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Diet and cognitive decline at middle age: the role of antioxidants

  • Astrid C. J. Nooyens (a1), Ivon E. J. Milder (a1), Boukje M. van Gelder (a1), H. Bas Bueno-de-Mesquita (a1) (a2) (a3) (a4), Martin P. J. van Boxtel (a5) and W. M. Monique Verschuren (a1) (a6)...
Abstract

To assess the relationship between dietary intake of antioxidants (vitamin C, vitamin E, β-carotene, lutein, flavonoids and lignans) and cognitive decline at middle age, analyses were performed on data from the population based Doetinchem Cohort Study. Habitual diet and cognitive function were assessed twice with a 5-year interval in 2613 persons aged 43–70 year at baseline (1995–2002). Diet was assessed with a validated 178-item semi-quantitative FFQ. Cognitive function was assessed with a neuropsychological test battery, consisting of the 15 Words Learning Test, the Stroop Test, the Word Fluency test, and the Letter Digit Substitution Test. Scores on global cognitive function, memory, processing speed, and cognitive flexibility were calculated. In regression analyses, quintiles of antioxidant intake were associated with change in cognitive domain scores. Results showed that higher lignan intake was linearly associated with less decline in global cognitive function (P= 0·01), memory (P< 0·01) and processing speed (P= 0·04), with about two times less declines in the highest v. the lowest quintile. In the lowest quintile of vitamin E intake, decline in memory was twice as fast as in all higher quintiles (P< 0·01). Global cognitive decline in the highest lutein intake group was greater than in the lowest intake group (P< 0·05). Higher flavonoid intake was associated with greater decline in cognitive flexibility (P for trend = 0·04). Intakes of other antioxidants were not associated with cognitive decline. We conclude that within the range of a habitual dietary intake, higher intake of lignans is associated with less cognitive decline at middle age.

