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Rich micronutrient fortification of locally produced infant food does not improve mental and motor development of Zambian infants: a randomised controlled trial

Abstract

It is uncertain whether multiple micronutrients benefit the mental and psychomotor development of young children in developing countries. We conducted a randomised double-blind controlled trial to evaluate the effect of a richly micronutrient-fortified v. a basal fortified porridge on mental and psychomotor development in Zambian infants. Infants (n 743) were randomised at age 6 months to receive either the richly fortified or the basal fortified infant food and were followed up until 18 months of age. All the infants were evaluated monthly for achievement of a series of developmental milestones. The Bayley scales of infant development II were administered to a subsample of 502 infants at 6, 12 and 18 months. Rich micronutrient fortification had no significant benefit on the following: (a) number of developmental milestones achieved (rate ratio at 12 months = 1·00; 95 % CI 0·96, 1·05; P = 0·81, adjusted for sex, socio-economic status and maternal education, with similar results at 15 and 18 months); (b) ages of walking unsupported (hazard ratio (HR) 1·04; 95 % CI 0·88, 1·24; P = 0·63, adjusted for the above covariates) and of speaking three or four clear words (HR 1·01; 95 % CI 0·84, 1·20; P = 0·94, adjusted for the above covariates); (c) mental development index (MDI) and psychomotor development index (PDI) of the Bayley scales (scores difference adjusted for baseline scores, age at the assessment, sex, socio-economic status, maternal education, language, age and HIV status: MDI 0·3 (95 % CI − 0·5, 1·1), P = 0·43; PDI − 0·1 (95 % CI − 0·9, 0·7), P = 0·78). In conclusion, the results do not support the hypothesis that rich micronutrient fortification improves Zambian infants' mental and motor development.

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Corresponding author
*Corresponding author: Dr Daniela Manno, fax +44 20 7958 811, email daniela.manno@lshtm.ac.uk
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3LH Allen , JM Peerson & DK Olney (2009) Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. J Nutr 139, 10221030.

4A Eilander , T Gera , HS Sachdev , (2009) Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials. Am J Clin Nutr 91, 115130.

9J Katz , SK Khatry , SC LeClerq , (2010) Daily supplementation with iron plus folic acid, zinc, and their combination is not associated with younger age at first walking unassisted in malnourished preschool children from a deficient population in rural Nepal. J Nutr 140, 13171321.

11E Pollitt , C Saco-Pollitt , A Jahari , (2000) Effects of an energy and micronutrient supplement on growth and development in undernourished children in Indonesia: methods. Eur J Clin Nutr 54, S16S20.

17VO Owino , MM Sinkala , B Amadi , (2007) Acceptability, storage stability and costing of α-amylase-treated maize–beans–groundnuts–bambaranuts complementary blend. J Sci Food Agric 87, 10211029.

19KG Dewey & K Brown (2003) Update on technical issues concerning complementary feeding of young children in developing countries and implications for intervention programs. Special issue based on a World Health Organization expert consultation on complementary feeding. Food Nutr Bull 24, 528.

24P Armitage , G Berry & JNS Matthews (2002) Statistical Methods in Medical Research, 4th ed.Oxford: Blackwell Science Ltd.

31SM Grantham-McGregor & CC Ani (1999) The role of micronutrients in psychomotor and cognitive development. Br Med Bull 55, 511527.

37MJ Gladstone , GA Lancaster , E Umar , (2010) The Malawi Developmental Assessment Tool (MDAT): the creation, validation, and reliability of a tool to assess child development in rural African settings. Plos Med 7, e1000273.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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Supplementary Materials

Manno Supplementary Figure 1
Manno Supplementary Figure 1

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67 KB
PDF
Supplementary Materials

Manno Supplementary Table 1
Supplementary Table 1. Description of the CIGNIS study population at recruitment

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86 KB