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Dried plums (prunes) reduce atherosclerosis lesion area in apolipoprotein E-deficient mice

  • Cynthia M. Gallaher (a1) and Daniel D. Gallaher (a1)
  • DOI:
  • Published online: 02 September 2008

Dried plums are a fruit high in pectin with substantial antioxidant activity. Previous studies in rats and man indicate that dried plums or plum fibre lower liver and plasma cholesterol, respectively. The apoE-deficient mouse, which develops atherosclerotic lesions rapidly when fed cholesterol, was used to determine the ability of dried plums to reduce atherosclerosis. Diets containing 0·15 % cholesterol and either 0 (B+C), 4·75 % (Lo DP) or 9·5 % (Hi DP) dried plum powder were fed for 5 months. An additional group fed the basal diet without cholesterol (B − C) was included as a negative control. Arterial trees were dissected, stained to visualize lesions, and lesion area was quantitated by imaging software. Urinary thiobarbituric acid-reactive substances (TBARS) excretion and serum amyloid P-component (SAP) were measured as indicators of oxidative stress and inflammation, respectively. Final serum cholesterol was significantly increased and serum TAG decreased in the B+C group and dried plum groups relative to the B − C group. Percentage arterial tree atherosclerotic lesion area was significantly lower in the B − C and Lo DP groups compared to the B+C group (P < 0·05), with a trend for a difference between the B+C and Hi DP groups (P = 0·075). SAP concentration was significantly lower in the B − C and Lo DP groups with the Hi DP group trending lower than the B+C group. Urinary TBARS excretion did not differ among the groups. These results suggest that consuming dried plums may help slow the development of atherosclerosis.

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*Corresponding author: Dr Daniel D. Gallaher, fax +1 612 625 5272, email
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2AR Ness & JW Powles (1997) Fruit and vegetables, and cardiovascular disease: a review. Int J Epidemiol 26, 113.

4National Cholesterol Education Program Expert Panel (1993) Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 269, 30153023.

9U Singh & I Jialal (2006) Oxidative stress and atherosclerosis. Pathophysiology 13, 129142.

13P Libby (2002) Inflammation in atherosclerosis. Nature 420, 868874.

14AM Wilson , MC Ryan & AJ Boyle (2006) The novel role of C-reactive protein in cardiovascular disease: risk marker or pathogen. Int J Cardiol 106, 291297.

20HE Miller , F Rigelhof , L Marquart , A Prakash & M Kanter (2000) Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr 19, 312S319S.

21JL Donovan , AS Meyer & AL Waterhouse (1998) Phenolic composition and antioxidant activity of prunes and prune juice (Prunus domestica). J Agric Food Chem 46, 12471252.

22N Nakatani , S Kayano , H Kikuzaki , K Sumino , K Katagiri & T Mitani (2000) Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J Agric Food Chem 48, 55125516.

23SH Zhang , RL Reddick , JA Piedrahita & N Maeda (1992) Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468471.

24AS Plump & JL Breslow (1995) Apolipoprotein E and the apolipoprotein E-deficient mouse. Annu Rev Nutr 15, 495518.

25M Mayr , YL Chung , U Mayr , (2005) Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol 25, 21352142.

27DO Kim , OK Chun , YJ Kim , HY Moon & CY Lee (2003) Quantification of polyphenolics and their antioxidant capacity in fresh plums. J Agric Food Chem 51, 65096515.

28GR Takeoka & LT Dao (2003) Antioxidant constituents of almond [Prunus dulcis (Mill.) D.A. Webb] hulls. J Agric Food Chem 51, 496501.

29G Cao , HM Alessio & RG Cutler (1993) Oxygen-radical absorbance capacity assay for antioxidants. Free Radic Biol Med 14, 303311.

31HS Lee , DW Shoeman & AS Csallany (1992) Urinary response to in vivo lipid peroxidation induced by vitamin E deficiency. Lipids 27, 124128.

35JF Bentzon , E Skovenborg , C Hansen , J Moller , NS de Gaulejac , J Proch & E Falk (2001) Red wine does not reduce mature atherosclerosis in apolipoprotein E-deficient mice. Circulation 103, 16811687.

38L Amigo , V Quinones , P Mardones , S Zanlungo , JF Miquel , F Nervi & A Rigotti (2000) Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 118, 772779.

41L Calleja , MA Paris , A Paul , (1999) Low-cholesterol and high-fat diets reduce atherosclerotic lesion development in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 19, 23682375.

42MH Moghadasian , BM McManus , DV Godin , B Rodrigues & JJ Frohlich (1999) Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action. Circulation 99, 17331739.

43J Danesh , JG Wheeler , GM Hirschfield , S Eda , G Eiriksdottir , A Rumley , GD Lowe , MB Pepys & V Gudnason (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350, 13871397.

44MB Pepys , M Baltz , K Gomer , AJ Davies & M Doenhoff (1979) Serum amyloid P-component is an acute-phase reactant in the mouse. Nature 278, 259261.

45PK Witting , K Pettersson , J Letters & R Stocker (2000) Site-specific antiatherogenic effect of probucol in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20, E26E33.

47A Piga , A Del Caro & G Corda (2003) From plums to prunes: influence of drying parameters on polyphenols and antioxidant activity. J Agric Food Chem 51, 36753681.

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