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Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease

  • Miranda C. E. Lomer (a1), Carol Hutchinson (a2), Sara Volkert (a2), Simon M. Greenfield (a3), Adrian Catterall (a4), Richard P. H. Thompson (a1) and Jonathan J. Powell (a1) (a5)...
Abstract

Dietary microparticles are non-biological, bacterial-sized particles. Endogenous sources are derived from intestinal Ca and phosphate secretion. Exogenous sources are mainly titanium dioxide (TiO2) and mixed silicates (Psil); they are resistant to degradation and accumulate in human Peyer's patch macrophages and there is some evidence that they exacerbate inflammation in Crohn's disease (CD). However, whether their intake differs between those with and without CD has not been studied. We aimed to identify dietary microparticle sources and intakes in subjects with and without CD. Patients with inactive CD and matched general practice-based controls (ninety-one per group) completed 7d food diaries. Intake data for dietary fibre and sucrose were compared as positive controls. All foods, pharmaceuticals and toothpastes were examined for microparticle content, and intakes of Ca and exogenous microparticles were compared between the two groups. Dietary intakes were significantly different between cases and controls for dietary fibre (12 (SD 5) v. 14 (sd 5) g/d; P=0.001) and sucrose (52 (sd 27) v. 45 (sd 18) g/d; P=0·04) but not for Ca. Estimated median TiO2 and Psil intakes (2·5 and 35mg/individual per d respectively, totalling 1012–1013 microparticles/individual per d) were broadly similar to per capita estimates and while there was wide variation in intakes between individuals there was no significant difference between subjects with CD and controls. Hence, if exposure to microparticles is associated with the inflammation of CD, then the present study rules out excess intake as the problem. Nonetheless, microparticle-containing foods have now been identified which allows a low-microparticle diet to be further assessed in CD.

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Corresponding author
*Corresponding author: Dr Miranda C. E. Lomer, fax +44 20 7188 2510, email, miranda.lomer@kcl.ac.uk
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SHC Anderson , H Elliott , DJ Wallis , LT Canham & JJ Powell (2003) Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions. Phys Stat Sol 197, 331335.

M Ballegaard , A Bjergstrom , S Brondum , E Hylander , L Jensen & K Ladefoged (1997) Self-reported food intolerance in chronic inflammatory bowel disease. Scand J Gastroenterol 32, 569571.

WE Barhnart , LK Hiller , GJ Leonard & SE Michaels (1974) Dentifrice usage and ingestion among four age groups. J Dental Res 53, 13171322.

S Bengmark (2001) Pre-, pro- and synbiotics. Curr Opin Clin Nutr Metab Care 4, 571579.

SA Bingham , C Gill & A Welch (1997) Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Int J Epidemiol 26, S137S151.

BD Breuer-Katschinski , N Hollander & H Goebell (1996) Effect of cigarette smoking on the course of Crohn's disease. Eur J Gastroenterol Hepatol 8, 225228.

J Cosnes , F Carbonnel , F Carrat , L Beaugerie , S Cattan & J Gendre (1999) Effects of current and former cigarette smoking on the clinical course of Crohn's disease. Aliment Pharmacol Ther 13, 14031411.

RD Ellis , JR Goodlad , GA Limb , JJ Powell , RP Thompson & NA Punchard (1998) Activation of nuclear factor kappa B in Crohn's disease. Inflamm Res 47, 440445.

SM Evans , P Ashwood , A Warley , F Berisha , RP Thompson & JJ Powell (2002) The role of dietary microparticles and calcium in apoptosis and interleukin-1beta release of intestinal macrophages. Gastroenterology 123, 15431553.

MJ Gibney (1999) Dietary intake methods for estimating food additive intake. Regul Toxicol Pharmacol 30, S31S33.

J Hampe , J Grebe & S Nikolaus (2002) Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. Lancet 359, 16611665.

PH Harper , EC Lee , MG Kettlewell , MK Bennett & DP Jewell (1985) Role of the faecal stream in the maintenance of Crohn's colitis. Gut 26, 279284.

N Inohara , Y Ogura & A Fontalba (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278, 55095512.

G Jarnerot , I Jarnmark & K Nilsson (1983) Consumption of refined sugar by patients with Crohn's disease, ulcerative colitis, or irritable bowel syndrome. Scand J Gastroenterol 18, 9991002.

B Katschinski , RF Logan , M Edmond & MJ Langman (1988) Smoking and sugar intake are separate but interactive risk factors in Crohn's disease. Gut 29, 12021206.

M Kovacsovics-Bankowski , K Clark , B Benacerraf & KL Rock (1993) Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A 90, 49424946.

CA Lawrie & NM Rees (1996) The approach adopted in the UK for the estimation of the intake of food additives. Food Addit Contam 13, 411416.

MCE Lomer , RSJ Harvey , SM Evans , RPH Thompson & JJ Powell (2001) Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn's disease. Eur J Gastroenterol Hepatol 13, 101106.

MCE Lomer , RPH Thompson , J Commisso , CL Keen & JJ Powell (2000) Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst 125, 23392343.

MR Lowik (1996) Possible use of food consumption surveys to estimate exposure to additives. Food Addit Contam 13, 427441.

GA Martini & JW Brandes (1976) Increased consumption of refined carbohydrates in patients with Crohn's disease. Klin Wochenschr 54, 367371.

JF Mayberry , J Rhodes , R Allan , RG Newcombe , GM Regan , LM Chamberlain & KG Wragg (1981) Diet in Crohn's disease: two studies of current and previous habits in newly diagnosed patients. Dig Dis Sci 26, 444448.

JJ Powell , CC Ainley , RS Harvey , IM Mason , MD Kendall , EA Sankey , AP Dhillon & RP Thompson (1996) Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue. Gut 38, 390395.

S Reif , I Klein , F Lubin , M Farbstein , A Hallak & T Gilat (1997) Pre-illness dietary factors in inflammatory bowel disease. Gut 40, 754760.

JM Samet , F Dominici , FC Curriero , I Coursac & SL Zeger (2000) Fine particulate air pollution and mortality in 20 U.S. cities, 1987–1994. N Engl J Med 343, 17421749.

NA Shepherd , PR Crocker , AP Smith & DA Levison (1987) Exogenous pigment in Peyer's patches. Hum Pathol 18, 5054.

K Silkoff , A Hallak , L Yegena , P Rozen , JF Mayberry , J Rhodes & RG Newcombe (1980) Consumption of refined carbohydrate by patients with Crohn's disease in Tel-Aviv-Yafo. Postgrad Med J 56, 842846.

SN Sullivan (1990) Hypothesis revisited: toothpaste and the cause of Crohn's disease. Lancet 336, 10961097.

PD Taylor , R Jugdaohsingh & JJ Powell (1997) Soluble silica with high affinity for aluminium under physiological and natural conditions. J Am Chem Soc 119, 88528856.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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