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British Journal of Nutrition British Journal of Nutrition

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The effect of dietary 1,25-dihydroxycholecalciferol in preventing tibial dyschondroplasia in broilers fed on diets imbalanced in calcium and phosphorus

Published online by Cambridge University Press:  09 March 2007

J. Sarah Rennie ,
Colin C. Whitehead  and
Barry H. Thorp
J. Sarah Rennie
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
Colin C. Whitehead
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
Barry H. Thorp
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS
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Abstract

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Three experiments were carried out to investigate the effects of supplemental dietary 1·25-dihydroxycholecalciferol (1·25(OH)2cholecalciferol) and a low dietary Ca:P ratio on the occurrence of tibial dyschondroplasia (TD) in 3-week-old broilers. Histopathology was used to diagnose TD. In the first experiment, feeding a diet containing 7·5 g Ca and 7·6 g P/kg gave a higher incidence of TD than a control diet containing normal amounts of Ca and P (12 and 6 g/kg respectively). Increasing the dietary supplement of cholecalciferol in the imbalanced diet prevented rickets but did not decrease the incidence of TD. In the second experiment, supplementing the imbalanced diet with 10 μg 1·25(OH)2cholecalciferol/kg prevented TD completely but also gave a slight growth depression. In the third experiment the imbalanced diet was supplemented with 0, 2·5, 5 or 10 μg 1·25(OH)2 cholecalciferol/kg. The supplement of 2·5 μg/kg depressed and the higher supplements prevented the occurrence of TD, this time without a growth depression. Feeding the 10 μg/kg supplement for the first week only did not prevent TD. Plasma total Ca, inorganic P and alkaline phosphatase (EC 3·1·3·1) were unaffected by diet but 1·25(OH)2cholecalciferol was higher on the imbalanced than on the control diet. Supplementation of the imbalanced diet with 1·25(OH)2cholecalciferol did not increase plasma levels. It is concluded that 1·25(OH)2cholecalciferol is exerting a powerful biological effect in this model of TD, but the mechanism is unclear.

Keywords

Tibial dyschondroplasiaCholecalciferol1,25(0H)2cholecalciferolCalcium-phosphorus balanceBroilers
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 3 , May 1993 , pp. 809 - 816
Copyright
Copyright © The Nutrition Society 1993

References

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The effect of dietary 1,25-dihydroxycholecalciferol in preventing tibial dyschondroplasia in broilers fed on diets imbalanced in calcium and phosphorus
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