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Specific probiotics in reducing the risk of acute infections in infancy – a randomised, double-blind, placebo-controlled study

  • Samuli Rautava (a1), Seppo Salminen (a2) and Erika Isolauri (a1)
Abstract

A randomised, double-blind, placebo-controlled study was conducted to determine whether probiotics might be effective in reducing the risk of infections in infancy. Infants requiring formula before the age of 2 months were recruited from community well-baby clinics. Infant formula supplemented with the probiotics Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb-12 or placebo was administered daily until the age of 12 months. Incidence of early infections (before the age of 7 months) and incidence of recurrent (three or more) infections during the first year of life were recorded as the main outcome measures of the study. During the first 7 months of life, seven out of thirty-two (22 %) infants receiving probiotics and twenty out of forty (50 %) infants receiving placebo experienced acute otitis media (risk ratio (RR) 0·44 (95 % CI 0·21, 0·90); P = 0·014) and antibiotics were prescribed for ten out of thirty-two (31 %) infants receiving probiotics and twenty-four out of forty (60 %) infants receiving placebo (RR 0·52 (95 % CI 0·29, 0·92); P = 0·015). During the first year of life, nine out of thirty-two (28 %) infants receiving probiotics and twenty-two out of forty (55 %) infants receiving placebo encountered recurrent respiratory infections (RR 0·51 (95 % CI 0·27, 0·95); P = 0·022). These data suggest that probiotics may offer a safe means of reducing the risk of early acute otitis media and antibiotic use and the risk of recurrent respiratory infections during the first year of life. Further clinical trials are warranted.

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Corresponding author
*Corresponding author: Dr Samuli Rautava, fax +358 2 3131460, email samrau@utu.fi
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2S Vesa , M Kleemola , S Blomqvist , (2001) Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age. Pediatr Infect Dis J 20, 574581.

4PG Holt & CA Jones (2000) The development of the immune system during pregnancy and early life. Allergy 55, 688697.

5E Isolauri , S Rautava , M Kalliomäki , (2002) Role of probiotics in food hypersensitivity. Curr Opin Allergy Clin Immunol 2, 263271.

7R Martin , S Langa , C Reviriego , (2003) Human milk is a source of lactic acid bacteria for the infant. J Pediatr 143, 754758.

10AC Ouwehand , E Isoauri , PV Kirjavainen , (2000) The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus. Lett Appl Microbiol 30, 1013.

12J Nokso-Koivisto , A Pitkäranta , S Blomqvist , (2002) Viral etiology of frequently recurring respiratory tract infections in children. Clin Inf Dis 35, 540546.

16H Szajewska , M Kotowska , JZ Mrukowicz , (2001) Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 138, 361365.

17JP Chouraqui , LD Van Egroo & MC Fichot (2004) Acidified milk formula supplemented with Bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr 38, 288292.

19K Hatakka , E Savilahti , A Ponka , (2001) Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322, 13271331.

22E Isolauri , H Majamaa , T Arvola , (1993) Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats. Gastroenterology 105, 16431650.

25Y Fukushima , Y Kawata , H Hara , (1998) Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 42, 3944.

26S Rautava , H Arvilommi & E Isoaluri (2006) Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Pediatr Res 60, 221224.

27M Kaila , E Isolauri , E Soppi , (1992) Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res 32, 141144.

28T Kilpi , E Herva , T Kaijalainen , (2001) Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infect Dis J 20, 654662.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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