Skip to main content
×
Home
    • Aa
    • Aa

Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age

  • Emilie Counil (a1), Pierre Julien (a2), Benoit Lamarche (a3), Marie-Ludivine Château-Degat (a1) (a4), Annie Ferland (a1) and Eric Dewailly (a1)...
Abstract

Dietary exposure to trans-fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living in Nunavik (Québec, Canada). In a cross-sectional, population-based survey, a total of 795 Nunavik Inuit eligible participants gave a blood sample. Exposure to TFA was assessed by their relative proportion in erythrocyte membrane. We performed multiple regression analysis using plasma lipids or their linear combinations as the dependent variables and TFA as the main predictor, adjusting for potential confounders. The associations varied markedly between the sexes and according to age. In men (n 357, aged 36·3 (sd 14·3) years, TFA 1·24 (sd 0·54) %), TFA tended to be negatively associated with HDL-cholesterol (HDL-C), apoA1 and LDL particle size, and positively associated with non-HDL-C, LDL-cholesterol (LDL-C), apoB100, the apoB100:apoA1 ratio and the ratios of total cholesterol (TC), LDL-C and TAG to HDL-C. No such trends were observed in women (n 438, aged 37·0 (sd 14·1) years, TFA 1·16 (sd 0·54) %), except for HDL-C and apoA1 in women aged 50 years and more. These results suggest that TFA could raise the risk of CHD in Inuit men at least through their physiological effects on plasma lipids. The differential associations reported in pre- and postmenopausal women need to be reproduced in other populations and in experimental studies addressing the influence of sex hormones in response to dietary fats.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Emilie Counil, fax +1 418 654 2726, email Emilie.Counil@crchul.ulaval.ca
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1A Ascherio , EB Rimm , EL Giovannucci , (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313, 8490.

2P Pietinen , A Ascherio , P Korhonen , (1997) Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Epidemiol 145, 876887.

3K Oh , FB Hu , JE Manson , (2005) Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses' Health Study. Am J Epidemiol 161, 672679.

4CM Oomen , MC Ocke , EJ Feskens , (2001) Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet 357, 746751.

6T Pars , M Osler & P Bjerregaard (2001) Contemporary use of traditional food among Greenlandic Inuit. Arctic 54, 2231.

9E Searles (2002) Food and the making of Inuit identity. Food Foodways 10, 5578.

12Q Sun , J Ma , H Campos , (2007) A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 115, 18581865.

13EK Kabagambe , MY Tsai , PN Hopkins , (2008) Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study. Clin Chem 54, 154162.

17D Mozaffarian , MB Katan , A Ascherio , (2006) Medical progress – trans fatty acids and cardiovascular disease. N Engl J Med 354, 16011613.

19NA Shaikh & E Downar (1981) Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis. Circ Res 49, 316325.

22AJ Tremblay , H Morrissette , JM Gagne , (2004) Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with β-quantification in a large population. Clin Biochem 37, 785790.

23B Lamarche , A Tchernof , P Mauriege , (1998) Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA 279, 19551961.

24AC St-Pierre , IL Ruel , B Cantin , (2001) Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation 104, 22952299.

25DR Matthews , JP Hosker , AS Rudenski , (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.

26TG Pickering , JE Hall , LJ Appel , (2005) Recommendations for blood pressure measurement in humans: an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee. J Clin Hypertens (Greenwich) 7, 102109.

29J Genest (2008) The Yin and Yang of high-density lipoprotein cholesterol. J Am Coll Cardiol 51, 643644.

30MJ Stampfer , FM Sacks , S Salvini , (1991) A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med 325, 373381.

31RP Mensink & MB Katan (1990) Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 323, 439445.

33AH Lichtenstein , LM Ausman , SM Jalbert , (1999) Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 340, 19331940.

34NR Matthan , FK Welty , PH Barrett , (2004) Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women. Arterioscler Thromb Vasc Biol 24, 10921097.

36SH Mitmesser & TP Carr (2005) Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells. J Nutr Biochem 16, 178183.

37KK Berneis & RM Krauss (2002) Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res 43, 13631379.

38FM Sacks & H Campos (2003) Clinical review 163. Cardiovascular endocrinology: low-density lipoprotein size and cardiovascular disease: a reappraisal. J Clin Endocrinol Metab 88, 45254532.

41J Dyerberg , DC Eskesen , PW Andersen , (2004) Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur J Clin Nutr 58, 10621070.

42JE Roeters van Lennep , HT Westerveld , DW Erkelens , (2002) Risk factors for coronary heart disease: implications of gender. Cardiovasc Res 53, 538549.

45RH Knopp , P Paramsothy , BM Retzlaff , (2006) Sex differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease. Curr Cardiol Rep 8, 452459.

47A Lapointe , EM Balk & AH Lichtenstein (2006) Gender differences in plasma lipid response to dietary fat. Nutr Rev 64, 234249.

48GR Cooper , GL Myers , SJ Smith , (1992) Blood lipid measurements. Variations and practical utility. JAMA 267, 16521660.

49MA Pereira , AI Kartashov , CB Ebbeling , (2005) Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis. Lancet 365, 3642.

50FB Hu , TY Li , GA Colditz , (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289, 17851791.

51American Diabetes Association (2008) Standards of medical care in diabetes – 2008. Diabetes Care 31, Suppl. 1, S12S54.

52AV Chobanian , GL Bakris , HR Black , (2003) Seventh report of the Joint National Committee on Prevention. Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42, 12061252.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: