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Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects

  • Manuela P. G. M. Lejeune (a1), Eva M. R. Kovacs (a1) and Margriet S. Westerterp-Plantenga (a1)

The aim of the present study was to investigate whether capsaicin assists weight maintenance by limiting weight regain after weight loss of 5 to 10%. In this randomized double-blind placebo-controlled study, ninety-one moderately overweight subjects were randomly assigned to an intensive group that underwent all the measurements, and an extensive group that underwent the same measurements except the metabolism measurements. After a 4-week very-low-energy diet (VLED) intervention, a 3-month weight-maintenance period followed. During weight maintenance, subjects were divided into a capsaicin (135 mg capsaicin/d) and a placebo group. Body mass was measured before and after the VLED and after 1, 2 and 3 months of weight maintenance. The mean body-mass loss during the VLED was 6·6 (sd 2·0) kg (7·8 (sd 1·8)% initial body mass), and was not different between the subsequent treatment and placebo group. During weight maintenance, mean % regain during treatment was not significantly different compared with placebo (33·3 (sd 35·7) v. 19·2 (sd 41·8)%, P=0·09). RQ was significantly less increased during weight maintenance in the treatment group compared with placebo (0·04 (sd 0·06) v. 0·07 (sd 0·05), P < 0·05), indicating a relatively more sustained fat oxidation. Fat oxidation (g/h) after weight maintenance was higher in the capsaicin group compared with placebo (4·2 (sd 1·1) v. 3·5 (sd 0·9), P < 0·05). These results indicate that capsaicin treatment caused sustained fat oxidation during weight maintenance compared with placebo. However, capsaicin treatment has no limiting effect on 3-month weight regain after modest weight loss.

