Skip to main content
×
Home
    • Aa
    • Aa

Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations

  • Tri Vuong (a1) (a2) (a3), Chantal Matar (a2) (a3), Charles Ramassamy (a2) (a4) and Pierre S. Haddad (a1) (a2)
Abstract

A growing body of evidence supports the therapeutic effects of blueberry in neurodegenerative disorders. Biotransformation of blueberry juice by Serratia vaccinii bacteria increases its phenolic content and antioxidant activity. In neuronal cell culture, biotransformed blueberry juice (BJ) significantly increased the activity of antioxidant enzymes, namely catalase and superoxide dismutase. Moreover, BJ protected neurons against H2O2-induced cell death in a dose-dependent manner. This associated with the upregulation of mitogen-activated protein kinase (MAPK) family enzymes p38 and c-Jun N-terminal kinase (JNK) activation, as well as with the protection of extracellular signal-regulated kinase (ERK1/2) and MAPK/ERK kinase (MEK1/2) activity loss induced by H2O2. The present studies demonstrate that BJ can protect neurons against oxidative stress possibly by increasing antioxidant enzyme activities and activating p38- and JNK-dependent survival pathways while blocking MEK1/2- and ERK1/2-mediated cell death. Thus, BJ may represent a novel approach to prevent and to treat neurodegenerative disorders, and it may represent a source of novel therapeutic agents against these diseases.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Pierre S. Haddad, fax +1 514 343 2291, email pierre.haddad@umontreal.ca
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1N Le Forestier , L Lacomblez & V Meininger (2008) Parkinson disease and amyotrophic lateral sclerosis. Tauopathies, TDP-43 and SOD mutations. Rev Neurol (Paris) 165, 1530.

2M Mancuso , D Orsucci , G Siciliano , (2008) Mitochondria, mitochondrial DNA and Alzheimer's disease. What comes first? Curr Alzheimer Res 5, 457468.

3D Pratico (2008) Oxidative stress hypothesis in Alzheimer's disease: a reappraisal. Trends Pharmacol Sci 29, 609615.

4TA Yacoubian & DG Standaert (2008) Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta 1792, 676687.

5DW Busija , T Gaspar , F Domoki , (2008) Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: mitochondrial targeted preconditioning. Adv Drug Deliv Rev 60, 14711477.

6J Cadet , T Douki & JL Ravanat (2008) Oxidatively generated damage to the guanine moiety of DNA: mechanistic aspects and formation in cells. Acc Chem Res 41, 10751083.

7HJ Heo , SJ Choi , SG Choi , (2008) Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells. J Food Sci 73, H28H32.

8JG Pizarro , M Yeste-Velasco , V Rimbau , (2008) Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci 26, 269276.

9LX Yang , LJ Zhang , KX Huang , (2008) Antioxidant and neuroprotective effects of synthesized sintenin derivatives. J Enzyme Inhib Med Chem 24, 425431.

10M Valko , D Leibfritz , J Moncol , (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39, 4484.

11J Lindenau , H Noack , H Possel , (2000) Cellular distribution of superoxide dismutases in the rat CNS. Glia 29, 2534.

12LO Murphy & J Blenis (2006) MAPK signal specificity: the right place at the right time. Trends Biochem Sci 31, 268275.

13M Krishna & H Narang (2008) The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 65, 35253544.

14JA Joseph , B Shukitt-Hale & FC Lau (2007) Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann N Y Acad Sci 1100, 470485.

17B Shukitt-Hale , AN Carey , D Jenkins , (2007) Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 28, 11871194.

18C Ramassamy (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545, 5164.

19M Singh , M Arseneault , T Sanderson , (2008) Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms. J Agric Food Chem 56, 48554873.

20JY Wang , LL Wen , YN Huang , (2006) Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharm Des 12, 35213533.

21KL Wolfe , X Kang , X He , (2008) Cellular antioxidant activity of common fruits. J Agric Food Chem 56, 84188426.

22KB Duffy , EL Spangler , BD Devan , (2008) A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29, 16801689.

23B Shukitt-Hale , FC Lau , AN Carey , (2008) Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci 11, 172182.

24SO McGuire , CE Sortwell , B Shukitt-Hale , (2006) Dietary supplementation with blueberry kextract improves survival of transplanted dopamine neurons. Nutr Neurosci 9, 251258.

25FC Lau , DF Bielinski & JA Joseph (2007) Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res 85, 10101017.

26L Martin & C Matar (2005) Increase of antioxidant capacity of the lowbush blueberry (Vaccinium angustifolium) during fermentation by a novel bacterium from the fruit microflora. J Sci Food Agric 85, 14771484.

27T Vuong , L Martin & C Matar (2006) Antioxidant activity of fermented berry juices and their effects on nitric oxide and tumor necrosis factor-alpha production in macrophage 264.7 gamma NO( − ) cell line. J Food Biochem 30, 249268.

28T Vuong , LC Martineau , C Ramassamy , (2007) Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharmacol 85, 956965.

29T Vuong , A Benhaddou-Andaloussi , A Brault , (2009) Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA(y) mice. Int J Obes (Lond) 33, 11661173.

30MD Matchett , SL MacKinnon , MI Sweeney , (2006) Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J Nutr Biochem 17, 117125.

31AY Sun , Q Wang , A Simonyi , (2008) Botanical phenolics and brain health. Neuromol Med 10, 259274.

32NP Seeram , M Aviram , Y Zhang , (2008) Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 56, 14151422.

34S Fourquet , ME Huang , B D'Autreaux , (2008) The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling. Antioxid Redox Signal 10, 15651576.

35ER Whittemore , DT Loo , JA Watt , (1995) A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience 67, 921932.

36G Filiz , A Caragounis , L Bica , (2008) Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity. Int J Biochem Cell Biol 40, 10301042.

37U Kemmerling , P Munoz , M Muller , (2007) Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons. Cell Calcium 41, 491502.

39JS Ditelberg , RA Sheldon , CJ Epstein , (1996) Brain injury after perinatal hypoxia–ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice. Pediatr Res 39, 204208.

40P Mahakunakorn , M Tohda , Y Murakami , (2005) Effects of Choto-san and its related constituents on endogenous antioxidant systems. Biol Pharm Bull 28, 5357.

41L Amazzal , A Lapotre , F Quignon , (2007) Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells. Neurosci Lett 418, 159164.

42SR Kim , MJ Park , MK Lee , (2002) Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. Free Radic Biol Med 32, 596604.

43XJ Wu , YJ Zheng , YY Cui , (2007) Propofol attenuates oxidative stress-induced PC12 cell injury via p38 MAP kinase dependent pathway. Acta Pharmacol Sin 28, 11231128.

44R Colognato , I Laurenza , I Fontana , (2006) Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr 25, 135145.

45CJ Caunt , SP Armstrong , CA Rivers , (2008) Spatiotemporal regulation of ERK2 by dual specificity phosphatases. J Biol Chem 283, 2661226623.

46RT Nitta , AH Chu & AJ Wong (2008) Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation. J Biol Chem 283, 3493534945.

47D Gutierrez-Sanmartin , E Varela-Ledo , A Aguilera , (2008) Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+T-cell infection with human immunodeficiency virus type I. J Gen Virol 89, 16611671.

48T Lin , NK Mak & MS Yang (2008) MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxicology 247, 145153.

50EK Schroeder , NA Kelsey , J Doyle , (2008) Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective anti-apoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal 11, 469480.

51B Halliwell (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476, 107112.

52B Halliwell (2007) Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc Res 73, 341347.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: