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Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults

  • Paul J. Nestel (a1), Natalie Mellett (a1), Suzana Pally (a1), Gerard Wong (a1), Chris K. Barlow (a1), Kevin Croft (a2), Trevor A. Mori (a2) and Peter J. Meikle (a1)...
Abstract

The association between consumption of full-fat dairy foods and CVD may depend partly on the nature of products and may not apply to low-fat dairy foods. Increased circulating levels of inflammatory biomarkers after consumption of dairy product-rich meals suggest an association with CVD. In the present study, we tested the effects of low-fat and full-fat dairy diets on biomarkers associated with inflammation, oxidative stress or atherogenesis and on plasma lipid classes. Within full-fat dairy diets, we also compared fermented v. non-fermented products. In a randomised cross-over study, twelve overweight/obese subjects consumed during two 3-week periods two full-fat dairy diets containing either yogurt plus cheese (fermented) or butter, cream and ice cream (non-fermented) or a low-fat milk plus yogurt diet, with the latter being consumed between and at the end of the full-fat dairy dietary periods. The concentrations of six inflammatory and two atherogenic biomarkers known to be raised in CVD were measured as well as those of plasma F2-isoprostanes and lipid classes. The concentrations of six of the eight biomarkers tended to be higher on consumption of the low-fat dairy diet than on that of the fermented dairy diet and the concentrations of two plasmalogen lipid classes reported to be associated with increased oxidisability were also higher on consumption of the low-fat dairy diet than on that of the fermented dairy diet (P< 0·001), although plasma F2-isoprostane concentrations did not differ on consumption of any of the diets. On the other hand, the concentrations of plasma sphingomyelin and IL-6 were significantly higher on consumption of the non-fermented dairy diet than on that of the low-fat dairy diet (P< 0·02). In conclusion, short-term diets containing low-fat dairy products did not lead to a more favourable biomarker profile associated with CVD risk compared with the full-fat dairy products, suggesting that full-fat fermented dairy products may be the more favourable.

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Corresponding author
*Corresponding author: Professor P. J. Nestel, email paul.nestel@bakeridi.edu.au
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1P Libby , PM Ridker & A Maseri (2002) Inflammation and atherosclerosis. Circulation 105, 14111415.

2T Pischon , FB Hu , KM Rexrode , et al. (2008) Inflammation, the metabolic syndrome, and risk of coronary heart disease in women and men. Atherosclerosis 197, 392399.

3P Manning , WHF Sutherland , MM McGrath , et al. (2008) Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity 16, 20462052.

4D El-Khoury , N Hwaila , V Frochet , et al. (2010) Postprandial metabolic and hormonal responses of obese dyslipidemic subjects with metabolic syndrome to test meals, rich in carbohydrate, fat or protein. Atherosclerosis 210, 307313.

5D Giugliano , A Ceriello , K Esposito , et al. (2006) The effects of diet on inflammation. J Am Coll Cardiol 48, 677685.

6PJ Nestel , S Pally , GL MacIntosh , et al. (2012) Circulating inflammatory and atherogenic biomarkers are not increased following single meals of dairy foods. Eur J Clin Nutr 66, 2531.

7AM Bernstein , Q Sun , FB Hu , et al. (2010) Major dietary protein sources and risk of coronary heart disease in women. Circulation 122, 859860.

8SS Soedehma-Mutha , EL Ding , WK Al-Delaimy , et al. (2011) Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies. Am J Clin Nutr 93, 158163.

9RA Goldbohm , AMJ Chorus & D Garre (2011) Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr 93, 615627.

10PJ Nestel (2012) Editorial: the changing face of the dairy-cardiovascular risk paradox. Curr Opin Lipidol 23, 13.

11E Warensjo , J-H Jansson , T Cederhol , et al. (2010) Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective matched case–control study. Am J Clin Nutr 92, 194201.

13PC Elwood , JE Pickering , DI Givens , et al. (2010) The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids 45, 925939.

14S Liu , HK Choi & E Ford (2006) A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 29, 15781584.

15PJ Meikle , G Wong , D Tsorotes , et al. (2011) Plasma lipidomic analysis of stable and unstable coronary artery disease. Arterioscler Thromb Vasc Biol 31, 27232732.

16TA Mori , KD Croft , JB Puddey , et al. (1999) An improved method for the measurement of urinary and plasma F2-isoprostanes using gas chromatography mass spectrometry. Anal Biochem 268, 117125.

17The Emerging Risk Factor Collaboration (2010) C-reactive protein and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 375, 132140.

18Heart Protection Study Collaborative Group (2011) C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study. Lancet 377, 469476.

19M Cesari , WJH Pennix , AB Newman , et al. (2003) Inflammatory markers and onset of cardiovascular events. Circulation 108, 23172322.

20I Tzoulaki , GD Murray , AJ Lee , et al. (2005) C-reactive protein, interleukin-6 and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study. Circulation 112, 976983.

21J-P Empana , F Canoui-Poitrine , G Luc , et al. (2008) Contribution of novel biomarkers to incident acute coronary syndrome: the PRIME Study. Eur Heart J 29, 19661974.

22RC Hoogveen , A Morrison , E Boerwinkle , et al. (2005) Plasma MCP-1 level and risk for peripheral atherosclerosis and incident coronary heart disease: Atherosclerosis Risk in Communities Study. Atherosclerosis 183, 301307.

24KR Kelly , JM Haus , TPJ Solomon , et al. (2011) A low-glycemic index diet and exercise intervention reduces TNFα in isolated mononuclear cells in older, obese adults. J Nutr 141, 10891094.

26XC Jiang , F Paultre , TA Pearson , et al. (2000) Plasma sphingomyelin level as a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol 20, 26142618.

27JC Nelson , XC Jiang , I Tabas , et al. (2006) Plasma sphingomyelin and subclinical atherosclerosis findings from the multi-ethnic study of atherosclerosis. Am J Epidemiol 163, 903912.

28C Stegemann , I Drozdov , J Shalhoub , et al. (2011) Comparative lipidomics profiling of human atherosclerotic plaques. Circ Cardiovasc Genet 4, 232242.

29DJ Bolin & A Jonas (1996) Sphingomyelin inhibits the lecithin cholesterol acyl transferase reaction with reconstituted high density lipoproteins by decreasing enzyme binding. J Biol Chem 271, 19151918.

30O Skaff , DI Pattison & MJ Davies (2008) The vinyl ether linkages of plasmalogens are favoured targets for the myeloperoxidase-derived oxidants: a kinetic study. Biochemistry 47, 82378245.

31C Meisinger , J Baumert , N Khuseyinova , et al. (2005) Plasma oxidised low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation 112, 651657.

32RA Stancliffe , T Thorpe & MB Zemel (2011) Dairy attenuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr 94, 422430.

33N Panagiotacos , CH Pitsavos , AD Zampelas , et al. (2010) Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults. J Am Coll Nutr 29, 357364.

34MH Wennersberg , A Smedman , AM Turpeinen , et al. (2009) Dairy products and metabolic effects in overweight men and women: results from 6-mo intervention study. Am J Clin Nutr 90, 960968.

35I Sluijs , NG Forouhi , JWJ Beulens , et al. (2012) The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. Am J Clin Nutr 96, 382390.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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