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Corresponding author
*Corresponding author: Ms Manuela P. G. M. Lejeune, fax +31 43 3670976, email M.Lejeune@HB.UNIMAAS.NL
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Clark MM, Marcus BH, Pera V & Niaura R (1994) Changes in eating inventory scores following obesity treatment. Int J Eat Disord 15, 401405.
Ekelund U, Yngve A, Sjöström M & Westerterp KR (2000) Field evaluation of the computer science and application's inc. activity monitor during running and skating training in adolescent athletes. Int J Sports Med 21, 586592.
Goldstein DJ (1992) Beneficial effects of modest weight loss. Int J Obes 16, 397415.
Goris AH & Westerterp KR (1999) Underreporting of habitual food intake is explained by undereating in highly motivated lean women. J Nutr 129, 878882.
Goris AH & Westerterp KR (2000) Improved reporting of habitual food intake after confrontation with earlier results on food reporting. Br J Nutr 83, 363369.
Goris AH, Westerterp-Plantenga MS & Westerterp KR (2000) Undereating and underrecording of habitual food intake in obese men: selective underreporting of fat intake. Am J Clin Nutr 71, 130134.
Goris AHC, Meijer EP, Kester A & Westerterp KR (2001) Use of a triaxial accelerometer to validate reported food intakes. Am J Clin Nutr 73, 549553.
Herman CP & Polivy J (1980) Restrained eating. In Obesity, pp. 208224 [Stunkard AJ, editor]. Philadelphia, PA: W. B. Saunders.
Hubert HB, Feinleib M, McNamara PM & Castelli WP (1983) Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67, 968977.
Kawada T, Hagihara K & Iwai K (1986) Effects of capsaicin on lipid metabolism in rats fed high fat diet. J Nutr 116, 12721278.
Kawada T, Sakabe S, Watanabe T, Yamamoto M & Iwai K (1988) Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthesized rats. Proc Soc Exp Biol Med 188, 229233.
Kramer FM, Jeffery RW, Forster JL & Snell MK (1989) Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes 13, 123136.
Kromhout D (1983) Body weight, diet, and serum cholesterol in 871 middle-aged men during 10 years of follow-up (the Zutphen Study). Am J Clin Nutr 38, 591598.
Noppa H (1980) Body weight change in relation to incidence of ischemic heart disease and change in risk factors for ischemic heart disease. Am J Epidemiol 111, 693704.
Pasman WJ, Saris WH & Westerterp-Plantenga MS (1998) Predictors of weight maintenance. Obes Res 7, 4350.
Pasman WJ, Saris WHM, Muls E, Vansant G & Westerterp-Plantenga MS (1999) The effect of exercise training on long-term weight maintenance in weight-reduced men. Metabolism 48, 1521.
Pasman WJ, Westerterp-Plantenga MS, Muls E, Vansant G, Van Ree J & Saris WHM (1997 a) The effectiveness of long-term fiber supplementation on weight maintenance in weight reduced women. Int J Obes 21, 548555.
Pasman WJ, Westerterp-Plantenga MS & Saris WHM (1997 b) The effectiveness of long-term supplementation of carbohydrate, chromium, fiber and caffeine on weight maintenance. Int J Obes 21, 11431151.
Pekkarinen T, Takala I & Mustajoki P (1996) Two year maintenance of weight loss after a VLCD and behavioural therapy for obesity: correlation to the scores of questionnaires measuring eating behaviour. Int J Obes 20, 332337.
Péronnet F & Massicotte D (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16, 2329.
Pullar JD & Webster AJF (1977) The energy cost of fat and protein deposition in the rat. Br J Nutr 37, 355363.
Ravussin E & Bogardus C (1989) Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr 49, 968975.
Ravussin E, Fontvieille AM, Swinburn BA & Bogardus C (1993) Risk factors for the development of obesity. Ann N Y Acad Sci 683, 141150.
Schoeller DA, Van Santen E, Peterson DW, Diez W, Jaspan J & Klein PD (1980) Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr 33, 26862693.
Schoffelen PFM, Westerterp KR, Saris WHM & Ten Hoor F (1997) A dual respiration chamber with automated calibration. J Appl Physiol 83, 20642072.
Schutz Y (1995) Abnormalities of fuel utilization as predisposing to the development of obesity in humans. Obes Res 3, 173S178S.
Seidell JC (1995) Obesity in Europe. Obes Res 3, Suppl. 2, 249s259s.
Seidell JC, Muller DC, Sorkin JD & Andres R (1992) Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes 16, 667674.
Stunkard AJ & Messick S (1985) The three factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychol Res 29, 7183.
Van Gaal LF, Wauters MA & De Leeuw IH (1997) The beneficial effects of modest weight loss on cardiovascular risk factors. Int J Obes 21, Suppl. 1, S5S9.
Van Marken Lichtenbelt WD, Westerterp KR & Wouters L (1994) Deuterium dilution as a method for determining total body water: effect of test protocol and sampling time. Br J Nutr 72, 491497.
Wadden TA, Stunkard AJ & Liebschutz J (1988) Three-year follow-up of the treatment of obesity by very low calorie diet, behavior therapy, and their combination. J Consult Clin Psychol 56, 925928.
Weir JBDV (1949) New methods for calculating metabolic rate with special references to protein metabolism. J Physiol 109, 19.
Westerterp-Plantenga MS, Kempen KPG & Saris WHM (1998) Determinants of weight maintenance in women after diet-induced weight reduction. Int J Obes 22, 16.
Westerterp-Plantenga MS, Rolland V, Wilson SAJ & Westerterp KR (1999) Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs. high fat diets measured in a respiration chamber. Eur J Clin Nutr 53, 495502.
Wing RR, Jeffery RW, Burton LR, Thorson C, Kuller LH & Folsom AR (1992) Change in waist-hip ratio with weight loss and its association with change in cardiovascular risk factors. Am J Clin Nutr 55, 10861092.
Yoshioka M, Doucet E, Drapeau V, Dionne I & Tremblay A (2001) Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85, 203211.
Yoshioka M, Lim K, Kikuzato S, et al. (1995) Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 41, 647656.
Yoshioka M, St-Pierre S, Drapeau V, et al. (1999) Effects of red pepper on appetite and energy intake. Br J Nutr 82, 115123.
Yoshioka M, St-Pierre S, Suzuki M & Tremblay A (1998) Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 80, 503510.
Zurlo F, Lillioja S, Esposito-Del Puente A, et al. (1990) Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259, E650E657.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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