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Effect of adiposity on vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older Irish adults


There is increasing epidemiological evidence linking sub-optimal vitamin D status with overweight and obesity. Although increasing BMI and adiposity have also been negatively associated with the change in vitamin D status following supplementation, results have been equivocal. The aim of this randomised, placebo-controlled study was to investigate the associations between anthropometric measures of adiposity and the wintertime serum 25-hydroxycholecalciferol (25(OH)D) response to 15 μg cholecalciferol per d in healthy young and older Irish adults. A total of 110 young adults (20–40 years) and 102 older adults ( ≥ 64 years) completed the 22-week intervention with >85 % compliance. The change in 25(OH)D from baseline was calculated. Anthropometric measures of adiposity taken at baseline included height, weight and waist circumference (WC), along with skinfold thickness measurements to estimate fat mass (FM). FM was subsequently expressed as FM (kg), FM (%), FM index (FMI (FM kg/height m2)) and as a percentage ratio to fat-free mass (FFM). In older adults, vitamin D status was inversely associated with BMI (kg/m2), WC (cm), FM (kg and %), FMI (kg/m2) and FM:FFM (%) at baseline (r − 0·33, − 0·36, − 0·33, − 0·30, − 0·33 and − 0·27, respectively, all P values < 0·01). BMI in older adults was also negatively associated with the change in 25(OH)D following supplementation (β − 1·27, CI − 2·37, − 0·16, P = 0·026); however, no such associations were apparent in younger adults. Results suggest that adiposity may need to be taken into account when determining an adequate wintertime dietary vitamin D intake for healthy older adults residing at higher latitudes.

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1T Suda , Y Ueno , K Fujii , (2003) Vitamin D and bone. J Cell Biochem 88, 259266.

2MF Holick (2007) Vitamin D deficiency. N Engl J Med 357, 266281.

3GA Lumb , EB Mawer & SW Stanbury (1971) The apparent vitamin D resistance of chronic renal failure: a study of the physiology of vitamin D in man. Am J Med 50, 421441.

5NH Bell , S Epstein , A Greene , (1985) Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 76, 370373.

6Y Liel , E Ulmer , J Shary , (1988) Low circulating vitamin D in obesity. Calcif Tissue Int 43, 199201.

8S Nesby-O'Dell , KS Scanlon , ME Cogswell , (2002) Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 76, 187192.

9E Hypponen & C Power (2006) Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care 29, 22442246.

10S Arunabh , S Pollack , J Yeh , (2003) Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 88, 157161.

12B Ernst , M Thurnheer , SM Schmid , (2009) Seasonal variation in the deficiency of 25-hydroxyvitamin D(3) in mildly to extremely obese subjects. Obes Surg 19, 180183.

13AC Looker (2007) Do body fat and exercise modulate vitamin D status? Nutr Rev 65, S124S126.

14NH Bell , S Shaw & RT Turner (1984) Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J Clin Invest 74, 15401544.

15SJ Parikh , M Edelman , GI Uwaifo , (2004) The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89, 11961199.

16S Konradsen , H Ag , F Lindberg , (2008) Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 8791.

18J Wortsman , LY Matsuoka , TC Chen , (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72, 690693.

19MJ Barger-Lux , RP Heaney , S Dowell , (1998) Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int 8, 222230.

20M Blum , GE Dallal & B Dawson-Hughes (2008) Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults. J Am Coll Nutr 27, 274279.

21P Lee , JR Greenfield , MJ Seibel , (2009) Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index. Am J Med 122, 10561060.

22MH Canto-Costa , I Kunii & OM Hauache (2006) Body fat and cholecalciferol supplementation in elderly homebound individuals. Braz J Med Biol Res 39, 9198.

23ML Nelson , JM Blum , BW Hollis , (2009) Supplements of 20 microg/d cholecalciferol optimized serum 25-hydroxyvitamin D concentrations in 80 % of premenopausal women in winter. J Nutr 139, 540546.

24T Hill , A Collins , M O'Brien , (2005) Vitamin D intake and status in Irish postmenopausal women. Eur J Clin Nutr 59, 404410.

26Ministry of Agriculture, Fisheries and Food (MAFF) (1997) Food Portion Sizes. London: The Stationary Office.

28WE Siri (1956) The gross composition of the body. In Advances in Biological and Medical Physics, pp. 239280 [CA Tobias and JH Lawrence , editors]. New York: Academic Press.

30KD Cashman , TR Hill , AJ Lucey , (2008) Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr 88, 15351542.

31KD Cashman , JM Wallace , G Horigan , (2009) Estimation of the dietary requirement for vitamin D in free-living adults> = 64 y of age. Am J Clin Nutr 89, 13661374.

33TS Han , EM van Leer , JC Seidell , (1995) Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample. BMJ 311, 14011405.

34MB Snijder , RM van Dam , M Visser , (2005) Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90, 41194123.

35G Moschonis , S Tanagra , K Koutsikas , (2009) Association between serum 25-hydroxyvitamin D levels and body composition in postmenopausal women: the postmenopausal Health Study. Menopause 16, 701707.

36Z Lagunova , AC Porojnicu , F Lindberg , (2009) The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res 29, 37133720.

37SJ Winters , R Chennubhatla , C Wang , (2009) Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women. Metab Clin Exp 58, 438442.

38J MacLaughlin & MF Holick (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76, 15361538.

40V Hirani & P Primatesta (2005) Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey. Age Ageing 34, 485491.

41KL Rennie , JCK Wells , TA McCaffrey , (2006) The effect of physical activity on body fatness in children and adolescents. Proc Nutr Soc 65, 393402.

42TJ Cole , MS Fewtrell & A Prentice (2008) The fallacy of using percentage body fat as a measure of adiposity. Am J Clin Nutr 87, 1959.

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