Skip to main content
×
Home
    • Aa
    • Aa

Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy

  • Tsunenobu Tamura (a1), Robert L. Goldenberg (a2), Kelley E. Johnston (a1) and Victoria R. Chapman (a2)
Abstract

We previously reported that pregnant women whose plasma Zn concentrations were below the 50th percentile tended to have high pre-pregnancy BMI (kg/m2) values. We therefore hypothesized that in pregnant women, plasma Zn concentrations are negatively correlated with BMI. We evaluated the association between BMI values and plasma Zn concentrations in 1474 women whose blood samples were obtained before 15 weeks of gestation. Their mean age was 22·7 years and mean gestational age at blood sampling was 10 weeks. The mean plasma Zn concentration and BMI were 11·6 μmol/l and 26·6 kg/m2 respectively. Because plasma Zn concentrations decrease as gestational age increases, plasma Zn concentrations were standardized by Z-scores. Z-score distributions were compared among the quartiles of BMI. The highest BMI group had the lowest plasma Zn concentrations, whereas the lowest BMI group had the highest; the differences were significant between the BMI groups (P<0·0001). The interpretation of plasma Zn concentrations to assess Zn nutriture in pregnancy may be complicated not only by the well-established factor of gestational age at blood sampling, but also by a previously unrecognized factor, maternal BMI.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor T. Tamura, fax +1205 934 7049, email tamurat@uab.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

RL Atkinson , WT Dahms , GA Bray , R Jacob & HH Sandstead (1978) Plasma zinc and copper in obesity and after intestinal bypass. Ann Int Med 89, 491493.

N Begin-Heick , M Dalpe-Scott , J Rowe & HMC Heick (1985) Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mice. Diabetes 34, 179184.

RK Chandra & KM Kutty (1980) Immunocompetence in obesity. Acta Paediatr Scand 69, 2530.

S Cnattingius , R Bergström , L Lipworth & MS Kramer (1998) Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med 338, 147152.

DL Donaldson , CC Smith & E Koh (1987) Effects of obesity and diabetes on tissue zinc and copper concentrations in the Zucker rat. Nutr Res 7, 393399.

EL Giroux (1975) Determination of zinc distribution between albumin and α2 -macroglobulin in human serum. Biochem Med 12, 258266.

RL Goldenberg , T Tamura , Y Neggers , RL Copper , KE Johnston , MB DuBard & JC Hauth (1995) The effect of zinc supplementation on pregnancy outcome. J Am Med Assoc 274, 463468.

Z Hashim , L Woodhouse & JC King (1996) Interindividual variation in circulating zinc concentrations among healthy adult men and women. Int J Food Sci Nutr 47, 383390.

A Marotta , N Todisco , A Di Toro , R Toraldo , G Ponte & L Perrone (1995) Zinc content of lymphocytes in obese children. Nutr Res 15, 14111415.

TC Pearson , DL Guthrie , J Simpson , S Chinn , G Barosi , A Ferrant , SM Lewis & Y Najean (1995) Interpretation of measured red cell mass and plasma volume in adults: expert panel on radionuclides of the International Council for Standardization in Haematology. Br J Haematol 89, 748756.

RE Serfass , MZ McHugh , BJ Struempler & PA Garcia (1983) Elemental balance in obese women fed a hypocaloric dietary regimen. Nutr Res 3, 157170.

T Tamura & RL Goldenberg (1996) Zinc nutriture and pregnancy outcome. Nutr Res 16, 139181.

T Tamura , KE Johnston , LE Freeberg , LL Perkins & RL Goldenberg (1994) Refrigeration of blood samples prior to separation is essential for the accurate determination of plasma or serum zinc concentrations. Biol Trace Elem Res 41, 165173.

R Tungtrongchitr , P Pongpaew , N Vudhivai , S Changbumrung , A Tungtrongchitr , B Phonrat , D Viroonudomphol , S Pooudong & FP Schelp (2003) Relationship between alpha-2-macroglobulin, anthropometric parameters and lipid profiles in Thai overweight and obese in Bangkok. Nutr Res 23, 11431152.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: