Skip to main content
×
Home
    • Aa
    • Aa

Effect of food composition on vitamin K absorption in human volunteers

  • Birgit L. M. G. Gijsbers (a1), Kon-Siong G. Jie (a1) and Cees Vermeer (a1)
Abstract

The human vitamin K requirement is not known precisely, but the minimal requirement is often assumed to be between 0·5 and 1 x 10−6g/kg body weight. In the present study we addressed the question to what extent circulating vitamin K concentrations are influenced by the form in which the vitamer is consumed. The experimental group consisted of five healthy volunteers who received phylloquinone after an overnight fast. On the first day of three successive weeks the participants consumed 1 mg (2·2 µmol) phylloquinone, either in the form of a pharmaceutical preparation (Konakion®), or in the form of spinach + butter, or as spinach without added fat. Circulating phylloquinone levels after spinach with and without butter were substantially lower (7·5- and 24·3-fold respectively) than those after taking the pharmaceutical concentrate. Moreover, the absorption of phylloquinone from the vegetables was 1·5 times slower than from Konakion. In a second experiment in the same five volunteers it was shown that relatively high amounts of menaquinone-4 enter the circulation after the consumption of butter enriched with this vitamer. It is concluded that the bioavailability of membrane-bound phylloquinone is extremely poor and may depend on other food components, notably fat. The bioavailability of dietary vitamin K (phylloquinone+menaquinones) is lower than generally assumed, and depends on the form in which the vitamin is ingested. These new insights may lead to a revision of the recommended daily intake for vitamin K.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of food composition on vitamin K absorption in human volunteers
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effect of food composition on vitamin K absorption in human volunteers
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effect of food composition on vitamin K absorption in human volunteers
      Available formats
      ×
Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

S.L. Booth , J.A. Sadowski , J.L. Weihrauch & G. Ferland (1993). Vitamin K1 (phylloquinone) content of foods: a provisional table. Journal of Food Composition and Analysis 6, 109120.

M. M. C. L. Groenen-van Dooren , J. E. Ronden , B. A. M. Soute & C. Vermeer (1995). Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in the vitamin K-deficient rat. Biochemical Pharmacology 50, 797801.

M. M. C. L. Groenen-van Dooren , B. A. M. Soute , K.-S. G. Jie , H. H. W. Thijssen & C. Vermeer (1993). The relative effects of phylloquinone and menaquinone on the blood coagulation factor synthesis in vitamin K-deficient rats. Biochemical Pharmacology 46, 433437.

J. P. Hart , M. J. Shearer , L. Klenerman , A. Caterall , J. Reeve , P.N. Sambrook , R.A Dodds , L.& Bitensky J. Chayen (1985). Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Journal of Clinical Endocrinology and Metabolism 60, 12681269.

J. J. Lipsky (1988). Antibiotic-associated hypoprothrombinaemia. Journal of Antimicrobial Chemotherapy 21, 281300.

J. J. Lipsky (1994). Nutritional sources of vitamin K. Mayo Clinic Proceedings 69, 462466.

G. Manfioletti , C. Brancolini , G. Avanzi & C. Schneider (1993). The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Molecular and Cellular Biology 13, 49764985.

M. J. Shearer , A. McBurney & P. Barkhan (1974). Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man. Vitamins and Hormones 32, 513542.

J. W. Suttie (1985). Vitamin K-dependent carboxylase. Annual Review of Biochemistry 54, 459477.

H. H. W. Thijssen & M. J. Drittij-Reijnders (1993). Vitamin K metabolism and vitamin K1 status in human liver samples: a search for inter-individual differences in warfarin sensitivity. British Journal of Haematology 84, 681685.

C. Vermeer (1990). Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochemical Journal 266, 625636.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score