1 Turley SD (1999) Dietary cholesterol and the mechanism of cholesterol absorption. Eur Heart J 1, Supp., S29–S35.
2 Carr TP & Jesch FD (2006) Food components that reduce cholesterol absorption. Adv Food Nutr Res 51, 165–204.
3 Kruit JK, Ploscht J, Havinga R, et al. (2005) Increased fecal neutral sterol loss upon liver X receptor activation is independant of biliary sterol secretion in mice. Gastroenterology 128, 147–156.
4 Wilson MD & Rudel LL (1994) Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J Lip Res 35, 943–955.
5 Samuel P & Mc Namara DJ (1983) Differential absorption of exogenous and endogenous cholesterol in man. J Lipid Res 24, 265–276.
6 Dawson PA & Rudel LL (1999) Intestinal cholesterol absorption. Curr Opin Lipidol 10, 315–320.
7 Hauser H, Dyer JH, Nandy A, et al. (1998) Identification of a receptor mediating absorption of dietary cholesterol in the intestine. Biochemistry 37, 17843–17850.
8 Wang DQ & Carey MC (2002) Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-B1. Biochim Biophys Acta 1583, 141–150.
9 Altmann SW, Davis HR, Zhu LJ, et al. (2004) Niemman-Pick C1 like protein is critical for intestinal cholesterol absorption. Science 303, 1201–1204.
10 Smart EJ, Derose RA & Farber SA (2004) Annexin 2 caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proc Natl Acad Sci USA 101, 3450–3455.
11 Ostlund RE (2007) Phytosterols, cholesterol absorption and healthy diets. Lipids 42, 41–45.
12 Plat J & Mensink RP (2005) Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. Am J Cardiol 96, Suppl., 15D–22D.
13 Plōsch T, Kok T, Bloks VW, et al. (2002) Increased hepato-biliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 277, 33870–33877.
14 Gylling H & Miettinen TA (1992) Cholesterol absorption, and synthesis related to low density lipoprotein metabolism during LDL kinetics during varying cholesterol intake in men with different apo E phenotypes. J Lipid Res 33, 1361–1371.
15 Kesaniemi YA, Ehnholm C & Miettinen TA (1987) Intestinal cholesterol efficiency in man is related to apoprotein E polymorphism. J Lip Res 80, 578–581.
16 Pedro-Botet J, Schaefer EJ, Bakker-Arrema RG, et al. (2001) Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner. Atherosclerosis 158, 183–193.
17 Lammert F & Wang DQ (2005) New insights into the genetic regulation on intestinal cholesterol absorption. Gastroenterology 129, 718–734.
18 Mac Murray MP, Connor WE, Lin DS, et al. (1985) The absorption of cholesterol and the sterol balance in the Tarahumara Indians of Mexico fed cholesterol-free and high cholesterol diets. Am J Clin Nutr 41, 128–138.
19 Sudhop T, Lütjohann D, Kodal A, et al. (2002) Inhibition of intestinal absorption by ezetimibe in humans. Circulation 106, 1943–1948.
20 Clarenbach JJ, Reber M, Lütjohann D, et al. (2006) The lipid lowering effect of ezetimibe in pure vegetarians. J Lipid Res 47, 2820–2824.
21 Wang DQH (2002) Aging per se is an independant risk factor for gallstone formation in gallstone susceptible mice. J Lipid Res 43, 1950–1959.
22 Bosner MS, Ostlund RE, Osofisan O, et al. (1993) Assessment of percent cholesterol absorption in humans with stable isotopes. J Lipid Res 34, 1047–1053.
23 Ostlund RE, Bosner MS & Stenson NF (1999) Cholesterol absorption efficiency declines at moderate dietary doses in normal human subjects. J Lipid Res 40, 1453–1458.
24 Sachs FM, Salazar J, Miller L, et al. (1984) Ingestion of egg raises plasma low density lipoproteins in free-living subjects. Lancet 1, 647–649.
25 Vuoristo M & Miettinen TA (1994) Absorption modulation and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding. Am J Clin Nutr 59, 1325–1331.
26 Mac Namara DJ, Kolb R, Parker TS, et al. (1987) Heterogeneity of cholesterol homeostasis in man. J Clin Invest 79, 1729–1739.
27 Hegsted DM (1986) Serum cholesterol response to dietary cholesterol: a re-evaluation. Am J Clin Nutr 44, 299–305.
28 Apfelbaum M (1992) Which is the nutritional advantage of the consumption of a free-cholesterol butter? Rev Prat 42, 1925–1926.
