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Human gut microbiota does not ferment erythritol

  • Eva Arrigoni (a1), Fred Brouns (a2) (a3) and Renato Amadò (a1)
Abstract

Erythritol, a naturally occurring polyol, is gaining attention as a bulk sweetener for human nutrition. Industrially, it is produced from glucose by fermentation. From various studies it is known to be non-cariogenic. Moreover, it is rapidly absorbed in the small intestine and quantitatively excreted in the urine. Only about 10 % enters the colon. Earlier in vitro experiments showed that erythritol remained unfermented for a fermentation period of 12 h. In order to investigate whether fresh human intestinal microbiota is able to adapt its enzyme activities to erythritol, a 24 h lasting fermentation was carried out under well-standardised in vitro conditions. For comparison maltitol, lactulose and blank (faecal inoculum only) were incubated as well. Fermentation patterns were established by following total gas production, hydrogen accumulation, changes in pH value, SCFA production and substrate degradation. Taking all fermentation parameters into account, erythritol turned out to be completely resistant to bacterial attack within 24 h, thus excluding an adaptation within that period. Since under in vivo conditions more easily fermentable substrates enter the colon continuously, it seems very unlikely that erythritol will be fermented in vivo.

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Copyright
Corresponding author
*Corresponding author: Eva Arrigoni, fax +41 44 6321123, email eva.arrigoni@ilw.agrl.ethz.ch
Linked references
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

WO Bernt , JF Borzelleca , G Flamm & IC Munro (1996) Erythritol: a review of biological and toxicological studies. Regul Toxicol Pharmacol 24, S191S197.

FRJ Bornet , A Blayo , F Dauchy & G Slama (1996) Plasma and urine kinetics of erythritol after oral ingestion by healthy humans. Regul Toxicol Pharmacol 24, S280S285.

M Ishikawa , M Miyashita , Y Kawashima , T Nakamura , N Saitou & J Modderman (1996) Effects of oral administration of erythritol on patients with diabetes. Regul Toxicol Pharmacol 24, S303S308.

J Kawanabe , M Hirasawa , T Takeuchi , T Oda & T Ikeda (1992) Non-cariogenicity of erythritol as a substrate. Caries Res 26, 258362.

V Lebet , E Arrigoni & R Amadò (1998) Measurement of fermentation products and substrate disappearance during incubation of dietary fibre sources with human faecal flora. Lebensmitt Wiss Technol 31, 473479.

T Oku & M Okazaki (1996) Laxative threshold of sugar alcohol erythritol in human subjects. Nutr Res 16, 577589.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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