Skip to main content
×
Home
    • Aa
    • Aa

UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health

  • John C. Stanley (a1) (a2), Rachel L. Elsom (a3), Philip C. Calder (a4), Bruce A. Griffin (a5), William S. Harris (a6), Susan A. Jebb (a7), Julie A. Lovegrove (a8), Carmel S. Moore (a7), Rudolph A. Riemersma (a9) and Tom A. B. Sanders (a10)...
Abstract

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 11 September 2006 to review the results of three FSA-funded studies and other recent research on effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health. The objective of this workshop was to reach a clear conclusion on whether or not it was worth funding any further research in this area. On the basis of this review of the experimental evidence and on theoretical grounds, it was concluded that the n-6:n-3 fatty acid ratio is not a useful concept and that it distracts attention away from increasing absolute intakes of long-chain n-3 fatty acids which have been shown to have beneficial effects on cardiovascular health. Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr J. C. Stanley, fax+44 1865 279911, email john.stanley@trinity.oxford.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1WS Harris (2006) The omega-6/omega-3 fatty acid ratio and cardiovascular disease risk: uses and abuses. Curr Atheroscler Rep 8, 453459.

4D Mozaffarian , A Ascherio , FB Hu , MJ Stampfer , WC Willett , DS Siscovick & EB Rimm (2005) Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 111, 157164.

5A Ascherio , EB Rimm , EL Giovannucci , D Spiegelman , M Stampfer & WC Willett (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313, 8490.

6FB Hu , MJ Stampfer , JE Manson , E Rimm , GA Colditz , BA Rosner , CH Hennekens & WC Willett (1997) Dietary fat and risk of coronary heart disease in women. N Eng J Med 337, 14911499.

7RB Shekelle , AM Shryock , O Paul , M Lepper , J Stamler , S Liu & WJ Raynor Jr (1981) Diet, serum cholesterol and death from coronary heart disease. N Eng J Med 304, 6570.

9P Leren (1970) The Oslo diet-heart study. Eleven-year report. Circulation 42, 935942.

10O Turpeinen , MJ Karvonen , M Pekkarinen , M Miettinen , R Elosuo & E Paavilainen (1979) Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study. Int J Epidemiol 8, 99118.

13TA Lennie , ML Chung , DL Habash & DK Moser (2005) Dietary fat intake and proinflammatory cytokine levels in patients with heart failure. J Cardiac Failure 11, 613618.

14T Pischon , SE Hankinson , GS Hotamisligil , N Rifai , WC Willett & EB Rimm (2003) Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 108, 155160.

15L Ferrucci , A Cherubini , S Bandinelli , B Bartali , A Corsi , F Lauretani , A Martin , C Andres-Lacueva , U Senin & JM Guralnik (2006) Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab 91, 439446.

16WS Harris , B Assaad & WC Poston (2006) Tissue omega-6/omega-3 fatty acid ratio and risk for coronary heart disease. Am J Cardiol 98, 19i26i.

20PC Calder (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 107, 111.

21PM Kris-Etherton , WS Harris & LJ Appel American Heart Association. Nutrition Committee (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.

25DS Kelley , GJ Nelson , JE Love , LB Branch , PC Taylor , PC Schmidt , BE Mackey & JM Iacono (1993) Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533537.

28WE Lands (2003) Diet could prevent many diseases. Lipids 38, 317321.

29WS Harris & C von Schacky (2004) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39, 212220.

33T Tillin , N Forouhi , DG Johnston , PM McKeigue , N Chaturvedi & IF Godsland (2005) Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population based cross-sectional study. Diabetologia 48, 649656.

35AM Minihane , LM Brady , SS Lovegrove , SV Lesauvage , CM Williams & JA Lovegrove (2005) Lack of effect of dietary n-6:n-3 PUFA ratio on plasma lipid and markers of insulin response in Indian Asians. Eur J Nutr 44, 2632.

39WE Lands , B Libelt , A Morris , NC Kramer , TE Prewitt , P Bowen , D Schmeisser , MH Davidson & JH Burns (1992) Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochim Biophys Acta 1180, 147162.

41CS Moore , SP Bryant , GD Mishra , JD Krebs , LM Browning , GJ Miller & SA Jebb (2006) Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. Nutrition 22, 10121024.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score