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Oral sensitivity to fatty acids, food consumption and BMI in human subjects

  • Jessica E. Stewart (a1), Christine Feinle-Bisset (a2) (a3), Matthew Golding (a4), Conor Delahunty (a5), Peter M. Clifton (a3) (a6) and Russell S. J. Keast (a1)...
Abstract

Fatty acids are the chemical moieties that are thought to stimulate oral nutrient sensors, which detect the fat content of foods. In animals, oral hypersensitivity to fatty acids is associated with decreased fat intake and body weight. The aims of the present study were to investigate oral fatty acid sensitivity, food selection and BMI in human subjects. The study included two parts; study 1 established in thirty-one subjects (29 (sem 1·4) years, 22·8 (sem 0·5) kg/m2) taste thresholds using 3-AFC (3-Alternate Forced Choice Methodology) for oleic, linoleic and lauric acids, and quantified oral lipase activity. During study 2, fifty-four subjects (20 (sem 0·3) years, 21·5 (sem 0·4) kg/m2) were screened for oral fatty acid sensitivity using oleic acid (1·4 mm), and they were defined as hypo- or hypersensitive via triplicate triangle tests. Habitual energy and macronutrient intakes were quantified from 2 d diet records, and BMI was calculated from height and weight. Subjects also completed a fat ranking task using custard containing varying amounts (0, 2, 6 and 10 %) of fat. Study 1 reported median lipase activity as 2 μmol fatty acids/min per l, and detection thresholds for oleic, linoleic and lauric acids were 2·2 (sem 0·1), 1·5 (sem 0·1) and 2·6 (sem 0·3) mm. Study 2 identified twelve hypersensitive subjects, and hypersensitivity was associated with lower energy and fat intakes, lower BMI (P < 0·05) and an increased ability to rank custards based on fat content (P < 0·05). Sensitivity to oleic acid was correlated to performance in the fat ranking task (r 0·4, P < 0·05). These data suggest that oral fatty acid hypersensitivity is associated with lower energy and fat intakes and BMI, and it may serve as a factor that influences fat consumption in human subjects.

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Corresponding author
*Corresponding author: Dr Russell Keast, fax +61 3 9244 6017, email russell.keast@deakin.edu.au
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1GA Bray , S Paeratakul & BM Popkin (2004) Dietary fat and obesity: a review of animal, clinical and epidemiological studies. Physiol Behav 83, 549555.

2TA Gilbertson , L Liu , DA York , (1998) Dietary fat preferences are inversely correlated with peripheral gustatory fatty acid sensitivity. Ann N Y Acad Sci 855, 165168.

3A Chale-Rush , JR Burgess & RD Mattes (2007) Evidence for human orosensory (taste?) sensitivity to free fatty acids. Chem Senses 32, 423431.

5RD Mattes (2009) Oral detection of short-, medium-, and long-chain free fatty acids in humans. Chem Senses 34, 145150.

7D Gaillard , F Laugerette , N Darcel , (2008) The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J 22, 14581468.

9J Chandrashekar , MA Hoon , NJ Ryba , (2006) The receptors and cells for mammalian taste. Nature 444, 288294.

10ME Dinehart , JE Hayes , LM Bartoshuk , (2006) Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav 87, 304313.

12C Kobayashi , LM Kennedy & BP Halpern (2006) Experience-induced changes in taste identification of monosodium glutamate (MSG) are reversible. Chem Senses 31, 301306.

13PM Wise , JL Hansen , DR Reed , (2007) Twin study of the heritability of recognition thresholds for sour and salty taste. Chem Senses 32, 749754.

14FL Zhao & S Herness (2009) Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells. J Physiol 587, 363377.

16TJ Little , KL Feltrin , M Horowitz , (2005) Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 289, R1090R1098.

20DA Forss (1972) Odor and flavor compounds from lipids. Prog Chem Fats Other Lipids 13, 177258.

23CV Harris , AS Bradlyn , J Coffman , (2008) BMI-based body size guides for women and men: development and validation of a novel pictorial method to assess weight-related concepts. Int J Obes (Lond) 32, 336342.

24BN Tepper & RJ Nurse (1998) PROP taster status is related to fat perception and preference. Ann N Y Acad Sci 855, 802804.

25JA Nasser , HR Kissileff , CN Boozer , (2001) PROP taster status and oral fatty acid perception. Eat Behav 2, 237245.

26LM Smith , AJ Cliford , CL Hamblin , (1986) Changes in physical and chemical properties of shortenings used for commercial deep fat frying. J Am Oil Chem Soc 63, 10171023.

28M Bertino , GK Beauchamp & K Engelman (1986) Increasing dietary salt alters salt taste preference. Physiol Behav 38, 203213.

30JH Ledikwe , J Ello-Martin , CL Pelkman , (2007) A reliable, valid questionnaire indicates that preference for dietary fat declines when following a reduced-fat diet. Appetite 49, 7483.

31D Greenberg , J McCaffery , JZ Potack , (1999) Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. Physiol Behav 66, 621626.

33MF Kuczmarski , RJ Kuczmarski & M Najjar (2001) Effects of age on validity of self-reported height, weight, and body mass index: findings from the Third National Health and Nutrition Examination Survey, 1988–1994. J Am Diet Assoc 101, 2834, quiz 35-36.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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