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Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals

  • Estelle V. Lambert (a1), Julia H. Goedecke (a1), Kerry Bluett (a2), Kerry Heggie (a2), Amanda Claassen (a1), Dale E. Rae (a1), Sacha West (a1), Jonathan Dugas (a1), Lara Dugas (a1), Shelly Meltzer (a1), Karen Charlton (a2) and Inge Mohede (a3)...

Abstract

The aim of this study was to measure the effects of 12 weeks of conjugated linoleic acid (CLA) supplementation on body composition, RER, RMR, blood lipid profiles, insulin sensitivity and appetite in exercising, normal-weight persons. In this double-blind, randomised, controlled trial, sixty-two non-obese subjects (twenty-five men, thirty-seven women) received either 3·9 g/d CLA or 3·9 g high-oleic acid sunflower oil for 12 weeks. Prior to and after 12 weeks of supplementation, oral glucose tolerance, blood lipid concentrations, body composition (dual-energy X-ray absorptiometry and computerised tomography scans), RMR, resting and exercising RER and appetite were measured. There were no significant effects of CLA on body composition or distribution, RMR, RER or appetite. During the oral glucose tolerance tests, mean plasma insulin concentrations (0, 30, 120 min) were significantly lower (P = 0·04) in women who supplemented with CLA (24·3 (sd 9·7) to 20·4 (sd 8·5) μU/ml) compared to high-oleic acid sunflower oil control (23·7 (sd 9·8) to 26·0 (sd 8·8) μU/ml). Serum NEFA levels in response to oral glucose were attenuated in both men and women in the CLA (P = 0·001) compared to control group. However, serum total cholesterol and LDL-cholesterol concentrations decreased in both groups and HDL-cholesterol concentrations decreased in women over 12 weeks (P = 0·001, P = 0·02, P = 0·02, respectively). In conclusion, mixed-isomer CLA supplementation had a favourable effect on serum insulin and NEFA response to oral glucose in non-obese, regularly exercising women, but there were no CLA-specific effects on body composition, energy expenditure or appetite.

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Corresponding author

*Corresponding author: Professor Estelle V. Lambert, fax +27 21 6867530, email vlambert@sports.uct.ac.za

References

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Benito, P, Nelson, GJ, Kelley, DS, Bartolini, G, Schmidt, PC & Simon, V (2001) The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 36, 229236.
Blair, SN, Haskell, WL, Ho, P, Paffenbarger, RS Jr, Vranizan, KM, Farquhar, JW & Wood, PD (1985) Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am J Epidemiol 122, 794804.
Blankson, H, Stakkestad, JA, Fargertun, H, Thom, E, Wadstein, J & Gudmundsen, O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130, 29432948.
Eyjolfson, V, Spriet, LL & Dyck, DJ (2004) Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc 36, 814820.
Flint, A, Raben, A, Blundell, JE & Astrup, A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24, 3848.
Frayn, KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55, 628634.
Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499502.
Hawley, JA & Noakes, TD (1992) Peak sustained power output predicts VO2max and performance time in trained cyclists. Eur J Appl Physiol Occup Physiol 65, 7983.
Houseknecht, KL, Vanden Heuvel, JP, Moya-Camarena, SY, Portocarrero, CP, Peck, LW, Nickel, KP & Belury, MA (1998) Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244, 678682.
Kamphuis, MM, Lejeune, MP, Saris, WH & Westerterp-Plantenga, MS (2003 a) The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obes Relat Metab Disord 27, 840847.
Kamphius, MMJW, Lejeune, MPGM, Saris, WHM & Westerterp-Plantenga, MS (2003 b) The effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Eur J Clin Nutr 57, 12681274.
Matsuda, M & DeFronzo, RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycaemic insulin clamp. Diab Care 22, 14621470.
Matthews, DR, Hosker, JP, Rudenski, AS, Naylor, BA, Treacher, DF & Turner, RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.
Medina, EA, Horn, WF, Keim, NL, Havel, PJ, Benito, P, Kelley, D, Nelson, GJ & Erickson, KL (2000) Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids 35, 783788.
Moloney, F, Yeow, T, Mullen, A, Nolan, JJ & Roche, HM (2004) Conjugated linoleic acid supplementation: insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 80, 887895.
Noone, EJ, Roche, HM, Nugent, AP & Gibney, MJ (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243251.
Perseghin, G, Caumo, A, Caloni, M, Testolin, G & Luzi, L (2001) Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in non-obese individuals. J Clin Endocrinol Metab 86, 47764781.
Phillips, DIW, Clark, PM, Hales, CN & Osmond, C (1994) Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diab Med 11, 286292.
Rahman, SM, Wang, Y, Yotsumoto, H, Cha, J, Han, S, Inoue, S & Yanagita, T (2001) Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLEFT rats. Nutrition 17, 385390.
Risérus, U, Arner, P, Brismar, K & Vessby, B (2002) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabet Care 25, 15161521.
Risérus, U, Berglund, L & Vessby, B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25, 11291135.
Risérus, U, Vessby, B, Arnlov, J & Basu, S (2004 a) Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 80, 279283.
Risérus, U, Vessby, B, Arner, P & Zethelius, B (2004 b) Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 47, 10161019.
Sartorio, A, Lafortuna, CL, Vangeli, V, Tavani, A, Bosetti, C & La Vecchia, C (2001) Short-term changes of cardiovascular risk factors after a non-pharmacological body weight reduction program. Eur J Clin Nutr 55, 865869.
Stunkard, AJ & Messick, S (1985) The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29, 7183.
Terpstra, AH (2001) Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J Nutr 131, 20672068.
Thom, E, Wadstein, J & Gudmundsen, O (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29, 392396.
Yoshizumi, T, Nakamura, T, Yamane, M, Islam, AH, Menju, M, Yamasaki, K, Arai, T, Kotani, K, Funahashi, T, Yamashita, S & Matsuzawa, Y (1999) Abdominal fat: standardized technique for measurement at CT. Radiology 211, 283286.
Zambell, KL, Keim, NL, Van Loan, MD, Gale, B, Benito, P, Kelley, DS & Nelson, GJ (2000) Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 35, 777782.

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