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Corresponding author
* Corresponding author: Dr A. C. J. Nooyens, fax +31 30 274 4407, email astrid.nooyens@rivm.nl
References
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1 Bourre, JM (2006) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J Nutr Health Aging 10, 377385.
2 McDaniel, MA, Maier, SF & Einstein, GO (2003) “Brain-specific” nutrients: a memory cure? Nutrition 19, 957975.
3 Kesse-Guyot, E, Fezeu, L, Andreeva, VA, et al. (2012) Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr 142, 7683.
4 Kesse-Guyot, E, Fezeu, L, Jeandel, C, et al. (2011) French adults' cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial. Am J Clin Nutr 94, 892899.
5 Peacock, JM, Folsom, AR, Knopman, DS, et al. (2000) Dietary antioxidant intake and cognitive performance in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) study investigators. Public Health Nutr 3, 337343.
6 Letenneur, L, Proust-Lima, C, Le Gouge, A, et al. (2007) Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 165, 13641371.
7 Devore, EE, Kang, JH, Stampfer, MJ, et al. (2010) Total antioxidant capacity of diet in relation to cognitive function and decline. Am J Clin Nutr 92, 11571164.
8 Kalmijn, S, Feskens, EJ, Launer, LJ, et al. (1997) Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 145, 3341.
9 Morris, MC, Evans, DA, Bienias, JL, et al. (2002) Vitamin E and cognitive decline in older persons. Arch Neurol 59, 11251132.
10 Commenges, D, Scotet, V, Renaud, S, et al. (2000) Intake of flavonoids and risk of dementia. Eur J Epidemiol 16, 357363.
11 Luchsinger, JA, Tang, MX, Shea, S, et al. (2003) Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 60, 203208.
12 Engelhart, MJ, Geerlings, MI, Ruitenberg, A, et al. (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287, 32233229.
13 Morris, MC, Evans, DA, Bienias, JL, et al. (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287, 32303237.
14 Verschuren, WMM, Blokstra, A, Picavet, HSJ, et al. (2008) Cohort profile: the Doetinchem Cohort Study. Int J Epidemiol 37, 12361241.
15 Nooyens, AC, Bueno-de-Mesquita, HB, van Boxtel, MP, et al. (2011) Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Br J Nutr 106, 752761.
16 de Groot, JC, de Leeuw, FE, Oudkerk, M, et al. (2000) Cerebral white matter lesions and cognitive function: the Rotterdam Scan study. Ann Neurol 47, 145151.
17 Møller, JT, Cluitmans, P, Rasmussen, LS, et al. (1998) Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of Post-Operative Cognitive Dysfunction. Lancet 351, 857861.
18 Durga, J, van Boxtel, MP, Schouten, EG, et al. (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 369, 208216.
19 Ocké, MC, Bueno-de-Mesquita, HB, Goddijn, HE, et al. (1997) The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups. Int J Epidemiol 26, Suppl. 1, S37S48.
20 Ocké, MC, Bueno-de-Mesquita, HB, Pols, MA, et al. (1997) The Dutch EPIC food frequency questionnaire. II. Relative validity and reproducibility for nutrients. Int J Epidemiol 26, Suppl. 1, S49S58.
21 NEVO Foundation, (editor) (1996) Dutch Food Composition Database 1996 (NEVO) [In Dutch] . Den Haag: Voorlichtingsbureau voor de voeding.
22 Hertog, MGL, Hollman, PCH & Katan, MB (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem 40, 23792383.
23 Hertog, MGL, Hollman, PCH & van de Putte, B (1993) Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J Agric Food Chem 41, 12421246.
24 Arts, IC, van De Putte, B & Hollman, PC (2000) Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. J Agric Food Chem 48, 17521757.
25 Arts, IC, van de Putte, B & Hollman, PC (2000) Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J Agric Food Chem 48, 17461751.
26 Milder, IE, Arts, IC, van de Putte, B, et al. (2005) Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol. Br J Nutr 93, 393402.
27 NEVO-online (2013) NEVO-online version 2013/4.0. Bilthoven, the Netherlands: RIVM. http://nevo-online.rivm.nl.
28 Pols, MA, Peeters, PH, Ocke, MC, et al. (1997) Estimation of reproducibility and relative validity of the questions included in the EPIC Physical Activity Questionnaire. Int J Epidemiol 26, Suppl. 1, S181S189.
29 Wareham, NJ, Jakes, RW, Rennie, KL, et al. (2003) Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 6, 407413.
30 Van der Zee, KI and Sanderman, R (editors) (1993) Het meten van de algemene gezondheidstoestand met de RAND-36: een handleiding (Measuring the General Health Status with the RAND-36: A Manual). Groningen, the Netherlands: Noordelijk Centrum voor Gezondheidsvraagstukken.
31 Ware, JEJ & Sherbourne, CD (1992) The MOS36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30, 473483.
32 Willett, W (editor) (1998) Nutritional Epidemiology, 2nd ed. New York, NY: Oxford University Press.
33 Crichton, GE, Bryan, J & Murphy, KJ (2013) Dietary antioxidants, cognitive function and dementia – a systematic review. Plant Foods Hum Nutr 68, 279292.
34 Rafnsson, SB, Dillis, V & Trichopoulou, A (2013) Antioxidant nutrients and age-related cognitive decline: a systematic review of population-based cohort studieds. Eur J Nutr 52, 15531567.
35 Li, FJ, Shen, L & Ji, HF (2012) Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis. J Alzheimers Dis 31, 253258.
36 Marangon, K, Herbeth, B, Lecomte, E, et al. (1998) Diet, antioxidant status, and smoking habits in French men. Am J Clin Nutr 67, 231239.
37 Laurin, D, Masaki, KH, Foley, DJ, et al. (2004) Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging study. Am J Epidemiol 159, 959967.
38 Yaffe, K, Clemons, TE, McBee, WL, et al. (2004) Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial. Neurology 63, 17051707.
39 Kang, JH, Cook, NR, Manson, JE, et al. (2009) Vitamin E, vitamin C, β-carotene, and cognitive function among women with or at risk of cardiovascular disease: the Women's Antioxidant and Cardiovascular study. Circulation 119, 27722780.
40 Petersen, RC, Thomas, RG, Grundman, M, et al. (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352, 23792388.
41 Harrison, FE (2012) A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J Alzheimers Dis 29, 711726.
42 Johnson, EJ (2014) Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev 72, 605612.
43 Johnson, EJ (2012) A possible role for lutein and zeaxanthin in cognitive function in the elderly. Am J Clin Nutr 96, 1161S1165S.
44 Nooyens, ACJ, van Gelder, BM & Verschuren, WMM (2008) Smoking and cognitive decline among middle-aged men and women: the Doetinchem Cohort Study. Am J Public Health 98, 22442250.
45 Milder, IE, Feskens, EJ, Arts, IC, et al. (2005) Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and women. J Nutr 135, 12021207.
46 Heinonen, S, Nurmi, T, Liukkonen, K, et al. (2001) In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J Agric Food Chem 49, 31783186.
47 Milder, IEJ (2007) Lignan Intake in The Netherlands and Its Relation with Mortality. Wageningen: Wageningen University.
48 Joseph, JA, Shukitt-Hale, B, Casadesus, G, et al. (2005) Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochem Res 30, 927935.
49 Cornwell, T, Cohick, W & Raskin, I (2004) Dietary phytoestrogens and health. Phytochemistry 65, 9951016.
50 Kreijkamp-Kaspers, S, Kok, L, Grobbee, DE, et al. (2007) Dietary phytoestrogen intake and cognitive function in older women. J Gerontol A Biol Sci Med Sci 62, 556562.
51 Nooyens, AC, Bueno-de-Mesquita, HB, van Gelder, BM, et al. (2014) Consumption of alcoholic beverages and cognitive decline at middle age: the Doetinchem Cohort Study. Br J Nutr 111, 715723.
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