29 Weggemans RM, Zock PL & Katan MB (2001) Dietary cholesterol from eggs increases the ratio of total cholesterol to high density lipoprotein cholesterol in humans: a meta-analysis. Am J Clin Nutr 73, 885–891.
30 Vorster HH, Benade AJ, Barnard HC, et al. (1992) Egg does not change plasma lipoprotein and coagulation profiles. Am J Clin Nutr 55, 400–410.
31 Tillotson JL, Bartsch GE, Gorder D, et al. (1997) Food group and nutrient intakes at baseline in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr 65, Suppl. 1, 228S–257S.
32 Kern F (1991) Normal plasma cholesterol of an 88 year old man who eats 25 eggs a day. Mechanisms of adaptation. N Engl J Med 324, 896–897.
33 Simons LA, Von Konigsmark M, Simons J, et al. (1993) Effect of an egg per day on plasma cholesterol levels in moderate hypercholesterolemia. Nutr Metab Cardiovasc Dis 3, 78–82.
34 Edington J, Geekie R, Carter R, et al. (1987) Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet. Br Med J 294, 333–336.
35 Fielding CJ, Havel RJ, Todd KM, et al. (1995) Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men. J Clin Invest 95, 61–68.
36 Harman NL, Leeds AR & Griffin BA (2008) Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss. Eur J Clin 47, 287–293.
37 Kestin M, Clifton PM, Rouse IK, et al. (1989) Effect of dietary cholesterol in normolipidemic subjects is not modified by nature and amount of dietary fat. Am J Clin Nutr 50, 528–532.
38 Ginsberg HN, Karmally W, Siddiqui M, et al. (1995) Increases in dietary cholesterol are associated with modest increases in both LDL and HDL cholesterol in healthy young women. Arterioscler Thromb Vasc Biol 15, 169–178.
39 Mutungi G, Ratliff J & Puglisi M (2008) Dietary cholesterol from eggs increases plasma cholesterol in overweight men consuming a carbohydrate restricted diet. J Nutr 138, 272–276.
40 Green CM, Zern TL & Wood RJ (2005) Maintenance of the LDL cholesterol/HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge. J Nutr 135, 2793–2798.
41 Sutherland WHF, Ball MJ & Walker H (1997) The effect of increased egg consumption on plasma cholesteryl ester transfer activity in healthy subjects. Eur J Clin Nutr 51, 172–176.
42 Rader DJ (2007) Illuminating HDL – is it still a viable therapeutic target? N Engl J Med 357, 2180–2183.
43 Ordovas JM & Schaeffer EJ (1999) Genes, variation of cholesterol and fat intake and serum lipids. Curr Opin Lipidol 10, 15–22.
44 Sarkkinen E, Kurhonen M, Erkkila A, et al. (1998) Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. Am J Clin Nutr 68, 1215–1222.
45 Gylling H, Strandberg T & Tilvis R (1994) Regulation of serum cholesterol level in middle-aged and elderly men. Relation of cholesterol absorption and synthesis to lipoprotein metabolism. Arterioscler Thromb 14, 694–700.
46 Jones PJ (1997) Regulation of cholesterol biosynthesis by diet in humans. Am J Clin Nutr 66, 438–446.
47 Mustad VA, Ellsworth JF & Cooper AD (1996) Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. J Lipid Res 37, 2310–2323.
48 Jones PJH, Pappu AS, Hatcher L, et al. (1996) Dietary cholesterol feeding suppresses human cholesterol synthesis measured by deuterium incorporation and urinary mevalonic acid levels. Arterioscler Thromb Vasc Dis 16, 1222–1228.
49 Miettinen TA & Kesaniemi YA (1989) Cholesterol absorption: regulation of cholesterol synthesis and elimination and within population variations of serum cholesterol levels. Am J Clin Nutr 49, 629–635.
50 Gylling H & Miettinen TA (2002) Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. J Lipid Res 43, 1472–1476.
51 Asztalos B, Lefebvre M, Wong L, et al. (2000) Differential response to low-fat diet between low and normal HDL cholesterol subjects. J Lipid Res 41, 321–328.
52 Rantala M, Rantala TT & Savolainen MJ (2000) Apoliprotein B gene polymorphisms and serum lipids: meta analysis of the role of genetic variation to diet. Am J Clin Nutr 71, 713–724.
53 Masson LF, Mc Neill G & Avenell A (2003) Genetic variation and the lipid response to dietary intervention: a systematic review. Am J Clin Nutr 77, 1098–1111.
