heart disease. American Journal of Cardiology 39, 239243.
Sanders TA, Oakley FR, Miller GJ, Mitropoulos KA, Crook D & Oliver MF (1997) Influence of n-6 versus n-3 polyunsaturated fatty acids in diets low in saturated fatty acids on plasma lipoproteins and hemostatic factors. Arteriosclerosis Thrombosis and Vascular Biology 17, 34493460.
Schafer EJ (1997) Effects of dietary fatty acids on lipoproteins and cardiovascular disease risk: summary. American Journal of Nutrition 65 (Suppl. 5), 1655S1656S.
Schafer EJ, Levy RI, Ernst ND, Van Sant FD & Brewer HB (1981) The effects of low cholesterol, high polyunsaturated fat diets on plasma lipid and lipoprotein cholesterol levels in normal and hypercholesterolemic subjects. American Journal of Clinical Nutrition 34, 17581763.
Schwandt P, Janetschek P & Wersweiler P (1982) High density lipoproteins unaffected by dietary fat modification. Atherosclerosis 44, 917.
Scrimshaw NS & Guzman MA (1968) Diet and atherosclerosis. Laboratory Investigations 18, 623628.
Shaper AG (1974) Coronary heart disease Cardiovascular Disease in the Tropics. [AG Shaper, MSR Hutt and Z Fejfar, editors]. London: BMA.
Shepherd J, Packard CJ, Grundy SM, Yeshurun D, Gotto AM & Taunton OD (1980) Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. Journal of Lipid Research 21, 9199.
Shrapnel WS, Calvert GD, Nestel PJ & Trustwell AS (1992) Diet and coronary heart disease. The National Heart Foundation of Australia. Medical Journal of Australia 156 Suppl., S9S16.
Stamler J, Wentworth D & Neaton JD (1986) Is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screeners of the multiple risk factor intervention trial (MRFIT). Journal of the American Medical Association 256, 28232828.
Vega GL, Groszek E, Wolf R & Grundy SM (1982) Influence of polyunsaturated fats on composition of plasma lipoproteins and apolipoproteins. Journal of Lipid Research 23, 811822.
Wahlefeld AW (1974) Triglyceride determination after enzymatic hydrolysis In Methods of Enzymatic Analysis. 18311833. [Berghmeyer HU, editor]. New York, NY and London: Verlag Chemie Weinheim and Academic Press Inc.
Warnick GR, Benderson J & Albers JJ (1982) Dextran-sulfate-Mg precipitation procedure for quantitation of high density lipoprotein cholesterol. Clinical Chemistry 28, 13791388.
Wickramanayake TW & Panabokke R (1961) The relation between diet and atherosclerosis in Ceylon. American Journal of Clinical Nutrition 9, 752.
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British Journal of Nutrition
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