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Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract

  • Jonathan J Powell (a1), Vinay Thoree (a1) and Laetitia C Pele (a1)
Abstract

Dietary microparticles are non-biological bacterial-sized particles of the gastrointestinal lumen that occur due to endogenous formation (calcium phosphate) or following oral exposure (exogenous microparticle). In the UK, about 40 mg (1012) of exogenous microparticles are ingested per person per day, through exposure to food additives, pharmaceutical/supplement excipients or toothpaste constituents. Once ingested, exogenous microparticles are unlikely to pass through the gastrointestinal tract without adsorbing to their surfaces some ions and molecules of the intestinal lumen. Both entropy and ionic attraction drive such interactions. Calcium ions are especially well adsorbed by dietary microparticles which then provide a positively charged surface for the attraction (adsorption) of other organic molecules such as lipopolysaccharides, peptidoglycans or protein antigen from the diet or commensal flora. The major (but not only) sites of microparticle entry into intestinal tissue are the M-cell rich lymphoid aggregates (termed Peyer's patches in the small bowel). Indeed, it is well established that this is an efficient transport route for non-biological microparticles although it is unclear why. We hypothesise that this pathway exists for “endogenous microparticles” of calcium phosphate, with immunological and physiological benefit, and that “exogenous dietary microparticles”, such as titanium dioxide and the silicates, hijack this route. This overview focuses on what is known of these microparticles and outlines their potential role in immune tolerance of the gut (endogenous microparticles) or immune activation (exogenous microparticles) and inflammation of the gut.

