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British Journal of Nutrition British Journal of Nutrition

Article contents

Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women

Published online by Cambridge University Press:  15 February 2013

Thaís da Silva Ferreira ,
Márcia Regina Simas Gonçalves Torres  and
Antonio Felipe Sanjuliani
Thaís da Silva Ferreira*
Affiliation:
Discipline of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Avenida 28 de Setembro, 87 – Rooms 363 and 361, Vila Isabel, Rio de Janeiro, CEP20551-030, Brazil
Márcia Regina Simas Gonçalves Torres
Affiliation:
Discipline of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Avenida 28 de Setembro, 87 – Rooms 363 and 361, Vila Isabel, Rio de Janeiro, CEP20551-030, Brazil
Antonio Felipe Sanjuliani
Affiliation:
Discipline of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Avenida 28 de Setembro, 87 – Rooms 363 and 361, Vila Isabel, Rio de Janeiro, CEP20551-030, Brazil
*
*Corresponding author: T. da Silva Ferreira, fax +55 21 2334 2063, email thaissferreira@gmail.com
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Abstract

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Recent studies have suggested that dietary Ca may have beneficial effects on adiposity, insulin resistance, dyslipidaemia and blood pressure (BP). One potential mechanism underlying these benefits involves modifications in intracellular Ca concentration ([Ca2+]i). The present study aimed to evaluate the associations of dietary Ca with adiposity, erythrocyte [Ca2+]i, metabolic profile, BP, inflammatory state and endothelial function in healthy pre-menopausal women. In the present cross-sectional study, seventy-six women aged 18–50 years were submitted to the evaluation of dietary intake, anthropometric parameters, body composition, erythrocyte [Ca2+]i, biochemical variables, endothelial function and BP. A FFQ was used to assess usual dietary intake. Endothelial function was evaluated by serum concentrations of adhesion molecules and by the peripheral arterial tonometry (PAT) method, using Endo-PAT 2000®. Participants were allocated into two groups according to Ca intake: low-Ca group (LCG; n 32; < 600 mg/d) and high-Ca group (HCG; n 44; ≥ 600 mg/d). Women in the LCG compared with those in the HCG exhibited, after adjustments for potential confounders, higher values of BMI, waist circumference, waist:height ratio, percentage of body fat, insulin, homeostasis model assessment of insulin resistance, leptin, diastolic and mean BP; and lower levels of HDL-cholesterol, adiponectin and vascular cell adhesion molecule 1. Endothelial function assessed by PAT and [Ca2+]i was similar in both groups. Subjects in the HCG had lower OR for prevalent overweight, obesity, abdominal obesity, insulin resistance, HDL-cholesterol < 600 mg/l and systolic BP >120 mmHg. The findings of the present study suggest that high Ca intake is inversely associated with some cardiovascular risk factors.

Keywords

Dietary calciumAdiposityMetabolic profileIntracellular calciumEndothelial function
Type
Full Papers
Information
British Journal of Nutrition , Volume 110 , Issue 6 , 28 September 2013 , pp. 1079 - 1088
Copyright
Copyright © The Authors 2013 

