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The effect of a 48 h fast on the physiological responses to food ingestion in normal-weight women

Published online by Cambridge University Press:  09 March 2007

I. W. Gallen
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
I. A. Macdonald
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
P. I. Mansell
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
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Abstract

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The thermogenic, cardiovascular and metabolic responses to a 30 kJ/kg body-weight test meal were studied in eight normal-weight, healthy female subjects after a 6 or 48 h fast. There was no significant change in metabolic rate following the 48 h fast, but plasma glucose, insulin, noradrenaline and respiratory exchange ratio were all reduced, and plasma β-hydroxybutyrate was increased. Forearm blood flow was increased, with reduction in diastolic blood pressure. After the 48 h fast, there was a reduction in the metabolic rate response 40–90 min after food (control+0·54 (se 0·05), 48 h fast + 0·27 (se 0·12) kJ/min, I < 0·01), and in forearm blood flow and diastolic blood pressure responses, but increases in heart rate, blood glucose and plasma insulin responses to the ingestion of the test meal. There was no significant relationship between plasma catecholamine concentration and food ingestion or metabolic rate. Fasting induced considerable adaptation in these subjects and altered some of the physiological responses to food ingestion.

Type
Human Metabolic Responses to food
Copyright
Copyright © The Nutrition Society 1990

References

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