Skip to main content
×
×
Home

Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort

  • Raul Zamora-Ros (a1), Cristina Andres-Lacueva (a1), Rosa M. Lamuela-Raventós (a1), Toni Berenguer (a2), Paula Jakszyn (a2), Carmen Martínez (a3), María J. Sánchez (a3), Carmen Navarro (a4), María D. Chirlaque (a4), María-José Tormo (a4), Jose R. Quirós (a5), Pilar Amiano (a6), Miren Dorronsoro (a6), Nerea Larrañaga (a6), Aurelio Barricarte (a7), Eva Ardanaz (a7) and Carlos A. González (a2)...
Abstract

Resveratrol has been shown to have beneficial effects on diseases related to oxidant and/or inflammatory processes and extends the lifespan of simple organisms including rodents. The objective of the present study was to estimate the dietary intake of resveratrol and piceid (R&P) present in foods, and to identify the principal dietary sources of these compounds in the Spanish adult population. For this purpose, a food composition database (FCDB) of R&P in Spanish foods was compiled. The study included 40 685 subjects aged 35–64 years from northern and southern regions of Spain who were included in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. Usual food intake was assessed by personal interviews using a computerised version of a validated diet history method. An FCDB with 160 items was compiled. The estimated median and mean of R&P intake were 100 and 933 μg/d respectively. Approximately, 32 % of the population did not consume R&P. The most abundant of the four stilbenes studied was trans-piceid (53·6 %), followed by trans-resveratrol (20·9 %), cis-piceid (19·3 %) and cis-resveratrol (6·2 %). The most important source of R&P was wines (98·4 %) and grape and grape juices (1·6 %), whereas peanuts, pistachios and berries contributed to less than 0·01 %. For this reason the pattern of intake of R&P was similar to the wine pattern. This is the first time that R&P intake has been estimated in a Mediterranean country.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Cristina Andrés-Lacueva, fax +34 93 403 59 31, email candres@ub.edu
References
Hide All
1Soleas, GJ, Diamandis, EP & Goldberg, DM (1997) Resveratrol: a molecule whose time has come? And gone? Clin Biochem 30, 91113.
2Gonzalez-Barrio, R, Beltran, D, Cantos, E, Gil, MI, Espin, JC & Tomas-Barberan, FA (2006) Comparison of ozone and UV-C treatments on the postharvest stilbenoid monomer, dimer, and trimer induction in var. ‘Superior’ white table grapes. J Agric Food Chem 54, 42224228.
3Romero-Perez, AI, Lamuela-Raventos, RM, Andres-Lacueva, C & Torre-Boronat, MC (2001) Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content. J Agric Food Chem 49, 210215.
4Burns, J, Yokota, T, Ashihara, H, Lean, ME & Crozier, A (2002) Plant foods and herbal sources of resveratrol. J Agric Food Chem 50, 33373340.
5Rimando, AM, Kalt, W, Magee, JB, Dewey, J & Ballington, JR (2004) Resveratrol, pterostilbene, and piceatannol in Vaccinium berries. J Agric Food Chem 52, 47134719.
6Sobolev, VS & Cole, RJ (1999) Trans-resveratrol content in commercial peanuts and peanut products. J Agric Food Chem 47, 14351439.
7Tokusoglu, O, Unal, MK & Yemis, F (2005) Determination of the phytoalexin resveratrol (3,5,4′-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS). J Agric Food Chem 53, 50035009.
8Ragab, AS, Van, FJ, Jankowski, B, Park, JH & Bobzin, SC (2006) Detection and quantitation of resveratrol in tomato fruit (Lycopersicon esculentum Mill.). J Agric Food Chem 54, 71757179.
9Cantos, E, Espin, JC & Tomas-Barberan, FA (2002) Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. J Agric Food Chem 50, 56915696.
10Lamuela-Raventós, R, Romero-Pérez, A, Waterhouse, A & de la Torre-Boronat, M (1995) Direct HPLC analysis of cis- and trans-resveratrol and piceic isomers in Spanish red Vitis vinifera wines. J Agric Food Chem 43, 281283.
11Romero Perez, AI, Lamuela Raventos, RM, Waterhouse, AL & de la Torre Boronat, MC (1996) Levels of cis- and trans-resveratrol and their glucosides in white and rosé Vitis vinifera wines from Spain. J Agric Food Chem 44, 21242128.
