1Soleas, GJ, Diamandis, EP & Goldberg, DM (1997) Resveratrol: a molecule whose time has come? And gone? Clin Biochem 30, 91–113.
2Gonzalez-Barrio, R, Beltran, D, Cantos, E, Gil, MI, Espin, JC & Tomas-Barberan, FA (2006) Comparison of ozone and UV-C treatments on the postharvest stilbenoid monomer, dimer, and trimer induction in var. ‘Superior’ white table grapes. J Agric Food Chem 54, 4222–4228.
3Romero-Perez, AI, Lamuela-Raventos, RM, Andres-Lacueva, C & Torre-Boronat, MC (2001) Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content. J Agric Food Chem 49, 210–215.
4Burns, J, Yokota, T, Ashihara, H, Lean, ME & Crozier, A (2002) Plant foods and herbal sources of resveratrol. J Agric Food Chem 50, 3337–3340.
5Rimando, AM, Kalt, W, Magee, JB, Dewey, J & Ballington, JR (2004) Resveratrol, pterostilbene, and piceatannol in Vaccinium berries. J Agric Food Chem 52, 4713–4719.
6Sobolev, VS & Cole, RJ (1999) Trans-resveratrol content in commercial peanuts and peanut products. J Agric Food Chem 47, 1435–1439.
7Tokusoglu, O, Unal, MK & Yemis, F (2005) Determination of the phytoalexin resveratrol (3,5,4′-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem 53, 5003–5009.
8Ragab, AS, Van, FJ, Jankowski, B, Park, JH & Bobzin, SC (2006) Detection and quantitation of resveratrol in tomato fruit (Lycopersicon esculentum Mill.). J Agric Food Chem 54, 7175–7179.
9Cantos, E, Espin, JC & Tomas-Barberan, FA (2002) Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. J Agric Food Chem 50, 5691–5696.
10Lamuela-Raventós, R, Romero-Pérez, A, Waterhouse, A & de la Torre-Boronat, M (1995) Direct HPLC analysis of cis- and trans-resveratrol and piceic isomers in Spanish red Vitis vinifera wines. J Agric Food Chem 43, 281–283.
11Romero Perez, AI, Lamuela Raventos, RM, Waterhouse, AL & de la Torre Boronat, MC (1996) Levels of cis- and trans-resveratrol and their glucosides in white and rosé Vitis vinifera wines from Spain. J Agric Food Chem 44, 2124–2128.
12Vitrac, X, Bornet, A, Vanderlinde, R, Valls, J, Richard, T, Delaunay, JC, Merillon, JM & Teissedre, PL (2005) Determination of stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, ɛ-viniferin) in Brazilian wines. J Agric Food Chem 53, 5664–5669.
13Landrault, N, Larronde, F, Delaunay, J, Castagnino, C, Vercauteren, J, Mérillon, J, Gasc, F, Cros, G & Teissedre, P (2002) Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development. J Agric Food Chem 50, 2046–2052.
14Delmas, D, Lancon, A, Colin, D, Jannin, B & Latruffe, N (2006) Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 7, 423–442.
15Signorelli, P & Ghidoni, R (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 16, 449–466.
16Dore, S (2005) Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity. Neurosignals 14, 61–70.
17Fremont, L (2000) Biological effects of resveratrol. Life Sci 66, 663–673.
18Olas, B & Wachowicz, B (2005) Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets 16, 251–260.
19Juan, ME, Gonzalez-Pons, E, Munuera, T, Ballester, J, Rodriguez-Gil, JE & Planas, JM (2005) trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr 135, 757–760.
20Baur, JA & Sinclair, DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5, 493–506.
21Ingram, DK, Zhu, M, Mamczarz, J, Zou, S, Lane, MA, Roth, GS & deCabo, R (2006) Calorie restriction mimetics: an emerging research field. Aging Cell 5, 97–108.
22Baur, JA, Pearson, KJ, Price, NL, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337–342.
23Delmas, D, Jannin, B & Latruffe, N (2005) Resveratrol: preventing properties against vascular alterations and ageing. Mol Nutr Food Res 49, 377–395.
24Orallo, F (2006) Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Curr Med Chem 13, 87–98.
25Goldberg, DM, Yan, J & Soleas, GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36, 79–87.
26Meng, X, Maliakal, P, Lu, H, Lee, MJ & Yang, CS (2004) Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 52, 935–942.
27Soleas, GJ, Yan, J & Goldberg, DM (2001) Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr B Biomed Sci Appl 757, 161–172.
28Urpi-Sarda, M, Jauregui, O, Lamuela-Raventos, RM, Jaeger, W, Miksits, M, Covas, M & Andres-Lacueva, C (2005) Uptake of diet resveratrol into the human low density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Anal Chem 77, 3149–3155.
29Vitaglione, P, Sforza, S, Galaverna, G, Ghidini, C, Caporaso, N, Vescovi, PP, Fogliano, V & Marchelli, R (2005) Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res 49, 495–504.