References

1Low, S, Chin, MC & Deurenberg-Yap, M (2009) Review on epidemic obesity. Ann Acad Med Sing 38, 57–65.Google Scholar
2Instituto Brasileiro de Geografia e Estatística (2010) Pesquisa de Orçamentos Familiares 2008–2009: análise da disponibilidade domiciliar de alimentos e do estado nutricional no Brasil. Rio de Janeiro: IBGE.Google Scholar
3Lavie, CJ, Milani, RV & Ventura, HO (2009) Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 53, 1925–1932.CrossRefGoogle ScholarPubMed
4Tsigos, C, Hainer, V, Basdevant, A, et al. (2008) Management of obesity in adults: European clinical practice guidelines. Obes Facts 1, 106–116.CrossRefGoogle ScholarPubMed
5Bessesen, DH (2008) Update on obesity. J Clin Endocrinol Metab 93, 2027–2034.CrossRefGoogle ScholarPubMed
6Zemel, MB (2005) The role of dairy foods in weight management. J Am Coll Nutr 24, 537S–546S.CrossRefGoogle ScholarPubMed
7Dougkas, A, Reynolds, CK, Givens, ID, et al. (2011) Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms. Nutr Res Rev 24, 72–95.CrossRefGoogle ScholarPubMed
8Pereira, MA, Jacobs, DR, Horn, LV, et al. (2002) Dairy consumption, obesity, and the insulin resistance syndrome in young adults. The CARDIA study. JAMA 287, 2081–2089.CrossRefGoogle ScholarPubMed
9Jacqmain, M, Doucet, E, Després, J, et al. (2003) Calcium intake, body composition, and lipoprotein–lipid concentrations in adults. Am J Clin Nutr 77, 1448–1452.CrossRefGoogle ScholarPubMed
10Barr, SI, Fulgoni, VI & Pereira, MI (2004) Relationship of calcium or dairy product intakes on percent body fat, BMI, and anthropometric measures in NHANES-III. FASEB J 18, A583.8 (abstr).Google Scholar
11Loss, RJF, Rankinen, T, Leon, AS, et al. (2004) Calcium intake is associated with adiposity in black and white men and white women of the HERITAGE Family Study. J Nutr 134, 1772–1778.CrossRefGoogle Scholar
12Soares, MJ, Binns, C & Lester, L (2004) Higher intakes of calcium are associated with lower BMI and waist circumference in Australian adults: an examination of the 1995 National Nutrition Survey. Asia Pac J Clin Nutr 13, Suppl., S56.Google Scholar
13Marques-Vidal, P, Gonçalves, A & Dias, CM (2006) Milk intake is inversely related to obesity in men and in young women: data from the Portuguese Health Interview Survey 1998–1999. Int J Obes 30, 89–93.CrossRefGoogle ScholarPubMed
14Eilat-Adar, S, Xu, J, Loria, C, et al. (2007) Dietary calcium is associated with body mass index and body fat in American Indians. J Nutr 137, 1955–1960.CrossRefGoogle ScholarPubMed
15Zemel, MB, Thompson, W, Milstead, A, et al. (2004) Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 12, 582–590.CrossRefGoogle ScholarPubMed
16Zemel, MB, Richards, J, Milstead, A, et al. (2005) Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res 13, 1218–1225.CrossRefGoogle ScholarPubMed
17Faghih, S, Abadi, AR, Hedayati, M, et al. (2011) Comparison of the effects’ of cow's milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight women. Nutr Metab Cardiovasc Dis 21, 499–503.CrossRefGoogle Scholar
18Harvey-Berino, J, Gold, BC, Lauber, R, et al. (2005) The impact of calcium and dairy product consumption on weight loss. Obes Res 13, 1720–1726.CrossRefGoogle ScholarPubMed
19Palacios, C, Bertra'n, JJ, Ríos, RE, et al. (2011) No effects of low and high consumption of dairy products and calcium supplements on body composition and serum lipids in Puerto Rican obese adults. Nutrition 27, 520–525.CrossRefGoogle ScholarPubMed
20Van Loan, M (2009) The role of dairy foods and dietary calcium in weight management. J Am Coll Nutr 28, 120S–129S.CrossRefGoogle ScholarPubMed
21Vaskonen, T (2003) Dietary minerals and modification of cardiovascular risk factors. J Nutr Biochem 14, 492–506.CrossRefGoogle ScholarPubMed
22Institute of Medicine (2010) Dietary Reference Intakes for Calcium and Vitamin D. Report Brief 2010. Washington, DC: IOM.Google Scholar
