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Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects

Published online by Cambridge University Press:  08 March 2007

Timur Anlasik ,
Helmut Sies ,
Helen R. Griffiths ,
Patrizia Mecocci ,
Wilhelm Stahl  and
M. Cristina Polidori
Timur Anlasik
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
Helmut Sies
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
Helen R. Griffiths
Affiliation:
Life and Health Sciences, Aston University, Birmingham, UK
Patrizia Mecocci
Affiliation:
Institute of Geriatrics and Gerontology, Perugia University Hospital, Perugia, Italy
Wilhelm Stahl
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
M. Cristina Polidori*
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
*
*Corresponding author: Dr M. Cristina Polidori, fax +49 211 81 15 980, email polidori@uni-duesseldorf.de
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Abstract

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Previous studies indicate that regular consumption of a diet rich in fruits and vegetables is associated with a lower risk for age-related diseases. The aim of the present study was to evaluate whether the often-reported age-related decrease of plasma antioxidants in man depends on differences in dietary intake or on other age- and gender-related factors. In this observational case-control study, thirty-nine community-dwelling healthy subjects aged 65 years and older consuming high intakes of fruits and vegetables daily (HI) and forty-eight healthy subjects aged 65 and older consuming low intakes of fruit and vegetables daily (LI) were enrolled. Plasma levels of retinol, tocopherols, carotenoids and malondialdehyde (MDA) as well as content of protein carbonyls in Ig G were measured. Plasma levels of retinol, tocopherols and carotenoids were significantly higher in group HI than in group LI subjects independent of age and gender. MDA levels were inversely correlated with vitamin A and α-carotene. Protein carbonyls were inversely correlated with γ-tocopherol. In the elderly, a higher daily intake of fruits and vegetables is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables. Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life.

Keywords

AgeingAntioxidantsNutritionPrevention
Type
Sort communication
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 639 - 642
Copyright
Copyright © The Nutrition Society 2005

References

Al-Delaimy, WK, Van Kappel, AL & Ferrari, P (2004) Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 7, 713–722.CrossRefGoogle ScholarPubMed
Bazzano, LA, He, J, Ogden, LG, Loria, CM, Vupputuri, S, Myers, L & Whelton, PK (2002) Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clin Nutr 76, 93–99.CrossRefGoogle ScholarPubMed
Brady, WE, Mares-Perlman, JA, Bowen, P & Stacewicz-Sapuntzakis, M (1996) Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J Nutr 126, 129–137.CrossRefGoogle ScholarPubMed
Carty, JL, Bevan, R, Waller, H, Mistry, N, Cooke, M, Lunec, J & Griffiths, HR (2000) The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochem Biophys Res Commun 273, 729–735.CrossRefGoogle ScholarPubMed
Darnton-Hill, I, Nishida, C & James, WPT (2004) A life course approach to diet, nutrition and the prevention of chronic diseases. Public Health Nutr 7, 101–121.CrossRefGoogle ScholarPubMed
Department of Health and Human Services (1988) The Surgeon General's Report on Nutrition and Health. Washington, DC: Department of Health and Human Services, Public Health Service.Google Scholar
Djoussé, L, Arnett, DK, Coon, H, Province, MA, Moore, LL & Ellison, RC (2004) Fruit and vegetable consumption and LDL cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 79, 213–217.CrossRefGoogle ScholarPubMed
Dragsted, LO, Pedersen, A & Hermetter, A (2004) The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. Am J Clin Nutr 79, 1060–1072.CrossRefGoogle ScholarPubMed
Gaziano, JM, Manson, JE, Branch, LG, Colditz, GA, Willett, WC & Buring, JE (1995) A prospective study of consumption of carotenoids in fruit and vegetables and decreased cardiovascular mortality in the elderly. Ann Epidemiol 5, 255–260.CrossRefGoogle ScholarPubMed
Guigoz, Y & Vellas, B (1999) The Mini Nutritional Assessment (MNA) for grading the nutritional state of elderly patients: presentation of the MNA, history and validation. Nestle Nutr Workshop Ser Clin Perform Programme 1, 3–11.CrossRefGoogle ScholarPubMed
John, JH, Ziebland, S, Yudkin, P, Roe, LS & Neil, HA (2002) Oxford Fruit and Vegetable Study Group. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet 359, 1969–1974.CrossRefGoogle Scholar
Joshipura, KJ, Ascherio, A, Manson, JE, Stampfer, MJ, Rimm, EB, Speizer, FE, Hennekens, CH, Spiegelman, D & Willett, WC (1999) Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282, 1233–1239.CrossRefGoogle ScholarPubMed
Joshipura, KJ, Hu, FB & Manson, JE (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 1106–1114.CrossRefGoogle ScholarPubMed
Lampe, JW (1999) Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70, Suppl., 475S–490S.CrossRefGoogle ScholarPubMed
Lasheras, C, Fernandez, S & Patterson, AM (2000) Mediterranean diet and age with respect to overall survival in institutionalized, nonsmoking elderly people. Am J Clin Nutr 71, 987–992.CrossRefGoogle ScholarPubMed
Liu, J, Atamna, H, Kuratsune, H & Ames, BN (2002) Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci 959, 133–166.CrossRefGoogle ScholarPubMed
Liu, S, Lee, IM, Ajani, U, Cole, SR, Buring, JE & Manson, JE (2001) Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: the Physicians’ Health Study. Int J Epidemiol 30, 130–135.CrossRefGoogle Scholar
Liu, S, Manson, JE, Lee, IM, Cole, SR, Hennekens, CH, Willett, WC & Buring, JE (2000) Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr 72, 922–928.CrossRefGoogle ScholarPubMed
Mecocci, P, Polidori, MC & Troiano, L (2000) Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med 28, 1243–1248.CrossRefGoogle Scholar
Mozaffarian, D, Kumanyika, SK, Leimatre, RN, Olson, JL, Burke, GL & Siscovick, DS (2003) Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA 289, 1659–1666.CrossRefGoogle ScholarPubMed
Robertson, RG & Montagnini, M (2004) Geriatric failure to thrive. Am Fam Physician 70, 343–350.Google ScholarPubMed
Stahl, W, Sundquist, AR, Hanusch, M, Schwarz, W & Sies, H (1993) Separation of β-carotene and lycopene geometrical isomers in biological samples. Clin Chem 39, 810–814.CrossRefGoogle ScholarPubMed
Steffen, LM, Jacobs, DR, Stevens, J, Shahar, E, Carithers, T & Folsom, AR (2003) Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 78, 383–390.CrossRefGoogle ScholarPubMed
Tinker, A (2002) The social implications of an ageing population. Mech Aging Dev 123, 729–735.CrossRefGoogle ScholarPubMed
van't Veer, P, Jansen, MC, Klerk, M & Kok, FJ (2000) Fruits and vegetables in the prevention of cancer and cardiovascular disease. Public Health Nutr 3, 103–107.CrossRefGoogle ScholarPubMed
Willett, WC (1994) Diet and health: what should we eat?. Science 254, 532–537.CrossRefGoogle Scholar
Winkler, G, Döring, A (1998) Validation of a short qualitative frequency list used in several German large scale surveys. Eur J Nutr 37, 234–241.Google Scholar
World Health Organization (2002) The World Health Report 2002. Reducing Risks, Promoting Healthy Life. Geneva: WHO.Google Scholar
Yusuf, S, Hawken, S & Ounruu, S (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364, 937–952.CrossRefGoogle ScholarPubMed