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    Klevay, Leslie M. 2016. IHD from copper deficiency: a unified theory. Nutrition Research Reviews, p. 1.


    2015. Scientific Opinion on Dietary Reference Values for copper. EFSA Journal, Vol. 13, Issue. 10, p. 4253.


    Babić, Željka Tariba, Blanka Kovačić, Jelena Pizent, Alica Varnai, Veda M. and Macan, Jelena 2013. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception, Vol. 87, Issue. 6, p. 790.


    Mark, Alicja Budek Kápolna, Emese Laursen, Kristian H. Halekoh, Ulrich Rasmussen, Søren K. Husted, Søren Larsen, Erik H. and Bügel, Susanne 2013. Consumption of organic diets does not affect intake and absorption of zinc and copper in men – evidence from two cross-over trials. Food Funct., Vol. 4, Issue. 3, p. 409.


    Klevay, Leslie M. 2012. Searching for people low in copper. Metabolism, Vol. 61, Issue. 9, p. 1201.


    Klevay, Leslie M. 2011. Is the Western diet adequate in copper?. Journal of Trace Elements in Medicine and Biology, Vol. 25, Issue. 4, p. 204.


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    Nieboer, Evert Thomassen, Yngvar Romanova, Natalya Nikonov, Alexander Øyvind Odland, Jon and Chaschin, Valery 2007. Multi-component assessment of worker exposures in a copper refinery : Part 2. Biological exposure indices for copper, nickel and cobalt. J. Environ. Monit., Vol. 9, Issue. 7, p. 695.


    Ferrari, Carlos K B 2005. Minerals. Evidence-Based Integrative Medicine, Vol. 2, Issue. 3, p. 123.


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Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women

  • Susanne Bügel (a1), Angela Harper (a1), Edmond Rock (a2), Jacqueline M. O'Connor (a3), Maxine P. Bonham (a3) and J. J. Strain (a3)
  • DOI: http://dx.doi.org/10.1079/BJN20051470
  • Published online: 01 March 2007
Abstract

Western diets containing suboptimal Cu concentrations could be widespread. A link between marginal Cu deficiency and CVD has been suggested. The objective of the present study was to investigate the effect of Cu supplementation on both Cu status and CVD risk factors in healthy young women. Sixteen women with a mean age of 24 (sd 2) years participated in a randomised crossover study of three 4-week periods with 3-week washouts between periods. During each intervention period, subjects received 0, 3 or 6 mg elemental Cu/d as CuSO4 in addition to their habitual diet. Blood samples were taken to assess the effect of supplementation on putative markers of Cu status. The content of plasma lipids, lipoprotein (a), apo and certain haemostatic factors, as putative indices of CVD, was also analysed. Daily supplementation with 3 mg Cu significantly increased (P<0·05) serum Cu concentration and the activity of erythrocyte superoxide dismutase, although there was no further significant increase after an intake of 6 mg Cu/d. The concentration of the fibrinolytic factor plasminogen activator inhibitor type 1 was significantly reduced (P<0·05) by about 30% after supplementation with 6 mg Cu/d. No other marker of Cu status or CVD risk factor was affected by Cu supplementation. The results indicate that supplementation with 3 or 6 mg Cu/d may improve Cu status in these healthy young women. Increased Cu intake could reduce the risk of CVD and atherosclerosis in man by promoting improved fibrinolytic capacity.

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Corresponding author
*Corresponding author: Dr Susanne Bügel, fax +45 35 28 24 83, email shb@kvl.dk
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A Clauss (1957) Rapid physiological coagulation method for the determination of fibrinogen [German]. Acta Haematol 17, 237246.

DM Danks (1988) Copper deficiency in humans. Annu Rev Nutr 8, 235257.

AA Jones , RA DiSilvestro , M Coleman & TL Wagner (1997) Copper supplementation of adult men: effects on blood copper enzyme activities and indicators of cardiovascular disease risk. Metab Clin Exp 46, 13801383.

LM Klevay (1998) Lack of a recommended dietary allowance for copper may be hazardous to your health. J Am Coll Nutr 17, 322326.

DM Medeiros , A Milton , E Brunette & L Stacy (1991 b) Copper supplementation effects on indicators of copper status and serum-cholesterol in adult males. Biol Trace Elem Res. 30, 1935.

DB Milne , PE Johnson , LM Klevay & HH Sandstead (1990) Effect of copper intake on balance, absorption, and status indices of copper in men. Nutr Res 10, 975986.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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