23Astrup, A, Kristensen, M, Gregersen, NT, et al. (2010) Can bioactive foods affect obesity? Ann NY Acad Sci 1190, 25–41.CrossRefGoogle ScholarPubMed
24Wang, L, Manson, JE, Buring, JE, et al. (2008) Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 51, 1–7.CrossRefGoogle ScholarPubMed
25Engberink, MF, Hendriksen, MAH, Schouten, EG, et al. (2009) Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr 89, 1877–1883.CrossRefGoogle ScholarPubMed
26vanMierlo, LA, Arends, LR, Streppel, MT, et al. (2006) Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens 20, 571–580.CrossRefGoogle Scholar
27Tremblay, A & Gilbert, J (2009) Milk products, insulin resistance syndrome and type 2 diabetes. J Am Coll Nutr 28, 91S–102S.CrossRefGoogle ScholarPubMed
28Richart, T, Thijs, L, Nawrot, T, et al. (2010) The metabolic syndrome and carotid intima–media thickness in relation to the parathyroid hormone to 25-OH-D3 ratio in a general population. Am J Hypert 24, 102–109.CrossRefGoogle Scholar
29Lorenzen, JK & Astrup, A (2011) Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet. Br J Nutr 105, 1823–1831.CrossRefGoogle ScholarPubMed
30Panagiotakos, DB, Pitsavos, CH, Zampelas, AD, et al. (2010) Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults: the ATTICA study. J Am Coll Nutr 29, 357–364.CrossRefGoogle ScholarPubMed
31Zemel, MB, Sun, X, Sobhani, T, et al. (2010) Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Am J Clin Nutr 91, 16–22.CrossRefGoogle ScholarPubMed
32Esmaillzadeh, A & Azadbakht, L (2009) Dairy consumption and circulating levels of inflammatory markers among Iranian women. Public Health Nutr 13, 1395–1402.CrossRefGoogle ScholarPubMed
33Zemel, MB & Sun, X (2008) Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 138, 1047–1052.CrossRefGoogle ScholarPubMed
34Stancliffe, RA, Thorpe, T & Zemel, MB (2011) Dairy attenuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr 94, 422–430.CrossRefGoogle ScholarPubMed
35Torres, MRSG, Ferreira, TS, Carvalho, DC, et al. (2011) Dietary calcium intake and its relationship with adiposity and metabolic profile in hypertensive patients. Nutrition 27, 666–671.CrossRefGoogle ScholarPubMed
36Sichieri, R & Everhart, JE (1998) Validity of a Brazilian frequency questionnaire against dietary recalls and estimated energy intake. Nutr Res 8, 1649–1659.CrossRefGoogle Scholar
37Mathews, DR, Hosker, JP, Treacher, DF, et al. (1985) Homeostasis model assessment insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28, 412–419.CrossRefGoogle Scholar
38Friedewald, WT, Levy, RI & Frederickson, DS (1972) Estimation of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499–502.Google ScholarPubMed
39Cheng, J, Feinfeld, DA, Briscoe, AM, et al. (1987) Erythrocyte sodium and potassium in patients on peritoneal dialyses. Am J Kidney Dis 99, Suppl. 3, 211–216.CrossRefGoogle Scholar
40Bonetti, PO, Pumper, GM, Higano, ST, et al. (2004) Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 44, 2137–2141.CrossRefGoogle ScholarPubMed
41Kuvin, JT, Patel, AR, Sliney, KA, et al. (2003) Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 146, 168–174.CrossRefGoogle ScholarPubMed
42World Health Organization (2000) Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation. WHO Technical Report Series no. 894. Geneva: WHO.Google Scholar
43Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) (2001) JAMA 285, 2486–2497.CrossRefGoogle Scholar
44American Diabetes Association (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32, S62–S67.CrossRefGoogle Scholar
45Sociedade Brasileira de Diabetes (2009) Diretrizes da Sociedade Brasileira de Diabetes (Guidelines of the Brazilian Society of Diabetes), 3rd ed.Itapevi: SBD.Google Scholar
46Chobanian, AV, Bakris, GL, Black, HR, et al. (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42, 1206–1252.CrossRefGoogle ScholarPubMed
47Subar, AF, Thompson, FE, Kipnis, V, et al. (2001) Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: The Eating at America's Table Study. Am J Epidemiol 154, 1089–1099.CrossRefGoogle ScholarPubMed
48Azadbakht, L, Mirmiran, P, Esmaillzadeh, A, et al. (2005) Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults. Am J Clin Nutr 82, 523–530.CrossRefGoogle ScholarPubMed
49Dicker, D, Belnic, Y, Goldsmith, R, et al. (2008) Relationship between dietary calcium intake, body mass index, and waist circumference in MABAT – the Israeli National Health and Nutrition Study. Isr Med Assoc J 10, 512–515.Google ScholarPubMed
50Shahar, DR, Schwarzfuchs, D, Fraser, D, et al. (2010) Dairy calcium intake, serum vitamin D, and successful weight loss. Am J Clin Nutr 92, 1017–1022.Google ScholarPubMed
51Torres, MR, Gioseffi, C, Guimarães, SS, et al. (2011) A pilot study on the relation between dietary calcium and clinical parameters in renal transplant recipients. J Ren Nutr 21, 418–425.CrossRefGoogle ScholarPubMed
52Shahar, DR, Abel, R, Elhayany, A, et al. (2007) Does dairy calcium intake enhance weight loss among overweight diabetic patients? Diabetes Care 30, 485–489.CrossRefGoogle ScholarPubMed
53Murakami, K, Okubo, H & Sasaki, S (2006) No relation between intakes of calcium and dairy products and body mass index in Japanese women aged 18 to 20 y. Nutrition 2, 490–495.CrossRefGoogle Scholar
54Boon, N, Kopes, LLJ & Saris, WHM (2005) The relation between calcium intake and body composition in a Dutch population. Am J Epidemiol 162, 27–32.CrossRefGoogle Scholar
55Hilpert, KF, West, SG, Bagshaw, DM, et al. (2009) Effects of dairy products on intracellular calcium and blood pressure in adults with essential hypertension. J Am Coll Nutr 28, 142–149.CrossRefGoogle ScholarPubMed
56Kosch, M, Hausberg, M, Westermann, G, et al. (2001) Alterations in calcium and magnesium content of red cell membranes in patients with primary hypertension. Am J Hypert 14, 254–258.CrossRefGoogle ScholarPubMed
57Barbagallo, M, Dominguez, LJ, Licata, G, et al. (1999) Effects of aging on serum ionized and cytosolic free calcium: relation to hypertension and diabetes. Hypertension 34, 902–906.CrossRefGoogle ScholarPubMed
58Byyny, R, Lo Verde, M, Lloyd, S, et al. (1992) Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Am J Hypertens 5, 459–464.CrossRefGoogle ScholarPubMed
59Zemel, MB (2001) Calcium modulation of hypertension and obesity: mechanisms and implications. J Am Coll Nutr 20, Suppl., 428S–435S.CrossRefGoogle ScholarPubMed
60Liu, S, Song, Y, Ford, ES, et al. (2005) Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care 28, 2926–2932.CrossRefGoogle ScholarPubMed
61Reid, IR, Mason, B, Horne, A, et al. (2002) Effects of calcium supplementation on serum lipid concentrations in normal older women: a randomized controlled trial. Am J Med 112, 343–347.CrossRefGoogle ScholarPubMed
62Rice, BH, Cifelli, CJ, Pikosky, MA, et al. (2011) Dairy components and risk factors for cardiometabolic syndrome: recent evidence and opportunities for future research. Adv Nutr 2, 396–407.CrossRefGoogle ScholarPubMed
63Ronti, T, Lupattelli, G & Mannarino, E (2006) The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 64, 355–365.Google ScholarPubMed
64Hadi, HAR, Carr, CS & Suwaidi, JAI (2005) Endothelium dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Healt Risk Manag 1, 183–198.Google ScholarPubMed
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Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women
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Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women
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Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women
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