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Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status

  • Cai-Xia Zhang (a1) (a2), Suzanne C. Ho (a1), Yu-Ming Chen (a2), Fang-Yu Lin (a3), Jian-Hua Fu (a4) and Shou-Zhen Cheng (a3)...
Abstract

Few studies have evaluated the relationship between the consumption of dietary folate and one-carbon metabolism-related nutrients and breast cancer risk defined by oestrogen receptor (ER) and progesterone receptor (PR) status. The objective of the present study was to examine the associations between dietary folate, vitamin B6, vitamin B12, and methionine intake and the risk of breast cancer by ER and PR status among Chinese women in Guangdong. A hospital-based case–control study was conducted from June 2007 to August 2008, with 438 cases and 438 age (5-year interval)- and residence (rural/urban)-matched controls. Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview. Unconditional logistic regression models were used to calculate multivariate-adjusted OR and 95 % CI. A significant inverse association was found between dietary folate and vitamin B6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0·32 (95 % CI 0·21, 0·49; Ptrend < 0·001) for dietary folate and 0·46 (95 % CI 0·30, 0·69; Ptrend < 0·001) for vitamin B6. No associations were observed for vitamin B12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status.

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Corresponding author
*Corresponding author: Professor S. C. Ho, fax +852 26026986, email suzanneho@cuhk.edu.hk
References
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1 Ulrich CM (2007) Folate and cancer prevention: a closer look at a complex picture. Am J Clin Nutr 86, 271273.
2 Ziegler RG & Lim U (2007) One-carbon metabolism, colorectal carcinogenesis, chemoprevention – with caution. J Natl Cancer Inst 99, 12141215.
3 Halsted CH, Villanueva JA, Devlin AM, et al. (2002) Metabolic interactions of alcohol and folate. J Nutr 132, 2367S2372S.
4 Larsson SC, Giovannucci E & Wolk A (2007) Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 99, 6476.
5 Adzersen KH, Jess P, Freivogel KW, et al. (2003) Raw and cooked vegetables, fruits, selected micronutrients, and breast cancer risk: a case–control study in Germany. Nutr Cancer 46, 131137.
6 Chou YC, Lee MS, Wu MH, et al. (2007) Plasma homocysteine as a metabolic risk factor for breast cancer: findings from a case–control study in Taiwan. Breast Cancer Res Treat 101, 199205.
7 Graham S, Hellmann R, Marshall J, et al. (1991) Nutritional epidemiology of postmenopausal breast cancer in western New York. Am J Epidemiol 134, 552566.
8 Lajous M, Lazcano-Ponce E, Hernandez-Avila M, et al. (2006) Folate, vitamin B6, and vitamin B12 intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 15, 443448.
9 Levi F, Pasche C, Lucchini F, et al. (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91, 260263.
10 Negri E, La Vecchia C & Franceschi S (2000) Re: dietary folate consumption and breast cancer risk. J Natl Cancer Inst 92, 12701271.
11 Shrubsole MJ, Jin F, Dai Q, et al. (2001) Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Res 61, 71367141.
12 Ronco A, De Stefani E, Boffetta P, et al. (1999) Vegetables, fruits, and related nutrients and risk of breast cancer: a case–control study in Uruguay. Nutr Cancer 35, 111119.
13 Freudenheim JL, Marshall JR, Vena JE, et al. (1996) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst 88, 340348.
14 Baglietto L, English DR, Gertig DM, et al. (2005) Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ 331, 807.
15 Cho E, Spiegelman D, Hunter DJ, et al. (2003) Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 12, 713720.
16 Feigelson HS, Jonas CR, Robertson AS, et al. (2003) Alcohol, folate, methionine, and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 12, 161164.
17 Rohan TE, Jain MG, Howe GR, et al. (2000) Dietary folate consumption and breast cancer risk. J Natl Cancer Inst 92, 266269.
18 Sellers TA, Kushi LH, Cerhan JR, et al. (2001) Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 12, 420428.
19 Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, et al. (2006) Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 83, 895904.
