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Different kinds of vegetable oils in relation to individual cardiovascular risk factors among Iranian women

  • Ahmad Esmaillzadeh (a1) (a2) and Leila Azadbakht (a1) (a2)

Abstract

Detrimental effects of trans-fats on lipid profiles, blood pressure and plasma glucose levels have been documented by short-term clinical trials with high doses of trans-fats, but limited observational studies have considered habitual consumption of partially hydrogenated vegetable oil (PHVO) and these outcome variables, particularly hypertension. We aimed to evaluate the association of PHVO and non-hydrogenated vegetable oils (non-HVO) intake with individual cardiovascular risk factors. In a cross-sectional study of 486 Iranian adult women, usual dietary intakes were assessed, and fasting plasma glucose (FPG), lipid profiles and blood pressure were measured. PHVO (commonly used for cooking in Iran) were considered as the PHVO category. Sunflower oil, maize oil, rapeseed oil, soyabean oil and olive oil were defined as the non-HVO category. Diabetes (FPG ≥ 1260 mg/l), dyslipidaemia (based on Adult Treatment Panel III) and hypertension (based on Joint National Committee VI) were defined. The presence of ‘at least one risk factor’ and ‘at least two risk factors’ of the three major risk factors for CVD (hypertension, dyslipidaemia and diabetes) was also evaluated. After controlling for age and other potential confounders, a high consumption of HVO was associated with a greater risk of having dyslipidaemia (OR for top v. bottom quintile 5·04; 95 % CI 2·70, 9·36), hypertension (OR for top v. bottom quintile 3·03; 95 % CI 1·55, 6·10), at least one (OR for top v. bottom quintile 8·52; 95 % CI 4·41, 16·41) and at least two risk factors (OR for top v. bottom quintile 3·60; 95 % CI 1·64, 7·74), while those in the top quintile of non-HVO consumption had lower odds for all these conditions. Further adjustment for dietary intakes had little impact on these associations. Even after additional adjustment for BMI, the positive association of HVO and the inverse association of non-HVO with the above-mentioned cardiovascular risk factors remained significant, except for the association between non-HVO and hypertension that became marginally significant. No overall significant associations were found between the consumption of HVO and non-HVO and diabetes. Higher intakes of PHVO were associated with a greater risk of individual cardiovascular risk factors, while those of non-HVO were associated with a reduced risk.

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Corresponding author

*Corresponding author: A. Esmaillzadeh, fax +98 311 6682509, email esmaillzadeh@hlth.mui.ac.ir