30Walle, T, Hsieh, F, DeLegge, MH, Oatis, JE & Walle, UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 1377–1382.
31Yu, C, Shin, YG, Chow, A, Li, Y, Kosmeder, JW, Lee, YS, Hirschelman, WH, Pezzuto, JM, Mehta, RG & van Breemen, RB (2002) Human, rat, and mouse metabolism of resveratrol. Pharm Res 19, 1907–1914.
32Zamora-Ros, R, Urpi-Sarda, M, Lamuela-Raventos, RM, Estruch, R, Vazquez-Agell, M, Serrano-Martinez, M, Jaeger, W & Andres-Lacueva, C (2006) Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin Chem 52, 1373–1380.
33Koga, T & Meydani, M (2001) Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr 73, 941–948.
34Moon, JH, Tsushida, T, Nakahara, K & Terao, J (2001) Identification of quercetin 3-O-β-d-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30, 1274–1285.
35Boocock, DJ, Patel, KR, Faust, GES, Normolle, DP, Marczylo, TH, Crowell, JA, Brenner, DE, Booth, TD, Gescher, A & Steward, WP (2007) Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 848, 182–187.
36Gonzalez, CA, Navarro, C, Martinez, C, et al. (2004) The European Prospective Investigation into Cancer and Nutrition (EPIC) (article in Spanish). Rev Esp Salud Publica 78, 167–176.
37Anonymous (1997) Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. EPIC Group of Spain. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26, Suppl. 1, S91–S99.
38Anonymous (1997) Relative validity and reproducibility of a diet history questionnaire in Spain. II. Nutrients. EPIC Group of Spain. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26, Suppl. 1, S100–S109.
39Moller, A, Rhodes, M, Preece, R, Walker, A, Atkins, D, Bailey, G, van Klaveren, J & Vittozzi, L (1998) http://www.foodcomp.dk/basis/ (accessed 15 December 2006).
40Trela, BC & Waterhouse, AL (1996) Resveratrol: isomeric molar absorptivities and stability. J Agric Food Chem 44, 1253–1257.
41Ministerio de Agricultura Pesca y Alimentación (2004) La Alimentación en España. 2003 (Food in Spain.2003). Madrid: Ministerio de Agricultura Pesca y Alimentación.
42Instituto Nacional de Estadística (2005) http://www.ine.es (accessed 15 December 2006).
43Flanders, WD, DerSimonian, R & Freedman, DS (1992) Interpretation of linear regression models that include transformations or interaction terms. Ann Epidemiol 2, 735–744.
44R Development Core Team (2006) A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
45Alarcón de la Lastra, C & Villegas, I (2005) Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 49, 405–430.
46Moreno-Labanda, J, Mallavia, R, Pérez-Fons, L, Lizama, V, Saura, D & Micol, V (2004) Determination of piceid and resveratrol in Spanish wines deriving from Monastrell (Vitis vinifera L.) grape variety. J Agric Food Chem 52, 5396–5403.
47Lee, S, Lee, S, Kim, M, Chun, J, Cheong, Y & Lee, J (2004) Analysis of trans-resveratrol in peanuts and peanut butters consumed in Korea. Food Res Intern 37, 247–251.
48Nicoletti, I, De Rossi, A, Giovinazzo, G & Corradini, D (2007) Identification and quantification of stilbenes in fruits of transgenic tomato plants (Lycopersicon esculentum Mill.) by reversed phase HPLC with photodiode array and mass spectrometry detection. J Agric Food Chem 55, 3304–3311.
49Sieri, S, Agudo, A, Kesse, E, et al. (2002) Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project. Public Health Nutr 5, 1287–1296.
50Guallar-Castillón, P, Rodríguez-Artalejo, F, Díez-Gañan, L, Banegas Banegas, JR, Lafuente Urdionguio, P & Herruzo Cabrera, R (2001) Consumption of alcoholic beverages and subjective health in Spain. J Epidemiol Community Health 55, 648–652.
51Marques-Vidal, P & Dias, CM (2005) Trends and determinants of alcohol consumption in Portugal: results from the national health surveys 1995 to 1996 and 1998 to 1999. Alcohol Clin Exp Res 29, 89–97.
52Levi, F, Pasche, C, Lucchini, F, Ghidoni, R, Ferraroni, M & La Vecchia, C (2005) Resveratrol and breast cancer risk. Eur J Cancer Prev 14, 139–142.
53Kuhnle, G, Spencer, JPE, Chowrimootoo, G, Schroeter, H, Debnam, ES, Srai, SKS, Rice-Evans, C & Hahn, U (2000) Resveratrol is absorbed in the small intestine as resveratrol glucuronide. Biochem Biophys Res Commun 272, 212–217.
54Henry-Vitrac, C, Desmouliere, A, Girand, D, Merillon, JM & Krisa, S (2006) Transport, deglycosilation, and metabolism of trans-piceid by small intestinal epithelial cells. Eur J Nutr 45, 376–382.