12Vitrac, X, Bornet, A, Vanderlinde, R, Valls, J, Richard, T, Delaunay, JC, Merillon, JM & Teissedre, PL (2005) Determination of stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, ɛ-viniferin) in Brazilian wines. J Agric Food Chem 53, 56645669.
13Landrault, N, Larronde, F, Delaunay, J, Castagnino, C, Vercauteren, J, Mérillon, J, Gasc, F, Cros, G & Teissedre, P (2002) Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development. J Agric Food Chem 50, 20462052.
14Delmas, D, Lancon, A, Colin, D, Jannin, B & Latruffe, N (2006) Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 7, 423442.
15Signorelli, P & Ghidoni, R (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 16, 449466.
16Dore, S (2005) Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity. Neurosignals 14, 6170.
17Fremont, L (2000) Biological effects of resveratrol. Life Sci 66, 663673.
18Olas, B & Wachowicz, B (2005) Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets 16, 251260.
19Juan, ME, Gonzalez-Pons, E, Munuera, T, Ballester, J, Rodriguez-Gil, JE & Planas, JM (2005) trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr 135, 757760.
20Baur, JA & Sinclair, DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5, 493506.
21Ingram, DK, Zhu, M, Mamczarz, J, Zou, S, Lane, MA, Roth, GS & deCabo, R (2006) Calorie restriction mimetics: an emerging research field. Aging Cell 5, 97108.
22Baur, JA, Pearson, KJ, Price, NL, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337342.
23Delmas, D, Jannin, B & Latruffe, N (2005) Resveratrol: preventing properties against vascular alterations and ageing. Mol Nutr Food Res 49, 377395.
24Orallo, F (2006) Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Curr Med Chem 13, 8798.
25Goldberg, DM, Yan, J & Soleas, GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36, 7987.
26Meng, X, Maliakal, P, Lu, H, Lee, MJ & Yang, CS (2004) Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 52, 935942.
27Soleas, GJ, Yan, J & Goldberg, DM (2001) Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr B Biomed Sci Appl 757, 161172.
28Urpi-Sarda, M, Jauregui, O, Lamuela-Raventos, RM, Jaeger, W, Miksits, M, Covas, M & Andres-Lacueva, C (2005) Uptake of diet resveratrol into the human low density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Anal Chem 77, 31493155.
29Vitaglione, P, Sforza, S, Galaverna, G, Ghidini, C, Caporaso, N, Vescovi, PP, Fogliano, V & Marchelli, R (2005) Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res 49, 495504.
30Walle, T, Hsieh, F, DeLegge, MH, Oatis, JE & Walle, UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 13771382.
31Yu, C, Shin, YG, Chow, A, Li, Y, Kosmeder, JW, Lee, YS, Hirschelman, WH, Pezzuto, JM, Mehta, RG & van Breemen, RB (2002) Human, rat, and mouse metabolism of resveratrol. Pharm Res 19, 19071914.
32Zamora-Ros, R, Urpi-Sarda, M, Lamuela-Raventos, RM, Estruch, R, Vazquez-Agell, M, Serrano-Martinez, M, Jaeger, W & Andres-Lacueva, C (2006) Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin Chem 52, 13731380.
33Koga, T & Meydani, M (2001) Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr 73, 941948.
34Moon, JH, Tsushida, T, Nakahara, K & Terao, J (2001) Identification of quercetin 3-O-β-d-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30, 12741285.
35Boocock, DJ, Patel, KR, Faust, GES, Normolle, DP, Marczylo, TH, Crowell, JA, Brenner, DE, Booth, TD, Gescher, A & Steward, WP (2007) Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 848, 182187.
36Gonzalez, CA, Navarro, C, Martinez, C, et al. (2004) The European Prospective Investigation into Cancer and Nutrition (EPIC) (article in Spanish). Rev Esp Salud Publica 78, 167176.
37Anonymous (1997) Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. EPIC Group of Spain. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26, Suppl. 1, S91S99.
38Anonymous (1997) Relative validity and reproducibility of a diet history questionnaire in Spain. II. Nutrients. EPIC Group of Spain. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26, Suppl. 1, S100S109.
39Moller, A, Rhodes, M, Preece, R, Walker, A, Atkins, D, Bailey, G, van Klaveren, J & Vittozzi, L (1998) Proposal for the structure and organisation of a future European database Report no. 3. EU-AIR NETTOX (1995–1997).http://www.foodcomp.dk/basis/ (accessed 15 December 2006).
40Trela, BC & Waterhouse, AL (1996) Resveratrol: isomeric molar absorptivities and stability. J Agric Food Chem 44, 12531257.
41Ministerio de Agricultura Pesca y Alimentación (2004) La Alimentación en España. 2003 (Food in Spain.2003). Madrid: Ministerio de Agricultura Pesca y Alimentación.
42Instituto Nacional de Estadística (2005) Instituto Nacional de Estadística (National Statistics Institute)http://www.ine.es (accessed 15 December 2006).
43Flanders, WD, DerSimonian, R & Freedman, DS (1992) Interpretation of linear regression models that include transformations or interaction terms. Ann Epidemiol 2, 735744.
44R Development Core Team (2006) A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
45Alarcón de la Lastra, C & Villegas, I (2005) Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 49, 405430.
46Moreno-Labanda, J, Mallavia, R, Pérez-Fons, L, Lizama, V, Saura, D & Micol, V (2004) Determination of piceid and resveratrol in Spanish wines deriving from Monastrell (Vitis vinifera L.) grape variety. J Agric Food Chem 52, 53965403.
47Lee, S, Lee, S, Kim, M, Chun, J, Cheong, Y & Lee, J (2004) Analysis of trans-resveratrol in peanuts and peanut butters consumed in Korea. Food Res Intern 37, 247251.
48Nicoletti, I, De Rossi, A, Giovinazzo, G & Corradini, D (2007) Identification and quantification of stilbenes in fruits of transgenic tomato plants (Lycopersicon esculentum Mill.) by reversed phase HPLC with photodiode array and mass spectrometry detection. J Agric Food Chem 55, 33043311.
49Sieri, S, Agudo, A, Kesse, E, et al. (2002) Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project. Public Health Nutr 5, 12871296.
50Guallar-Castillón, P, Rodríguez-Artalejo, F, Díez-Gañan, L, Banegas Banegas, JR, Lafuente Urdionguio, P & Herruzo Cabrera, R (2001) Consumption of alcoholic beverages and subjective health in Spain. J Epidemiol Community Health 55, 648652.
51Marques-Vidal, P & Dias, CM (2005) Trends and determinants of alcohol consumption in Portugal: results from the national health surveys 1995 to 1996 and 1998 to 1999. Alcohol Clin Exp Res 29, 8997.
52Levi, F, Pasche, C, Lucchini, F, Ghidoni, R, Ferraroni, M & La Vecchia, C (2005) Resveratrol and breast cancer risk. Eur J Cancer Prev 14, 139142.
53Kuhnle, G, Spencer, JPE, Chowrimootoo, G, Schroeter, H, Debnam, ES, Srai, SKS, Rice-Evans, C & Hahn, U (2000) Resveratrol is absorbed in the small intestine as resveratrol glucuronide. Biochem Biophys Res Commun 272, 212217.
54Henry-Vitrac, C, Desmouliere, A, Girand, D, Merillon, JM & Krisa, S (2006) Transport, deglycosilation, and metabolism of trans-piceid by small intestinal epithelial cells. Eur J Nutr 45, 376382.
55Potischman, N (2003) Biologic and methodologic issues for nutritional biomarkers. J Nutr 133, Suppl. 3, 875S880S.
56Kelemen, LE (2006) Food frequency questionnaires: not irrelevant yet. Cancer Epidemiol Biomarkers Prev 15, 1054.
57Szmitko, PE & Verma, S (2005) Cardiology patient pages. Red wine and your heart. Circulation 111, e10e11.
58Aranceta, J, Perez, C, Eguileor, I, Gonzalez de Goldeano, J, Mataix, J & Saez de Burauga, J (1990) Nutritional Survey. Technical Documents of Public Health, ser. A, no. 9. Vitoria, Spain: Government of the Basque Country.
