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Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial

  • E. Guillemard (a1), F. Tondu (a1), F. Lacoin (a2) and J. Schrezenmeir (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114509991395
  • Published online: 14 September 2009
Abstract

Common infectious diseases (CID) of the airways and the gastrointestinal tract are still a considerable cause of morbidity and mortality in elderly. The present study examined the beneficial effect of a dairy product containing the probiotic strain Lactobacillus casei DN-114 001 (fermented product) on the resistance of free-living elderly to CID. The study was multicentric, double blind and controlled, involving 1072 volunteers (median age = 76·0 years) randomised for consumption of either 200 g/d of fermented (n 537) or control (non-fermented) dairy product (n 535) for 3 months, followed by an additional 1 month's follow-up. The results showed that, when considering all CID, the fermented product significantly reduced the average duration per episode of CID (6·5 v. 8 d in control group; P = 0·008) and the cumulative duration of CID (7 v. 8 d in control group; P = 0·009). Reduction in both episode and cumulative durations was also significant for all upper respiratory tract infections (URTI; P < 0·001) and for rhinopharyngitis (P < 0·001). This was accompanied with an increase of L. casei species in stools throughout the fermented product consumption (2–3·8 × 107 equivalents of colony-forming unit/g of stools, P < 0·001). The cumulative number of CID (primary outcome) was not different between groups nor was the CID severity, fever, pathogens' occurrence, medication, immune blood parameters and quality of life. The fermented product was safe and well tolerated. In conclusion, consumption of a fermented dairy product containing the probiotic strain L. casei DN-114 001 in elderly was associated with a decreased duration of CID in comparison with the control group, especially for URTI such as rhinopharyngitis.

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Corresponding author
*Corresponding author: E. Guillemard, fax +33 1 69 35 76 46, email eric.guillemard@danone.com
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1TT Yoshikawa (2000) Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis 30, 931933.

2G Gavazzi & KH Krause (2002) Ageing and infection. Lancet Infect Dis 2, 659666.

6K Goodwin , C Viboud & L Simonsen (2006) Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24, 11591169.

7JE McElhaney (2005) The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine 23, Suppl. 1, S10S25.

8PV Targonski , RM Jacobson & GA Poland (2007) Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 25, 30663069.

9KL Nichol (2003) The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines. Vaccine 21, 17691775.

10J Nikolich-Zugich (2008) Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat Rev Immunol 8, 512522.

11AD Delpedro , MJ Barjavel , Z Mamdouh , (1998) Signal transduction in LPS-activated aged and young monocytes. J Interferon Cytokine Res 18, 429437.

12JA McLachlan , CD Serkin , KM Morrey-Clark , (1995) Immunological functions of aged human monocytes. Pathobiology 63, 148159.

14J Mysliwska , A Mysliwski , P Romanowski , (1992) Monocytes are responsible for depressed natural killer (NK) activity in both young and elderly low NK responders. Gerontology 38, 4149.

15R Solana & E Mariani (2000) NK and NK/T cells in human senescence. Vaccine 18, 16131620.

16G Riezzo , M Chiloiro & F Russo (2005) Functional foods: salient features and clinical applications. Curr Drug Targets Immune Endocr Metabol Disord 5, 331337.

17PJ Jones & KA Varady (2008) Are functional foods redefining nutritional requirements? Appl Physiol Nutr Metab 33, 118123.

18HS Gill & F Guarner (2004) Probiotics and human health: a clinical perspective. Postgrad Med J 80, 516526.

21M Hickson , AL D'Souza , N Muthu , (2007) Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 335, 80.

25AC Ouwehand , N Bergsma , R Parhiala , (2008) Bifidobacterium microbiota and parameters of immune function in elderly subjects. FEMS Immunol Med Microbiol 53, 1825.

26A Klein , U Friedrich , H Vogelsang , (2008) Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp. lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr 62, 584593.

27M Kaila , E Isolauri , E Soppi , (1992) Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 32, 141144.

28D Bunout , G Barrera , S Hirsch , (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. J Parenter Enteral Nutr 28, 348354.

29M de Vrese , P Winkler , P Rautenberg , (2005) Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial. Clin Nutr 24, 481491.

31PJ Aggett , JM Antoine , NG Asp , (2005) PASSCLAIM: consensus on criteria. Eur J Nutr 44, Suppl. 1, i5i30.

33M Haarman & J Knol (2006) Quantitative real-time PCR analysis of fecal Lactobacillus species in infants receiving a prebiotic infant formula. Appl Environ Microbiol 72, 23592365.

36JM Graat , EG Schouten & FJ Kok (2002) Effect of daily vitamin E and multivitamin–mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 288, 715721.

38MD Parra , BE Martínez de Morentin , JM Cobo , (2004) Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people. J Physiol Biochem 60, 8591.

39A Marcos , J Warnberg , E Nova , (2004) The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114 001 on the immune response of subjects under academic examination stress. Eur J Nutr 43, 381389.

41K Hatakka , E Savilahti , A Ponka , (2001) Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322, 1327.

43NJ Cooper , AJ Sutton , KR Abrams , (2003) Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials. BMJ 326, 1235.

44FG Hayden (2004) Rhinovirus and the lower respiratory tract. Rev Med Virol 14, 1731.

45TG Wald , P Shult , P Krause , (1995) A rhinovirus outbreak among residents of a long-term care facility. Ann Intern Med 123, 588593.

46R Oozeer , A Leplingard , DD Mater , (2006) Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk. Appl Environ Microbiol 72, 56155617.

48V Rochet , L Rigottier-Gois , F Levenez , (2008) Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif. Can J Microbiol 54, 660667.

52P Pujol , J Huguet , F Drobnic , (2000) The effect of fermented milk containing Lactobacillus casei on the immune response to exercise. Sports Med Training and Rehab 9, 209223.

53E Tiollier , M Chennaoui , D Gomez-Merino , (2007) Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training. Mil Med 172, 10061011.

54T Boge , M Rémigy , S Vaudaine , (2009) A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine (epublication ahead of print version 15 July 2009).

55PM Sherman , JC Ossa & K Johnson-Henry (2009) Unraveling mechanisms of action of probiotics. Nutr Clin Pract 24, 1014.

57I Ingrassia , A Leplingard & A Darfeuille-Michaud (2005) Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Escherichia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial cells. Appl Environ Microbiol 71, 28802887.

58N Parassol , M Freitas , K Thoreux , (2005) Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells. Res Microbiol 156, 256262.

59J Wehkamp , J Harder , K Wehkamp , (2004) NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 72, 57505758.

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