20 Tjønneland A, Christensen J, Olsen A, et al. (2006) Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. Eur J Clin Nutr 60, 280286.
21 Zhang S, Hunter DJ, Hankinson SE, et al. (1999) A prospective study of folate intake and the risk of breast cancer. JAMA 281, 16321637.
22 Larsson SC, Bergkvist L & Wolk A (2008) Folate intake and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Epidemiol Biomarkers Prev 17, 34443449.
23 Maruti SS, Ulrich CM & White E (2009) Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr 89, 624633.
24 Stevens VL, McCullough ML, Sun J, et al. (2010) Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort. Am J Clin Nutr 91, 17081715.
25 Kabat GC, Miller AB, Jain M, et al. (2008) Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer 99, 816821.
26 Ma E, Iwasaki M, Junko I, et al. (2009) Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case–control study in Brazilian women. BMC Cancer 9, 122.
27 Thorand B, Kohlmeier L, Simonsen N, et al. (1998) Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women. Public Health Nutr 1, 147156.
28 Cho E, Holmes M, Hankinson SE, et al. (2007) Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. Cancer Epidemiol Biomarkers Prev 16, 27872790.
29 Chen J, Gammon MD, Chan W, et al. (2005) One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 65, 16061614.
30 Lajous M, Romieu I, Sabia S, et al. (2006) Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes Control 17, 12091213.
31 Lin J, Lee IM, Cook NR, et al. (2008) Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr 87, 734743.
32 Colditz GA, Rosner BA, Chen WY, et al. (2004) Risk factors for breast cancer according to estrogen and progesterone receptor status. J Natl Cancer Inst 96, 218228.
33 Fung TT, Hu FB, Holmes MD, et al. (2005) Dietary patterns and the risk of postmenopausal breast cancer. Int J Cancer 116, 116121.
34 Zhang SM, Hankinson SE, Hunter DJ, et al. (2005) Folate intake and risk of breast cancer characterized by hormone receptor status. Cancer Epidemiol Biomarkers Prev 14, 20042008.
35 Ericson U, Borgquist S, Ivarsson MI, et al. (2010) Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study. J Nutr 140, 16611668.
36 Zhu K, Davidson NE, Hunter S, et al. (2003) Methyl-group dietary intake and risk of breast cancer among African-American women: a case–control study by methylation status of the estrogen receptor alpha genes. Cancer Causes Control 14, 827836.
37 Sellers TA, Vierkant RA, Cerhan JR, et al. (2002) Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women. Cancer Epidemiol Biomarkers Prev 11, 11041107.
38 Ma E, Iwasaki M, Kobayashi M, et al. (2009) Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case–control study in Japan. Nutr Cancer 61, 447456.
39 Zhang CX, Ho SC, Chen YM, et al. (2009) Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women. Int J Cancer 125, 181188.
40 Zhang CX, Ho SC, Chen YM, et al. (2009) Meat and egg consumption and risk of breast cancer among Chinese women. Cancer Causes Control 20, 18451853.
41 Yang YX, He M & Pan XC (2005) China Food Composition 2004. Beijing: Peking University Medical Press.
42 Yang YX, Wang GY & Pan XC (2002) China Food Composition. Beijing: Peking University Medical Press.
43 Zhang CX & Ho SC (2009) Validity and reproducibility of a food frequency questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 18, 240250.
44 Shu XO, Yang G, Jin F, et al. (2004) Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study. Eur J Clin Nutr 58, 1723.
45 Willett WC, Sampson L, Stampfer MJ, et al. (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122, 5165.
46 Willett WC, Howe GR & Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65, 1220S1228S, discussion 1229S–1231S.
47 Potischman N, Swanson CA, Coates RJ, et al. (1999) Intake of food groups and associated micronutrients in relation to risk of early-stage breast cancer. Int J Cancer 82, 315321.
48 Sharp L, Little J, Schofield AC, et al. (2002) Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett 181, 6571.
49 McKillop DJ, Pentieva K, Daly D, et al. (2002) The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet. Br J Nutr 88, 681688.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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