Skip to main content
×
Home
    • Aa
    • Aa

Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial

  • Jo-Anne Gilbert (a1), Denis R. Joanisse (a1), Jean-Philippe Chaput (a2), Pierre Miegueu (a3), Katherine Cianflone (a3), Natalie Alméras (a3) and Angelo Tremblay (a1) (a2)...
Abstract

Dairy products provide Ca and protein which may facilitate appetite control. Conversely, weight loss is known to increase the motivation to eat. This randomised controlled trial verified the influence of milk supplementation on appetite markers during weight loss. Low Ca consumer women participated in a 6-month energy-restricted programme ( − 2508 kJ/d or − 600 kcal/d) and received either a milk supplementation (1000 mg Ca/d) or an isoenergetic placebo (n 13 and 12, respectively). Fasting appetite sensations were assessed by visual analogue scales. Anthropometric parameters and fasting plasma concentrations of glucose, insulin, leptin, ghrelin and cortisol were measured as well. Both groups showed a significant weight loss (P < 0·0001). In the milk-supplemented group, a time × treatment interaction effect showed that weight loss with milk supplementation induced a smaller increase in desire to eat and hunger (P < 0·05). Unlike the placebo group, the milk-supplemented group showed a lower than predicted decrease in fullness ( − 17·1 v. − 8·8; − 12·7 v. 3·3 mm, P < 0·05, measured v. predicted values, respectively). Even after adjustment for fat mass loss, changes in ghrelin concentration predicted those in desire to eat (r 0·56, P < 0·01), hunger (r 0·45, P < 0·05) and fullness (r − 0·40, P < 0·05). However, the study did not show a between-group difference in the change in ghrelin concentration in response to the intervention. These results show that milk supplementation attenuates the orexigenic effect of body weight loss. Trial registration code: ClinicalTrials.gov NTC00729170.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: A. Tremblay, email angelo.tremblay@kin.msp.ulaval.ca
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2A Bauman , M Allman-Farinelli , R Huxley , (2008) Leisure-time physical activity alone may not be a sufficient public health approach to prevent obesity – a focus on China. Obes Rev 9, Suppl. 1, 119126.

3LA Moreno , MC Ochoa , J Warnberg , (2008) Treatment of obesity in children and adolescents. How nutrition can work? Int J Pediatr Obes Suppl 3, Suppl. 1, 7277.

4M Fogelholm (2010) Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev 11, 202221.

5E Doucet , S St-Pierre , N Alméras , (2003) Relation between appetite ratings before and after a standard meal and estimates of daily energy intake in obese and reduced obese individuals. Appetite 40, 137143.

6V Drapeau , N King , M Hetherington , (2007) Appetite sensations and satiety quotient: predictors of energy intake and weight loss. Appetite 48, 159166.

7WJ Pasman , WH Saris & MS Westerterp-Plantenga (1999) Predictors of weight maintenance. Obes Res 7, 4350.

8DA McCarron , CD Morris , HJ Henry , (1984) Blood pressure and nutrient intake in the United States. Science 224, 13921398.

9JP Chaput , C Leblanc , L Perusse , (2009) Risk factors for adult overweight and obesity in the Quebec Family Study: have we been barking up the wrong tree? Obesity 17, 19641970.

12RP Heaney , KM Davies & MJ Barger-Lux (2002) Calcium and weight: clinical studies. J Am Coll Nutr 21, 152S155S.

13GC Major , JP Chaput , M Ledoux , (2008) Recent developments in calcium-related obesity research. Obes Rev 9, 428445.

15S Paradis & M Cabanac (2005) Calcium deficiency cannot induce obesity in rats. Physiol Behav 85, 259264.

16SA McCaughey , CA Forestell & MG Tordoff (2005) Calcium deprivation increases the palatability of calcium solutions in rats. Physiol Behav 84, 335342.

17GC Major , FP Alarie , J Dore , (2009) Calcium plus vitamin D supplementation and fat mass loss in female very low-calcium consumers: potential link with a calcium-specific appetite control. Br J Nutr 101, 659663.

20A Tremblay , J Sevigny , C Leblanc , (1983) The reproducibility of a 3-day dietary record. Nutr Res 3, 819830.

22MD White , G Bouchard , B Buemann , (1997) Energy and macronutrient balances for humans in a whole body metabolic chamber without control of preceding diet and activity level. Int J Obes Relat Metab Disord 21, 135140.

23JB Weir (1949) New method for calculating metabolic rate with special references to protein metabolism. J Physiol 109, 19.

27JA Gilbert , V Drapeau , A Astrup , (2009) Relationship between diet-induced changes in body fat and appetite sensations in women. Appetite 52, 809812.

28E Doucet , P Imbeault , S St-Pierre , (2000) Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord 24, 906914.

29A Harper , A James , A Flint , (2007) Increased satiety after intake of a chocolate milk drink compared with a carbonated beverage, but no difference in subsequent ad libitum lunch intake. Br J Nutr 97, 579583.

30ER Dove , JM Hodgson , IB Puddey , (2009) Skim milk compared with a fruit drink acutely reduces appetite and energy intake in overweight men and women. Am J Clin Nutr 90, 7075.

32MH Wennersberg , A Smedman , AM Turpeinen , (2009) Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study. Am J Clin Nutr 90, 960968.

33E Doucet & J Cameron (2007) Appetite control after weight loss: what is the role of bloodborne peptides? Appl Physiol Nutr Metab 32, 523532.

34JH Hollis & RD Mattes (2007) Effect of increased dairy consumption on appetitive ratings and food intake. Obesity 15, 15201526.

36M Veldhorst , A Smeets , S Soenen , (2008) Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav 94, 300307.

38LC Duckworth , PJ Gately , D Radley , (2009) RCT of a high-protein diet on hunger motivation and weight-loss in obese children: an extension and replication. Obesity 17, 18081810.

39BL Luhovyy , T Akhavan & GH Anderson (2007) Whey proteins in the regulation of food intake and satiety. J Am Coll Nutr 26, 704S7712.

40J Bowen , M Noakes , C Trenerry , (2006) Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J Clin Endocrinol Metabo 91, 14771483.

41MMJW Kamphuis , MPGM Lejeune , WHM Saris , (2003) Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Eur J Clin Nutr 57, 12681274.

42AA AbuGhazaleh , DO Felton & SA Ibrahim (2007) Milk conjugated linoleic acid response to fish oil and sunflower oil supplementation to dairy cows managed under two feeding systems. J Dairy Sci 90, 47634769.

43V Drapeau , J Blundell , F Therrien , (2005) Appetite sensations as a marker of overall intake. Br J Nutr 93, 273280.

44D Teegarden & CW Gunther (2008) Can the controversial relationship between dietary calcium and body weight be mechanistically explained by alterations in appetite and food intake? Nutr Rev 66, 601605.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: