1. The effect of confinement stress on the metabolism of vitamin A was studied in ratsby following changes in tissue distribution of the vitamin for 29 d. In order to minimizepredicted errors which might result from fluctuation of vitamin A intake, the effect of the stress was investigated in rats fed on a vitamin A-free diet.
2. Daily stress for 6 h induced an enlargement of the adrenals with a concomitant involution of the thymus and spleen, values returning to normal within 11–15 d.
3. The stress caused an immediate decrease in the content of vitamin A in serum.
4. Feeding rats a vitamin A-free diet resulted in a significant increase in the vitamin Acontent of the kidney. Imposing stress on these rats inhibited markedly the increase in kidney vitamin A content.
5. The stress produced no appreciable change in levels of the vitamin in the liver andtestes.
6. There was a preferential accumulation of the vitamin in the adrenals of the stress-imposed rats even though they were fed on a vitamin A-free diet.
7. In conclusion, the results of the present study demonstrated that chronic immobilization stress produced marked tissue-dependent changes in their vitamin A content.
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