54 Aitken WAE, Chisolma WAH, Duncan AW, et al. (2006) Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat. Nutr Metab Cardiovasc Dis 16, 353–363.
55 Tchernof A (2007) Visceral adipocytes and the metabolic syndrome. Nutr Rev 95, Suppl., S24–S29.
56 Ritchie SA & Connell JMC (2007) The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 17, 319–326.
57 Gylling H & Miettinen TA (2005) Cholesterol absorption: influence of body weight and the role of plant sterols. Curr Atherosclerosis Rep 7, 466–467.
58 Lamon-Fava S, Diffenderfer MR, Barrett PH, et al. (2007) Effects of different doses of atovastatin on human apolipoprotein B-100, B48, and A1 metabolism. J Lipid Res 48, 1748–1753.
59 Van Himbergen T, Matthan NR, Restegnini NA, et al. (2009) Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. J Lipid Res 30, 730–739.
60 Hedman M, Miettinen TA, Gylling H, et al. (2006) Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. J Pediatr 148, 241–246.
61 Miettinen TA & Gylling H (2002) Ineffective decrease cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. Atherosclerosis 164, 147–152.
62 Miettinen TA, Strandberg TE & Gylling H (2000) Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol 20, 1340–1346.
63 Miettinen TA, Gylling H, Strandberg T, et al. (1998) Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. BMJ 316, 1127–1130.
64 Kajinami K, Brousseau ME, Nartsupha C, et al. (2004) ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin. J Lipid Res 45, 653–656.
65 Lecerf JM (2007) Phytosterols and cardiovascular risk. Nutr Clin Metab 21, 17–27.
66 Lakoski SG, Xu F, Vega GL, et al. (2010) Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin. J Clin Endocrinol Metab 95, 800–809.
67 Boucher P, de Lorgeril M, Salen P, et al. (1998) Effect of dietary cholesterol on LDL-receptor, HMGCoA reductase and LRP mRNA expression in healthy humans. Lipids 33, 1177–1186.
68 Shekelle RB, Mac Millan Shryock A, Paul O, et al. (1981) Diet, serum cholesterol and death from CHD – The Western Electric Study. N Engl J Med 304, 65–70.
69 Mc Gee DL, Reed DM, Yano K, et al. (1984) Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Am J Epidemiol 119, 667–676.
70 Stamler JS & Shekelle RB (1988) Dietary cholesterol and human coronary heart disease. Arch Pathol Lab Med 112, 1032–1040.
71 Dawber TR, Nickerson RJ, Brand FN, et al. (1982) Eggs, serum cholesterol and coronary heart disease. Am J Clin Nutr 36, 617–625.
72 Hu FB, Stampfer MJ, Rimm EB, et al. (1999) A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 281, 1387–1394.
73 Djousse L & Gaziano JM (2008) Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study. Am J Clin Nutr 87, 964–969.
74 Qureshi AI, Suri FK, Ahmed S, et al. (2007) Regular egg consumption does not increase the risk of stroke and cardiovascular diseases. Med Sci Monit 13, CR1–CR8.
75 Gyllin GH, Laaksonen DE, Atalay M, et al. (2007) Markers of absorption and synthesis of cholesterol in men with type 1 diabetes. Diabetes Metab Res Rev 23, 372–377.
76 Miettinen TA, Gylling H, Tuominen J, et al. (2004) Low synthesis and high absorption of cholesterol characterize type 1 diabetes. Diabetes Care 27, 53–58.
77 Nakamura Y, Okamura T, Tamaki S, et al. (2004) Egg consumption, serum cholesterol and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged. Am J Clin Nutr 80, 58–63.
78 Nakamura Y, Iso H, Kita Y, et al. (2006) Egg consumption serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based Prospective Study. Br J Nutr 96, 921–928.
79 Ravnskov U, Rosch PJ, Sutter MC, et al. (2006) Should we lower cholesterol as much as possible? BMJ 332, 1330–1332.
80 Okuyama H, Ichikawa Y, Sun Y, et al. (2007) Association of high total cholesterol with coronary heart disease mortality differs among subject populations. Familial hypercholesterolemia as a key concept. World Rev Nutr Diet 96, 19–37.
81 Boucher P, Gotthardt M, Li WP, et al. (2003) LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300, 329–332.
82 Espirito Santo SM, Pires NM, Boesten LS, et al. (2004) Hepatic LRP deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood 103, 3777–3782.