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Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion

  • Jacqueline N. Mathews (a1), Peter R. Flatt (a1) and Yasser H. Abdel-Wahab (a1)
Abstract

Diabetes mellitus is a complex metabolic disease characterised by glucose overproduction and under-utilisation. As the incidence of diabetes expands rapidly across the globe there is an urgent need to expand the range of effective treatments. Higher plants such as Asparagus adscendens provide therapeutic opportunities and a rich source of potential antidiabetic agents. In the present study an aqueous extract of Asparagus adscendens was shown to induce a significant non-toxic 19–248% increase in glucose-dependent insulinotropic actions (P<0·001) in the clonal pancreatic β cell line, BRIN-BD11. In addition, the extract produced an 81% (P<0·0001) increase in glucose uptake in 3T3-L1 adipocytes. Asparagus adscendens also produced a 21% (P<0·001) decrease in starch digestion in vitro. The present study has revealed the presence of insulinotropic, insulin-enhancing activity and inhibitory effects on starch digestion in Asparagus adscendens. The former actions are dependent on the active principle(s) in the plant being absorbed intact. Future work assessing its use as a dietary adjunct or as a source of active components may provide new opportunities for the treatment of diabetes

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Corresponding author
*Corresponding author: fax +44 (0)28 7032 4956, email y.abdel-wahab@ulster.ac.uk
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AF Amos , DJ McCarty & P Zimmet 1997 The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 14, S1S85.

JA Astin 1998 Why patients use alternative medicine. Results of a national study. JAMA 279, 15481553.

CJ Bailey & C Day 1989 Traditional treatments for diabetes. Diabetes Care 12, 553564.

CJ Clark 1998 The burden of chronic hyperglycaemia. Diabetes Care, C32C34.

RA De Fronzo , RC Banadonna & E Ferrannini 1992 Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15, 318368.

CJ Dunn & DH Peters 1995 Metformin: a review of its pharmacological properties and therapeutic use in NIDDM. Drugs 49, 721749.

PR Flatt & CJ Bailey 1981 Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20, 573577.

J Kawabata , Mizuhatak , E Sato , T Nishioka , Y Aoyana & T Kasai 2003 6-Hydroxyflavonoids as alpha-glucosidase inhibitors from majoram Origanum majorana leaves. Biosci Biotechnol Biochem 67, 445447.

H Kurihara , H Fukami , A Kusumoto , Y Toyoda , H Shibata , Y Matsui , S Asami & T Tanaka 2003 Hypoglycaemic action of Cyclocarya paliurus (Batal) Iljinskaja in normal and diabetic mice. Biosci Biotechnol Biochem 67, 877880.

A Laws 2001 A new era in type 2 diabetes mellitus treatment?. Am J Med 111, 7172.

S Lilloja , DM Mott , M Spraul , R Ferraro , JE Foley & E Ravussin Insulin resistance and insulin secretory dysfunction as precursor of non-insulin dependent diabetes mellitus. N Engl J Med 1993 329, 19881992.

NH McClenaghan , CR Barnett , E Ah-Sing , YHA Abdel-Wahab , FPM O'Harte , TW Yoon , SK Swanston-Flatt & PR Flatt 1996 Characterisation of a novel glucose responsive insulin secreting cell line, BRIN BD11, produced by electrofusion. Diabetes 45, 11321140.

AH MacLennan , DH Wilson & AW Taylor 1996 Prevalence and cost of alternative medicine in Australia. Lancet 347, 569573.

JC Miguel , YHA Abdel-Wahab , PC Mathias & PR Flatt 2003 Time-correlation between membrane depolarisation and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR. Cell Calcium 36, 4350.

BL Rhinehart , KM Robinson , AJ Payne , ME Wheatley JL Fisher , PS Liu & W Cheung 1987 Castanospermine blocks the hyperglycaemic response to carbohydrates in vivo: a result of intestinal disaccharidase inhibition. Life Sci 41, 23252331.

IM Shinwari & AM Khan 2000 Folk use of medicinal herbs of Margalla Hills National Park, Islamabad. J Ethnopharmacol 69, 4556.

UKPDS Perspectives in diabetes UKPDS Study 16 (1995) Overview of 6 years therapy of type II diabetes: a progressive disease. Diabetes 44, 12491258.

PB Weragoda 1980 Some questions about the future of traditional medicine in developing countries. J Ethnopharmacol 2, 193194.

Y Yoshikuni , 1998 Inhibition of intestinal a-glucosidase activity in postprandial hyperglycaemia by moraline and its n-alkyl derivatives. Agric Biol Chem 52, 121128.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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