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Corresponding author
*Corresponding author: Jonathan J. Powell, fax 44 (0) 1223 437515, email jonathan.powell@mrc-hnr.cam.ac.uk
References
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1Lomer MC, Thompson RP & Powell JJ (2002) Fine and ultrafine particles of the diet: influence on the mucosal immune response and association with Crohn's disease. Proc Nutr Soc 61, 123130.
2Lomer MC, Hutchinson C, Volkert S, Greenfield SM, Catterall A, Thompson RP & Powell JJ (2004) Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease. Br J Nutr 92, 947955.
3Powell JJ, Ainley CC, Harvey RS, Mason IM, Kendall MD, Sankey EA, Dhillon AP & Thompson RP (1996) Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. Gut 38, 390395.
4Ellingsen JE (1991) A study on the mechanism of protein adsorption to TiO2. Biomaterials 12, 593596.
5Govers MJ, Termont DS, Van Aken GA & Van der Meer R (1994) Characterization of the adsorption of conjugated and unconjugated bile acids to insoluble, amorphous calcium phosphate. J Lipid Res 35, 741748.
6Lapre JA, De Vries HT, Koeman JH & Van der Meer R (1993) The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat. Cancer Res 53, 784789.
7Van der Meer R, Welberg JW, Kuipers F, Kleibeuker JH, Mulder NH, Termont DS, Vonk RJ, De Vries HT & De Vries EG (1990) Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate, and bile acids. Gastroenterology 99, 16531659.
8Powell JJ, Whitehead MW, Ainley CC, Kendall MD, Nicholson JK & Thompson RP (1999) Dietary minerals in the gastrointestinal tract: hydroxypolymerisation of aluminium is regulated by luminal mucins. J Inorg Biochem 75, 167180.
9Schedl HP, Osbaldiston GW & Mills IH (1968) Absorption, secretion, and precipitation of calcium in the small intestine of the dog. Am J Physiol 214, 814819.
10Favus MJ (1985) Factors that influence absorption and secretion of calcium in the small intestine and colon. Am J Physiol 248, G147G157.
11Sass W, Dreyer HP & Seifert J (1990) Rapid insorption of small particles in the gut. Am J Gastroenterol 85, 255260.
12Sernka TJ & Borle AB (1969) Calcium in the intestinal contents of rats on different calcium diets. Proc Soc Exp Biol Med 131, 14201423.
13Pappo J & Ermak TH (1989) Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake. Clin Exp Immunol 76, 144148.
14Smith MW, Thomas NW, Jenkins PG, Miller NG, Cremaschi D & Porta C (1995) Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats. Exp Physiol 80, 735743.
15Pele L & Powell JJ Microparticles: A link between Modern Life and Inflammatory Bowel Disease (2005) In Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice, 140 ed., pp. 123137 [Colombel JF, Gasche C, Scholmerich J and Vucelic B, editors]. Dordrecht, The Netherlands: Springer.
16Lupton JR, Steinbach G, Chang WC, et al. (1996) Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. J Nutr 126, 14211428.
17Bovee-Oudenhoven IM, Lettink-Wissink ML, Van Doesburg W, Witteman BJ & Van Der Meer R (2003) Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology 125, 469476.
18Bovee-Oudenhoven IM, Termont DS, Weerkamp AH, Faassen-Peters MA & Van der Meer R (1997) Dietary calcium inhibits the intestinal colonization and translocation of Salmonella in rats. Gastroenterology 113, 550557.
19Bovee-Oudenhoven IM, Wissink ML, Wouters JT & Van der Meer R (1999) Dietary calcium phosphate stimulates intestinal lactobacilli and decreases the severity of a salmonella infection in rats. J Nutr 129, 607612.
20Hambly RJ, Saunders M, Rijken PJ & Rowland IR (2002) Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon. Food Chem Toxicol 40, 801808.
21Penman ID, Liang QL, Bode J, Eastwood MA & Arends MJ (2000) Dietary calcium supplementation increases apoptosis in the distal murine colonic epithelium. J Clin Pathol 53, 302307.
22Zhu Y, Mahon BD, Froicu M & Cantorna MT (2005) Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35, 217224.
23Evans SM, Ashwood P, Warley A, Berisha F, Thompson RP & Powell JJ (2002) The role of dietary microparticles and calcium in apoptosis and interleukin-1beta release of intestinal macrophages. Gastroenterology 123, 15431553.
24Ferguson TA, Herndon J, Elzey B, Griffith TS, Schoenberger S & Green DR (2002) Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol 168, 55895595.
25Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K & Steinman RM (2002) Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 196, 10911097.
26Blander JM & Medzhitov R (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808812.
27Smythies LE, Sellers M, Clements RH, Mosteller-Barnum M, Meng G, Benjamin WH, Orenstein JM & Smith PD (2005) Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 115, 6675.
28Shepherd NA, Crocker PR, Smith AP & Levison DA (1987) Exogenous pigment in Peyer's patches. Hum Pathol 18, 5054.
29Urbanski SJ, Arsenault AL, Green FH & Haber G (1989) Pigment resembling atmospheric dust in Peyer's patches. Mod Pathol 2, 222226.
30Mazumder RN, Bode J, McIntyre MM & Ghosh S (2002) Detection of chromium microparticles in inflammatory bowel disease (IBD) tissues by energy dispersive analysis of X-rays. Gut 50, 83A.
31Powell JJ, Harvey RS & Thompson RP (1996) Microparticles in Crohn's disease–has the dust settled? Gut 39, 340341.
32Ashwood P, Thompson RP & Powell JJ (2007) Fine particles that adsorb lipopolysaccharide via bridging calcium cations may mimic bacterial pathogenicity towards cells. Exp Biol Med 232, 107–117.
33Powell JJ, Harvey RS, Ashwood P, Wolstencroft R, Gershwin ME & Thompson RP (2000) Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease. J Autoimmun 14, 99–105.
34Netea MG, Ferwerda G, de Jong DJ, et al. (2005) The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem 280, 3585935867.
35Lomer MC, Harvey RS, Evans SM, Thompson RP & Powell JJ (2001) Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn's disease. Eur J Gastroenterol Hepatol 13, 101–106.
36Lomer MC, Grainger SL, Ede R, et al. (2005) Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn's disease. Eur J Gastroenterol Hepatol 17, 377384.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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