55Potischman, N (2003) Biologic and methodologic issues for nutritional biomarkers. J Nutr 133, Suppl. 3, 875S–880S.
56Kelemen, LE (2006) Food frequency questionnaires: not irrelevant yet. Cancer Epidemiol Biomarkers Prev 15, 1054.
57Szmitko, PE & Verma, S (2005) Cardiology patient pages. Red wine and your heart. Circulation 111, e10–e11.
58Aranceta, J, Perez, C, Eguileor, I, Gonzalez de Goldeano, J, Mataix, J & Saez de Burauga, J (1990) .
59Mataix, J, Llopis, J, Martinez de Victoria, E, Montellano, MA, Lopez, M & Aranda, P (1999) Evaluation of the Nutritional Status in the Autonomous Community of Andalucia. Granada, Spain: Public Health Service and Institute of Nutrition and Food Technology of the University of Granada.
60Goldberg, DM, Karumanchiri, A, Ng, E, Yan, J, Diamandis, EP & Soleas, GJ (1995) Direct gas-chromatographic mass-spectrometric method to assay cis-resveratrol in wines – preliminary survey of its concentration in commercial wines. J Agric Food Chem 43, 1245–1250.
61Rodriguez-Delgado, M, González, G, Pérez-Trujillo, J & García-Montelongo, F (2002) Trans-resveratrol in wines from the Canary Islands (Spain). Analysis by high performance liquid chromatography. Food Chem 76, 371–375.
62Álvarez-Sala, L, Slowing-Barrillas, K, Gómez-Serranillos, P, Torres-Segovia, F, Valderrama-Rojas, M & Millán-Núñez, J (2000) Variabilidad del contenido de polifenoles de distintos tipos de vino y su potencial aplicación al conocimiento de sus efectos biológicos (Variability of the content of polyphenols of different types from wine and potential application from the knowledge of their biological effects). Med Clin (Barc) 114, 331–332.
63Martinez-Ortega, MV, Carcia-Parrilla, MC & Troncoso, AM (2000) Resveratrol content in wines and musts from the south of Spain. Nahrung 44, 253–256.
64Andres-Lacueva, C, Ibern-Gomez, M, Lamuela-Raventos, RM, Buxaderas, S & de la Torre-Boronat, M (2002) Cinnamates and resveratrol content for sparkling wine characterization. Am J Enol Vitic 53, 147–150.
65Pozo-Bayon, MA, Hernandez, MT, Martin-Alvarez, PJ & Polo, MC (2003) Study of low molecular weight phenolic compounds during the aging of sparkling wines manufactured with red and white grape varieties. J Agric Food Chem 51, 2089–2095.
66de Lima, M, Waffo-Téguo, P, Teissedre, P, Pujolas, A, Vercauteren, J, Cabanis, J & Mérillon, J (1999) Determination of stilbenes (trans-astringin, cis- and trans-piceid, and cis- and trans-resveratrol) in Portuguese wines. J Agric Food Chem 47, 2666–2670.
67Goldberg, DM, Yan, J, Ng, E, Diamandis, EP, Karumanchiri, A, Soleas, G & Waterhouse, AL (1995) A global survey of trans-resveratrol concentrations in commercial wines. Am J Enol Vitic 46, 159–165.
68Cantos, E, Espin, JC & Tomas-Barberan, FA (2002) Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses. J Agric Food Chem 50, 6322–6329.
69Cantos, E, Tomas-Barberan, FA, Martinez, A & Espin, JC (2003) Differential stilbene induction susceptibility of seven red wine grape varieties upon post-harvest UV-C irradiation. Eur Food Res Technol 217, 253–258.
70Vinas, P, Lopez-Erroz, C, Marin-Hernandez, JJ & Hernandez-Cordoba, M (2000) Determination of phenols in wines by liquid chromatography with photodiode array and fluorescence detection. J Chromatogr A 871, 85–93.
71Roldan, A, Palacios, V, Caro, I & Perez, L (2003) Resveratrol content of Palomino fino grapes: influence of vintage and fungal infection. J Agric Food Chem 51, 1464–1468.
72Romero-Perez, AI, Ibern-Gomez, M, Lamuela-Raventos, RM & Torre-Boronat, MC (1999) Piceid, the major resveratrol derivative in grape juices. J Agric Food Chem 47, 1533–1536.
73Ibern-Gomez, M, Roig-Pérez, S, Lamuela-Raventos, RM & de la Torre-Boronat, M (2000) Resveratrol and piceid levels in natural and blended peanut butters. J Agric Food Chem 48, 6352–6354.
74Zhang, K & Zuo, YG (2004) GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem 52, 222–227.
75Lyons, MM, Yu, C, Toma, RB, Cho, SY, Reiboldt, W, Lee, J & van Breemen, RB (2003) Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 51, 5867–5870.