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Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study

Abstract

Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on attention and memory; however, effects in human subjects have not been well studied. The aim of the present study was to examine the association between plasma concentrations of free choline and its related metabolites in children and their neurodevelopment in the Seychelles Child Development Nutrition Study, an ongoing longitudinal study assessing the development of children born to mothers with high fish consumption during pregnancy. Plasma concentrations of free choline, betaine, dimethylglycine (DMG), methionine and homocysteine and specific measures of neurodevelopment were measured in 210 children aged 5 years. The children's plasma free choline concentration (9·17 (sd 2·09) μmol/l) was moderately, but significantly, correlated with betaine (r 0·24; P= 0·0006), DMG (r 0·15; P= 0·03), methionine (r 0·24; P= 0·0005) and homocysteine (r 0·19; P= 0·006) concentrations. Adjusted multiple linear regression revealed that betaine concentrations were positively associated with Preschool Language Scale – total language scores (β = 0·066; P= 0·04), but no other associations were evident. We found no indication that free choline concentration or its metabolites, within the normal physiological range, are associated with neurodevelopmental outcomes in children at 5 years of age. As there is considerable animal evidence suggesting that choline status during development is associated with cognitive outcome, the issue deserves further study in other cohorts.

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Corresponding author
*Corresponding author: Professor J. J. Strain, fax +44 28 7012 3023, email jj.strain@ulster.ac.uk
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1PM Ueland (2011) Choline and betaine in health and disease. J Inherit Metab Dis 34, 315.

4JK Blusztajn , M Liscovitch & UI Richardson (1987) Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line. Proc Natl Acad Sci U S A 84, 54745477.

5SH Zeisel & KA da Costa (2009) Choline: an essential nutrient for public health. Nutr Rev 67, 615623.

7JC McCann , M Hudes & BN Ames (2006) An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring. Neurosci Biobehav Rev 30, 696712.

8CD Albright , MH Mar , CB Friedrich , et al. (2001) Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus. Dev Neurosci 23, 100106.

9CD Albright , AY Tsai , MH Mar , et al. (1998) Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain. Neurochem Res 23, 751758.

10SJ Wong-Goodrich , MJ Glenn , TJ Mellott , et al. (2008) Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. Brain Res 1237, 153166.

12S Grantham-McGregor , YB Cheung , S Cueto , et al. (2007) Developmental potential in the first 5 years for children in developing countries. Lancet 369, 6070.

14SH Ryan , JK Williams & JD Thomas (2008) Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration. Brain Res 1237, 91100.

15BC Ward , NH Kolodny , N Nag , et al. (2009) Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation. J Neurochem 108, 361371.

16SH Zeisel (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. J Pediatr 149, S131S136.

18BTF Wu , RA Dyer , DJ King , et al. (2012) Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. PLoS One 7, e43448.

19FJ Rosales , JS Reznick & SH Zeisel (2009) Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers. Nutr Neurosci 12, 190202.

20A Busche , A Bagorda , K Lehmann , et al. (2006) The maturation of the acetylcholine system in the dentate gyrus of gerbils (Meriones unguiculatus) is affected by epigenetic factors. J Neural Transm 113, 113124.

21JD Sweatt (2010) Neuroscience. Epigenetics and cognitive aging. Science 328, 701702.

22TL Roth , ED Roth & JD Sweatt (2010) Epigenetic regulation of genes in learning and memory. Essays Biochem 48, 263274.

24M de Onis , AW Onyango , E Borghi , et al. (2007) Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85, 660667.

28PI Holm , PM Ueland , G Kvalheim , et al. (2003) Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 49, 286294.

29PW Davidson , GJ Myers , C Cox , et al. (1998) Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA 280, 701707.

30TW Chew , X Jiang , J Yan , et al. (2011) Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice. J Nutr 141, 14751481.

31S Weisberg (2005) Applied Linear Regression. New York, NY: Wiley.

32JJ Strain , PW Davidson , SW Thurston , et al. (2012) Maternal PUFA status but not prenatal methylmercury exposure is associated with children's language functions at age five years in the Seychelles. J Nutr 142, 19431949.

34TV Perneger (1998) What's wrong with Bonferroni adjustments? BMJ 316, 12361238.

35N Nag & JE Berger-Sweeney (2007) Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome. Neurobiol Dis 26, 473480.

36WH Meck , RA Smith & CL Williams (1988) Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory. Dev Psychobiol 21, 339353.

37RK Cheng , CJ MacDonald , CL Williams , et al. (2008) Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior. Learn Mem 15, 153162.

38SJ Eussen , PM Ueland , R Clarke , et al. (2007) The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people. Br J Nutr 98, 960968.

39EY Shen , KH Wu , MF Lin , et al. (2010) Study of brain growth in children – a new approach to volume measurements using MRI-reconstructed 3D neuroimaging. Childs Nerv Syst 26, 16191623.

40J Dobbing & J Sands (1973) Quantitative growth and development of human brain. Arch Dis Child 48, 757767.

41FJ Rosales & SH Zeisel (2008) Perspectives from the symposium: the role of nutrition in infant and toddler brain and behavioral development. Nutr Neurosci 11, 135143.

42J Klein , A Koppen , K Loffelholz , et al. (1992) Uptake and metabolism of choline by rat brain after acute choline administration. J Neurochem 58, 870876.

43SH Zeisel (2004) Nutritional importance of choline for brain development. J Am Coll Nutr 23, 621S626S.

44F Amenta & SK Tayebati (2008) Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction. Curr Med Chem 15, 488498.

45SM Innis , AG Davidson , BN Bay , et al. (2011) Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis. Am J Clin Nutr 93, 564568.


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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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