59Mataix, J, Llopis, J, Martinez de Victoria, E, Montellano, MA, Lopez, M & Aranda, P (1999) Evaluation of the Nutritional Status in the Autonomous Community of Andalucia. Granada, Spain: Public Health Service and Institute of Nutrition and Food Technology of the University of Granada.
60Goldberg, DM, Karumanchiri, A, Ng, E, Yan, J, Diamandis, EP & Soleas, GJ (1995) Direct gas-chromatographic mass-spectrometric method to assay cis-resveratrol in wines – preliminary survey of its concentration in commercial wines. J Agric Food Chem 43, 12451250.
61Rodriguez-Delgado, M, González, G, Pérez-Trujillo, J & García-Montelongo, F (2002) Trans-resveratrol in wines from the Canary Islands (Spain). Analysis by high performance liquid chromatography. Food Chem 76, 371375.
62Álvarez-Sala, L, Slowing-Barrillas, K, Gómez-Serranillos, P, Torres-Segovia, F, Valderrama-Rojas, M & Millán-Núñez, J (2000) Variabilidad del contenido de polifenoles de distintos tipos de vino y su potencial aplicación al conocimiento de sus efectos biológicos (Variability of the content of polyphenols of different types from wine and potential application from the knowledge of their biological effects). Med Clin (Barc) 114, 331332.
63Martinez-Ortega, MV, Carcia-Parrilla, MC & Troncoso, AM (2000) Resveratrol content in wines and musts from the south of Spain. Nahrung 44, 253256.
64Andres-Lacueva, C, Ibern-Gomez, M, Lamuela-Raventos, RM, Buxaderas, S & de la Torre-Boronat, M (2002) Cinnamates and resveratrol content for sparkling wine characterization. Am J Enol Vitic 53, 147150.
65Pozo-Bayon, MA, Hernandez, MT, Martin-Alvarez, PJ & Polo, MC (2003) Study of low molecular weight phenolic compounds during the aging of sparkling wines manufactured with red and white grape varieties. J Agric Food Chem 51, 20892095.
66de Lima, M, Waffo-Téguo, P, Teissedre, P, Pujolas, A, Vercauteren, J, Cabanis, J & Mérillon, J (1999) Determination of stilbenes (trans-astringin, cis- and trans-piceid, and cis- and trans-resveratrol) in Portuguese wines. J Agric Food Chem 47, 26662670.
67Goldberg, DM, Yan, J, Ng, E, Diamandis, EP, Karumanchiri, A, Soleas, G & Waterhouse, AL (1995) A global survey of trans-resveratrol concentrations in commercial wines. Am J Enol Vitic 46, 159165.
68Cantos, E, Espin, JC & Tomas-Barberan, FA (2002) Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses. J Agric Food Chem 50, 63226329.
69Cantos, E, Tomas-Barberan, FA, Martinez, A & Espin, JC (2003) Differential stilbene induction susceptibility of seven red wine grape varieties upon post-harvest UV-C irradiation. Eur Food Res Technol 217, 253258.
70Vinas, P, Lopez-Erroz, C, Marin-Hernandez, JJ & Hernandez-Cordoba, M (2000) Determination of phenols in wines by liquid chromatography with photodiode array and fluorescence detection. J Chromatogr A 871, 8593.
71Roldan, A, Palacios, V, Caro, I & Perez, L (2003) Resveratrol content of Palomino fino grapes: influence of vintage and fungal infection. J Agric Food Chem 51, 14641468.
72Romero-Perez, AI, Ibern-Gomez, M, Lamuela-Raventos, RM & Torre-Boronat, MC (1999) Piceid, the major resveratrol derivative in grape juices. J Agric Food Chem 47, 15331536.
73Ibern-Gomez, M, Roig-Pérez, S, Lamuela-Raventos, RM & de la Torre-Boronat, M (2000) Resveratrol and piceid levels in natural and blended peanut butters. J Agric Food Chem 48, 63526354.
74Zhang, K & Zuo, YG (2004) GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem 52, 222227.
75Lyons, MM, Yu, C, Toma, RB, Cho, SY, Reiboldt, W, Lee, J & van Breemen, RB (2003) Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 51, 58675870.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 44
Total number of PDF views: 242 *
Loading metrics...

Abstract views

Total abstract views: 529 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th July 2018. This data will be updated every 24 hours.