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Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report

  • Peter Sanderson (a1), Ian T. Johnson (a2), John C. Mathers (a3), Hilary J. Powers (a4), C. Stephen Downes (a5), Angela P. McGlynn (a5), Rae Dare (a5), Ellen Kampman (a6), Beatrice L. Pool-Zobel (a7), Sheila A. Bingham (a8) and Joseph J. Rafter (a9)...
Abstract

The UK Food Standards Agency convened a group of expert scientists to review current research investigating emerging diet-related surrogate end points for colorectal cancer (CRC). The workshop aimed to overview current research and establish priorities for future research. The workshop considered that the validation of current putative diet-related surrogate end points for CRC and the development of novel ones, particularly in the emerging fields of proteomics, genomics and epigenomics, should be a high priority for future research.

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Corresponding author
*Corresponding author: Dr Peter Sanderson, fax +44 20 7276 8906, email peter.sanderson@foodstandards.gsi.gov.uk
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SB Baylin , JG Herman , JR Graff , PM Vertino & JP Issa (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72, 141196.

H Bernstein , H Holubec , JA Warneke (2002) Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Ann Surg Oncol 9, 505517.

SA Bingham , B Pignatelli , JR Pollock (1996) Does increased endogenous formation of N -nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis 17, 515523.

B Diergaarde , WL Van Geloof , GN Van Muijen , FJ Kok & E Kampman (2003) Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study. Carcinogenesis 24, 283290.

MN Ebert , G Beyer-Sehlmeyer , UM Liegibel , T Kautenburger , TW Becker & BL Pool-Zobel (2001) Butyrate-induced activation of glutathione S-transferases protects human colon cells from genetic damage by 4-hydroxynonenal. Nutr Canc 41, 156164.

JD Hayes & RC Strange (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 22, 193207.

JG Herman , A Umar , K Polyak (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci 95, 68706875.

J Hirst & DB Goodin (2000) Unusual oxidative chemistry of N-hydroxyarginine and H-hydroxyguanidine catalysed at an engineered cavity in heme peroxidase. J Biol Chem 275, 85828591.

R Hughes , AJ Cross , JR Pollock & S Bingham (2001) Dose-dependent effect of dietary meat on endogenous colonic N -nitrosation. Carcinogenesis 22, 199202.

PA Jones & D Takai (2001) The role of DNA methylation in mammalian epigenetics. Science 293, 10681070.

KW Kinzler & B Vogelstein (1996) Lessons from hereditary colorectal cancer. Cell 87, 159170.

A Leslie , FA Carey , NR Pratt & RJ Steele (2002) The colorectal adenoma–carcinoma sequence. Br J Surg 89, 845860.

C Martin , A Connelly , TO Keku (2002) Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas. Gastroenterology 123, 17701777.

A Schäferhenrich , W Sendt & J Scheele (2003 b) Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. Food Chem Toxicol 41, 655664.

A Seow , JM Yuan , CL Sun , D Van Den Berg , HP Lee & MC Yu (2002) Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23, 20552061.

B Vogelstein , ER Fearon & SR Hamilton (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319, 525532.

B Vogelstein , D Lane & AJ Levine (2000) Surfing the p53 network. Nature 408, 307310.

PS Yan , T Efferth & HL Chen (2002) Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation. Methods 27, 162169.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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