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Dietary intake of fish and PUFA, and clinical depressive and anxiety disorders in women

  • Felice N. Jacka (a1) (a2), Julie A. Pasco (a1) (a3) (a4), Lana J. Williams (a1) (a2), Barbara J. Meyer (a5), Rebecca Digger (a5) and Michael Berk (a1) (a2) (a6) (a7)...

Fish and PUFA consumption are thought to play a role in mental health; however, many studies do not take into account multiple sources of PUFA. The present study analysed data from a sample of 935 randomly selected, population-based women aged 20–93 years. A validated and comprehensive dietary questionnaire ascertained the consumption of n-3 and n-6 PUFA. Another assessed fish and energy intake and provided data for a dietary quality score. The General Health Questionnaire-12 (GHQ-12) measured psychological symptoms and a clinical interview (Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition) assessed depressive and anxiety disorders. Median dietary intakes of long-chain n-3 fatty acids (310 mg/d) were below suggested dietary target levels. The only PUFA related to categorical depressive and anxiety disorders was DHA. There was a non-linear relationship between DHA intake and depression; those in the second tertile of DHA intake were nearly 70 % less likely to report a current depressive disorder compared to those in the first tertile. The relationship of DHA to anxiety disorders was linear; for those in the highest tertile of DHA intake, the odds for anxiety disorders were reduced by nearly 50 % after adjustments, including adjustment for diet quality scores, compared to the lowest tertile. Those who ate fish less than once per week had higher GHQ-12 scores, and this relationship was particularly obvious in smokers. These are the first observational data to indicate a role for DHA in anxiety disorders, but suggest that the relationship between DHA and depressive disorders may be non-linear.

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*Corresponding author: Dr F. N. Jacka, fax +61 3 5222 2420, email
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4P Howe , B Meyer , S Record , et al. (2006) Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources. Nutrition 22, 4753.

5M Maes , R Smith , A Christophe , et al. (1996) Fatty acid composition in major depression: decreased omega 3 ratio in cholesteryl esters and phospholipids. J Affective Disord 38, 3546.

6M Maes , A Christophe , J Delanghe , et al. (1999) Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 85, 275291.

7M Peet , B Murphy , J Shay , et al. (1998) Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 43, 315319.

8P Adams , S Lawson , A Sanigorski , et al. (1996) Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 31, 157161.

9JK Kiecolt-Glaser , MA Belury , K Porter , et al. (2007) Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults. Psychosom Med 69, 217224.

10KM Appleton , PJ Rogers & AR Ness (2010) Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood. Am J Clin Nutr 91, 757770.

12A Tanskanen , JR Hibbeln , J Tuomilehto , et al. (2001) Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv 52, 529531.

13LA Colangelo , K He , MA Whooley , et al. (2009) Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women. Nutrition 25, 10111019.

14KM Silvers & KM Scott (2002) Fish consumption and self-reported physical and mental health status. Public Health Nutr 5, 427431.

15V Bountziouka , E Polychronopoulos , A Zeimbekis , et al. (2009) Long-term fish intake is associated with less severe depressive symptoms among elderly men and women: the MEDIS (MEDiterranean ISlands Elderly) epidemiological study. J Aging Health 21, 864880.

16KM Appleton , JV Woodside , JW Yarnell , et al. (2007) Depressed mood and dietary fish intake: direct relationship or indirect relationship as a result of diet and lifestyle? J Affect Disord 104, 217223.

17KM Appleton , TJ Peters , RC Hayward , et al. (2007) Depressed mood and n-3 polyunsaturated fatty acid intake from fish: non-linear or confounded association? Soc Psychiatry Psychiatr Epidemiol 42, 100104.

18R Hakkarainen , T Partonen , J Haukka , et al. (2004) Is low dietary intake of omega-3 fatty acids associated with depression? Am J Psychiatry 161, 567569.

19K Murakami , T Mizoue , S Sasaki , et al. (2008) Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 24, 140147.

20A Sanchez-Villegas , P Henriquez , A Figueiras , et al. (2007) Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. Eur J Nutr 46, 337346.

21AR Wolfe , EM Ogbonna , S Lim , et al. (2009) Dietary linoleic and oleic fatty acids in relation to severe depressed mood: 10 years follow-up of a national cohort. Prog Neuropsychopharmacol Biol Psychiatry 33, 972977.

22FN Jacka , JA Pasco , A Mykletun , et al. (2010) Association between western and traditional diets and depression and anxiety in women. Am J Psychiatry 167, 305311.

25A Hodge , AJ Patterson , WJ Brown , et al. (2000) The Anti Cancer Council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation. Aust N Z J Public Health 24, 576583.

27M Swierk , PG Williams , J Wilcox , et al. (2010) Validation of an Australian electronic food frequency questionnaire to measure polyunsaturated fatty acid intake. Nutrition 27, 641646.

29CE Collins , AF Young & A Hodge (2008) Diet quality is associated with higher nutrient intake and self-rated health in mid-aged women. J Am Coll Nutr 27, 146157.

33BJ Meyer , NJ Mann , JL Lewis , et al. (2003) Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 38, 391398.

34P Green , H Hermesh , A Monselise , et al. (2006) Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder. Eur Neuropsychopharmacol 16, 107113.

35C Song , X Li , BE Leonard , et al. (2003) Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. J Lipid Res 44, 19841991.

36L Buydens-Branchey & M Branchey (2006) n-3 Polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers. J Clin Psychopharmacol 26, 661665.

37T Hamazaki , S Sawazaki , M Itomura , et al. (1996) The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest 97, 11291133.

38D Mischoulon , C Best-Popescu , M Laposata , et al. (2008) A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder. Eur Neuropsychopharmacol 18, 639645.

39K Murakami & S Sasaki (2010) Dietary intake and depressive symptoms: a systematic review of observational studies. Mol Nutr Food Res 54, 471488.

40FN Jacka , PJ Kremer , M Berk , et al. (2011) A prospective study of diet quality and mental health in adolescents. PLoS One 6, e24805.

41FN Jacka , A Mykletun , M Berk , et al. (2011) The association between habitual diet quality and the common mental disorders in community-dwelling adults: the Hordaland Health study. Psychosom Med 73, 483490.

42FN Jacka , JA Pasco , A Mykletun , et al. (2011) Diet quality in bipolar disorder in a population-based sample of women. J Affective Disorders 129, 332337.

43J Sontrop , WR Avison , SE Evers , et al. (2008) Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids. Paediatr Perinat Epidemiol 22, 389399.

44L Ashakumary & PL Vijayammal (1996) Additive effect of alcohol and nicotine on lipid peroxidation and antioxidant defence mechanism in rats. J Appl Toxicol 16, 305308.

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British Journal of Nutrition
  • ISSN: 0007-1145
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