References

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1 Okrainec, K, Banerjee, DK & Eisenberg, MJ (2004) Coronary artery disease in the developing world. Am Heart J 148, 715.
2 Yusuf, S, Hawken, S, Ounpuu, S, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet 364, 937952.
3 Yusuf, S, Reddy, S, Ounpuu, S, et al. (2001) Global burden of cardiovascular diseases: part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation 104, 28552864.
4 Reddy, KS & Yusuf, S (1998) Emerging epidemic of cardiovascular disease in developing countries. Circulation 97, 596601.
5 Mozaffarian, D, Katan, MB, Ascherio, A, et al. (2006) Trans fatty acids and cardiovascular disease. N Engl J Med 354, 16011613.
6 Chardigny, JM, Malpuech-Brugere, C, Dionisi, F, et al. (2006) Rationale and design of the TRANSFACT project phase I: a study to assess the effect of the two different dietary sources of trans fatty acids on cardiovascular risk factors in humans. Contemp Clin Trials 27, 364373.
7 Lichtenstein, AH, Ausman, LM, Jalbert, SM, et al. (1999) Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 340, 19331940.
8 Judd, JT, Baer, DJ, Clevidence, BA, et al. (2002) Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men. Lipids 37, 123131.
9 Oomen, CM, Ocke, MC, Feskens, EJ, et al. (2001) Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet 357, 746751.
10 Pisabarro, RE, Sanguinetti, C, Stoll, M, et al. (2004) High incidence of type 2 diabetes in peroxisome proliferator-activated receptor gamma2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids. Diabetes Care 27, 22512252.
11 Mozaffarian, D, Abdollahi, M, Campos, H, et al. (2007) Consumption of trans-fats and estimated effects on coronary heart disease in Iran. Eur J Clin Nutr 61, 10041010.
12 Asgary, S, Nazari, B, Sarrafzadegan, S, et al. (2009) Fatty acid composition of commercially available Iranian vegetable oils. J Res Med Sci 14, 211215.
13 Azizi, F, Esmaillzadeh, A & Mirmiran, P (2004) Obesity and cardiovascular disease risk factors in Tehran adults: a population-based study. East Mediterr Health J 10, 887897.
14 Esmaillzadeh, A & Azadbakht, L (2008) Food intake patterns may explain the high prevalence of cardiovascular risk factors among Iranian women. J Nutr 138, 14691475.
15 Esmaillzadeh, A & Azadbakht, L (2008) Home use of vegetable oils, markers of systemic inflammation and endothelial dysfunction among women. Am J Clin Nutr 88, 913921.
16 Esmaillzadeh, A & Azadbakht, L (2008) Consumption of hydrogenated versus non-hydrogenated vegetable oils and risk of insulin resistance and the metabolic syndrome among Iranian adult women. Diabetes Care 31, 223226.
17 Esmaillzadeh, A, Kimiagar, M, Mehrabi, Y, et al. (2007) Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am J Clin Nutr 85, 910918.
18 Esmaillzadeh, A, Kimiagar, M, Mehrabi, Y, et al. (2006) Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. Am J Clin Nutr 84, 14891497.
19 Esmaillzadeh, A & Azadbakht, L (2008) Major dietary patterns in relation to general obesity and central adiposity among Iranian women. J Nutr 138, 358363.
20 Ghaffarpour, M, Houshiar-Rad, A & Kianfar, A (1999) The Manual for Household Measures, Cooking Yields Factors and Edible Portion of Foods (in Farsi). Tehran: Keshavarzi Press.
21 Azadbakht, L, Atabak, S & Esmaillzadeh, A (2008) Soy protein intake, cardio-renal indices and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care 3, 648654.
22 Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499502.
23 National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults. Circulation 106, 3143–421.
24 Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (1997) The sixth report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Arch Intern Med 157, 2413–46.
25 Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26, S5S20.
26 Esmaillzadeh, A, Kimiagar, M, Mehrabi, Y, et al. (2007) Dietary patterns and markers of systemic inflammation among Iranian women. J Nutr 137, 992998.
27 Craig, CL, Marshall, AL, Sjostrom, M, et al. (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35, 13811395.
28 Willett, WC (1998) Nutritional Epidemiology, 2nd ed. New York: Oxford University Press.
29 McGandy, RB, Hegsted, DM & Myers, ML (1970) Use of semisynthetic fats in determining effects of specific dietary fatty acids on serum lipids in man. Am J Clin Nutr 23, 12881298.
30 Keys, A, Anderson, JT & Grande, F (1965) Serum cholesterol response to change in the diet. Metabolism 14, 747758.
31 Lichtenstein, AH, Ausman, LM, Carrasco, W, et al. (1993) Hydrogenation impairs the hypolipidemic effect of corn oil in humans: hydrogenation, trans fatty acids, and plasma lipids. Arterioscler Thromb 13, 154161.
32 Micha, R & Mozaffarian, D (2008) Trans fatty acids: effects on cardiometabolic health and implications for policy. Prostaglandins Leukot Essent Fatty Acids 79, 147152.
33 Azadbakht, L & Esmaillzadeh, A (2008) Fast foods and risk of chronic diseases. J Res Med Sci 13, 12.
34 Rastogi, T, Reddy, KS, Vaz, M, et al. (2004) Diet and risk of ischemic heart disease in India. Am J Clin Nutr 79, 582592.
35 Baylin, A, Kabagambe, EK, Ascherio, A, et al. (2003) High 18:2 trans-fatty acids in adipose tissue are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults. J Nutr 133, 11861191.
36 Colón-Ramos, U, Baylin, A & Campos, H (2006) The relation between trans fatty acid levels and increased risk of myocardial infarction does not hold at lower levels of trans fatty acids in the Costa Rican food supply. J Nutr 136, 28872892.
37 Aro, A, Kardinaal, AF, Salminen, I, et al. (1995) Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study. Lancet 345, 273278.
38 Roberts, TL, Wood, DA, Riemersma, RA, et al. (1995) Trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. Lancet 345, 278282.
39 Mozaffarian, D, Aro, A & Willett, WC (2009) Health effects of trans-fatty acids: experimental and observational evidence. Eur J Clin Nutr 63, S5S21.
40 Sun, Q, Ma, J, Campos, H, et al. (2007) A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 115, 18581865.
41 Mozaffarian, D & Clarke, R (2009) Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr 63, S22S33.
42 Grundy, SM & Denke, MA (1990) Dietary influences on serum lipids and lipoproteins. J Lipid Res 31, 11491172.
43 European Food Safety Authority (2004) Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the presence of trans fatty acids in foods and the effect on human health of the consumption of trans fatty acids. EFSA J 81, 149.
44 Roos, NM, Bots, ML & Katan, MB (2001) Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 21, 12331237.
45 van Dam, RM, Rimm, EB, Willett, WC, et al. (2002) Dietary patterns and risk for type 2 diabetes mellitus among US men. Ann Intern Med 136, 201209.
46 Meyer, KA, Kushi, LH, Jacobs, DR Jr, et al. (2001) Dietary fat and incidence of type 2 diabetes in older Iowa women. Diabetes Care 24, 15281535.
47 Hu, FB, Manson, JE, Stampfer, MJ, et al. (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345, 790797.
48 Vega-Lopez, S, Ausman, LM, Jalbert, SM, et al. (2006) Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects. Am J Clin Nutr 84, 5462.
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